Hepatogenous Photosensitization in Cattle Fed a Grass Hay

Witte, Scott T.; Curry, Scott L.

doi:10.1177/104063879300500135

Cited by 9 publications

(5 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These findings along with high level of phylloerythrin confirmed the case of hepatogenous photosensitization. Likewise, such laboratory findings are comparable to those of Witte et al, (30) and Sean et al, (22). Compared to healthy lambs, the affected lambs high triglyceride levels in addition to hypercholesterolemia.…”

Section: Discussionsupporting

confidence: 79%

“…Such lesions were characteristics of hepatotoxicity casued by ingestion of Tribulus terrestris. These findings are charecteristic to hepatogenous photosensitization and comparable to those reported by Sean et al, (22), Wisløff et al, (29), and Witte et al, (30) Leukocytosis and increase in body temperature, common laboratory findings, are frequently occur in infections or during the inflammatory processes. Opasina (14) claimed that the body temperature in sheep showing the symptoms of photosentisation was in normal range (38.7±0.7 0 C).…”

Section: Discussionsupporting

confidence: 78%

“…Bilirubinuria along with icterus was reported in hepatogenous photosentization in sheep (22) and in cattle (30). In our study, we detected varying degrees of bilirubinuria in qualitative examination of urine samples, but hemoglobinuria and a conspicious case of icterus were not present in our cases.…”

Section: Discussionmentioning

confidence: 40%

See 2 more Smart Citations

Hepatogenous photosensitization in Akkaraman lambs: special emphasis to oxidative stress and thrombocytopenia

Öcal¹,

Haydardedeoğlu²,

Çınar³

et al. 2013

Ankara Üniversitesi Veteriner Fakültesi Dergisi

View full text Add to dashboard Cite

Summary:In this study, a total of 24 Akkaraman lambs with clinical signs that are reminiscent of photosensitization composed the experimental group (Group I). Additional 10 healthy lambs were included as controls (Group II). We were aimed to make definitive diagnosis of photosensitization, which can be confused with blue tongue, big head and sunburns and to establish etiology as primary or hepatogenous. In total blood analyses, the leukocyte count was higher, but thrombocyte count was lower (thrombocytopenia) in Group I compared to Group II. The lower MCV indicates presence of a case of microcytosis. Furthermore, affected lambs had significantly higher levels of phylloerythrin, γ-glutamyl transpeptidase, aspartate aminotransferase, alkaline phosphatase, cholesterol and serum urea nitrogen. Histopathological lesions included periaciner necrosis, periportal fibrosis and biliary duct hyperplasy. The grazing field, where the lambs had been grazing, was very rich in Tribulus terrestris, a hepatotoxic plant. Based on the increased levels of phylloerythrin, γ-glutamyl transpeptidase, aspartate aminotransferase and alkaline phosphatase as well as pathological findings in liver, the cases were diagnosed as hepatogenous photosensitization. In addition, presence of Tribulus terrestris in the grazing pasture strongly supported the diagnosis. Increased levels of serum malondialdehyde in affected lambs showed an ongoing oxidative stress. In addition, thrombocytopenia in such cases should be considered as a risk factor for disseminated intravascular coagulation (DIC). Thus in addition to a semptomatical treatment protocol, use of antioxidants, anticoagulants, and liver protective agents shoud be taken into consideration in hepatogenous photosensitization in lambs.Key words: Lamb, malondialdehyde, microcytosis, oxidative stress, photosensitization, Tribulus terrestris, thrombocytopenia, Akkaraman kuzularda hepatojen fotosensitizasyon: oksidatif stres ve trombostopeniye özel vurguÖzet: Bu çalışmada, klinik olarak fotosensitizasyona benzeyen semptomlar gösteren farklı cinsiyetten 24 (Grup I) ve 10 tane de sağlıklı (Grup II) Akkaraman kuzu çalışmanın hayvan materyalini oluşturdu. Kuzularda mavi dil, big head (koca kafa) ve güneş yanığı ile karışabilen fotosensitizasyonun kesin tanısının yapılması, etiyolojik olarak primer veya sekonder (hepatojen) tip olup olmadığının ortaya konması amaçlandı. Sağlıklı kuzulara göre hastaların lökosit sayısının yüksek, trombosit sayısının ise düşük (trombositopeni) olduğu saptandı (P<0.001). Ayrıca düşük MCV değeri mikrositozis olarak değerlendirildi. Biyokimyasal analizlerde hasta kuzuların filloeritrin, γ-glutamil transpeptidaz, aspartat aminotransferaz, alkalin fosfataz, kolesterol değerlerinin P<0.001 ve serum üre nitrogen değerinin ise P<0.01 düzeyinde yüksek olduğu belirlendi. Histopatolojik incelemede periasiner nekrozis, periportal fibrozis ve bilier kanal hiperplazisi ortaya kondu. Yapılan mera taramasında, kuzuların otlatıldığı tarlaların bitki örtüsünün demir dikeni (Tribulus terrestris...

show abstract

Section: Discussionsupporting

confidence: 79%

Section: Discussionsupporting

confidence: 78%

See 1 more Smart Citation

Hepatogenous photosensitization in Akkaraman lambs: special emphasis to oxidative stress and thrombocytopenia

Öcal¹,

Haydardedeoğlu²,

Çınar³

et al. 2013

Ankara Üniversitesi Veteriner Fakültesi Dergisi

View full text Add to dashboard Cite

show abstract

“…The diagnosis was confirmed through nine of ten fecal samples taken on 12 May, and via fecal samples from three necropsied steers at the University of Wisconsin Veterinary Diagnostics Laboratory. Necropsied steers died on 11 May (1) and 12 May (2). By 20 May, coccidiosis appeared to have passed and cattle were in recovery.…”

Section: Case Descriptionmentioning

confidence: 99%

“…Clinical signs have been seen within 24 h of induced cases [1]. On farm, photosensitivity clinical signs have been reported to be observed within 4 days [2] to several weeks [3] after a change in feed source. There are three types of photosensitization based on etiology: primary or Type 1, direct consumption of photodynamic agent; congenital or Type 2; and hepatogenous or secondary/Type 3 [4].…”

Section: Introductionmentioning

confidence: 98%

Hepatogenous Photosensitivity Outbreak after Coccidiosis in Grazing Holstein Steers

Nieman

Schaefer

Maroney

et al. 2020

Veterinary Sciences

View full text Add to dashboard Cite

Clinical signs of photosensitivity in cattle can occur sporadically and unpredictably. It is believed that cases of photosensitivity may be underreported, causing inaccurate and inflated reports of mortality. Additionally, because secondary photosensitization in grazing cattle occurs with liver damage or dysfunction, photosensitivity can have many potential or associated causes. This case links a previous occurrence of coccidiosis to an outbreak of photosensitivity in grazing Holstein steers. Grazing management staff first observed clinical signs of photosensitivity 17 days after an outbreak of coccidiosis and subsequent turnout to spring pastures. Clinical signs were observed in 25% of the population. The severity of photosensitivity was variable and ranged from blistered skin on the muzzle to sloughing of unpigmented epidermis and thinly haired regions. Severely affected cattle were removed from pasture, housed under shade, monitored for infection, and recovered without treatment. Mild cases remained on pasture and recovered without treatment. Photosensitivity did not reoccur in the cattle that remained on pasture or in mildly affected cattle returned to pasture. Photosensitivity did not appear to be associated with pasture weeds, a specific forage species, or variable or extreme weather conditions that could have resulted in mycotoxin production. The occurrence appears to have been a result of a previous and concurrent coccidiosis outbreak that caused secondary photosensitization through hepatic lipidosis caused by anorexia and dehydration associated with the severe coccidiosis. Although clinical signs appeared suddenly, cattle recovered quickly and without treatment.

show abstract

Plants

Plumlee¹

2004

Clinical Veterinary Toxicology

View full text Add to dashboard Cite

Hepatogenous Photosensitization in Cattle Fed a Grass Hay

Cited by 9 publications

References 8 publications

Hepatogenous photosensitization in Akkaraman lambs: special emphasis to oxidative stress and thrombocytopenia

Hepatogenous photosensitization in Akkaraman lambs: special emphasis to oxidative stress and thrombocytopenia

Hepatogenous Photosensitivity Outbreak after Coccidiosis in Grazing Holstein Steers

Plants

Contact Info

Product

Resources

About