HEPATOFLUO: A prospective monocentric study assessing the benefits of indocyanine green (ICG) fluorescence for hepatic surgery

Peyrat, Patrice; Blanc, Ellen; Guillermet, Stéphanie; Chen, Yao; Ferlay, Céline; Pérol, David; Basso, Valéria; Rivoire, Michel; Dupré, Aurélien

doi:10.1002/jso.25011

Cited by 26 publications

(16 citation statements)

References 17 publications

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“…Some clinical centers have reported the use of ICG molecular fluorescence imaging technology for the diagnosis and treatment of liver tumors [3][4][5][6]29]. However, whether it can improve the surgical treatment of liver tumors is still lack of domestic and foreign high-quality evidence.…”

Section: Discussionmentioning

confidence: 99%

“…It is not easy to distinguish the color difference between the left and right hemipatic by just blocking the flow of blood into the right hemipatial blood on the hepatic surface marker tangent line, even inject methylene blue into the right portal vein to stain the right hemihepatic, therefore it is difficult to improve the precision of hepatectomy. In recent years, with the rapid development of molecular imaging technology, indocyanine green (ICG), as a near-infrared fluorescent dye, has been intensively applied in the field of liver surgery [3][4][5][6]. By injecting ICG into the corresponding liver segment or the liver lobe, we are able to develop an ICG fluorescence imaging system (photodynamic eye) to guide precise hepatectomy.…”

Section: Introductionmentioning

confidence: 99%

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Precise right hemihepatectomy for the treatment of hepatocellular carcinoma guided by fusion ICG fluorescence imaging

Yao¹,

Zhang²,

Ma³

et al. 2020

J. Cancer

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To evaluate the clinical significance of fusion indocyanine green (ICG) fluorescence imaging in precise right hemihepatectomy for the treatment of hepatocellular carcinoma (HCC). 47 patients with HCC who underwent right hemihepatectomy were retrospectively analyzed. 18 of them guided by fusion ICG fluorescence imaging (FIGFI) while 29 patients underwent conventional right hepatectomy without guidance. Compared to the patients with conventional treatment, the intraoperative blood loss of the patients with guided surgery was significantly less, and no transfusion and hepatic occlusion were performed during the operation. Liver function recovery faster in guided group. The incidence of postoperative complications is also lower, and the recurrence rate in one year is significantly reduced. ICG fluorescence range of 18 patients in liver surface was consistent with the ischemic line, and their postoperative liver cross-sections were clearly demarcation. There were no significant differences in the mean operation time, blood loss, postoperative hospital stays, cases of blood transfusion, complication rate, or postoperative peak volume of ALT and TB between positive or negative staining groups. Pathology results of all patients demonstrated HCC and negative margins, and microvascular invasion occurred in 8 cases. The average follow-up time of 18 patients was 16.7 months, and recurrence was found in 5 cases after surgery. FIGFI could guide the anatomical right hepatectomy with real-time increased radical rate, accuracy and safety for the treatment of HCC, and therefore showed a promising prospect.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Precise right hemihepatectomy for the treatment of hepatocellular carcinoma guided by fusion ICG fluorescence imaging

Yao¹,

Zhang²,

Ma³

et al. 2020

J. Cancer

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“…The time between ICG injection and hepatectomy of 1 to 28 days has also been the topic of several publications (10,18,29,31,32,36,38,39), while interval not more than 3 days (35) and 2 weeks (20,28,34,40) were also proposed by other groups. The interval is related to liver function: poor liver function and cirrhosis (41) will take much longer to extract ICG from the blood to the bile, as well as complete cellular washout.…”

Section: Discussionmentioning

confidence: 99%

The use of indocyanine green imaging technique in patient with hepatocellular carcinoma

Huang¹,

Ou²,

Wong³

2018

Transl. Gastroenterol. Hepatol

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Near-infrared indocyanine green (ICG) fluorescence application in liver cancer surgery have been reported in the literature since 2008. To date, most reports emphasized not only to the safety, feasibility and reproducibility, but also the potential benefits of its clinical applications in term of demarcating segmentation for an anatomical resection, tumor identification to achieve tumor free resection margin, detection of small unidentifiable subcapsular nodules as well as extrahepatic metastatic lesions, and fluorescence cholangiography. The purpose of this review is to present the fundamental concept of the interpretation of fluorescence enhancement by different timing through intravascular ICG distribution to liver and biliary washout; to describe step-by-step technical aspects of its use in different purposes, and to expose the diagnostic and therapeutic perspectives of this innovative imaging technique in liver cancer surgery.

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“…In 11 articles, 18,59,67,70,77-83 the importance of using IOUS was highlighted and its evolution through the years was described, despite its application during MILS requiring further skills as compared to open surgery. In addition, the various intraoperative use of the indocyanine green (ICG) was assessed in 24 articles, 53,75,[80][81][82][84][85][86][87][88][89][90][91][92][93][94][95][96][97][98][99][100][101][102][103] the portal dye injection in eight articles, 18,70,79,83,94,98,104,105 and contrast-enhanced ultrasonography in three articles, 79,80,82 when performing ALR.…”

Section: Liver Surface or Intrahepatic Anatomic Structuresmentioning

confidence: 99%

Landmarks to identify segmental borders of the liver: A review prepared for PAM‐HBP expert consensus meeting 2021

Wakabayashi

Cacciaguerra

Ciria

et al. 2021

J Hepato Biliary Pancreat

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Background:In preparation for the upcoming consensus meeting in Tokyo in 2021, this systematic review aimed to analyze the current available evidence regarding surgical anatomy of the liver, focusing on useful landmarks, strategies and technical tools to perform precise anatomic liver resection (ALR). Methods: A systematic review was conducted on MEDLINE/PubMed for English articles and on Ichushi database for Japanese articles until September 2020. The quality assessment of the articles was performed in accordance with the Scottish Intercollegiate Guidelines Network (SIGN). Results: A total of 3169 manuscripts were obtained, 1993 in English and 1176 in Japanese literature. Subsequently, 63 English and 20 Japanese articles were selected and reviewed. The quality assessment of comparative series and case series was revealed to be usually low; only six articles were qualified as high quality. Forty-two articles focused on analyzing intersegmental/sectional planes and their relationship

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HEPATOFLUO: A prospective monocentric study assessing the benefits of indocyanine green (ICG) fluorescence for hepatic surgery

Abstract: This study confirmed that intraoperative fluorescence is a helpful and relevant tool for the liver surgeon (NCT 01738217).

Cited by 26 publications

References 17 publications

Precise right hemihepatectomy for the treatment of hepatocellular carcinoma guided by fusion ICG fluorescence imaging

Precise right hemihepatectomy for the treatment of hepatocellular carcinoma guided by fusion ICG fluorescence imaging

The use of indocyanine green imaging technique in patient with hepatocellular carcinoma

Landmarks to identify segmental borders of the liver: A review prepared for PAM‐HBP expert consensus meeting 2021

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