Hepatocytes undergo punctuated expansion dynamics from a periportal stem cell niche in normal human liver

Passman, Adam M.; Haughey, Magnus J; Carlotti, Emanuela; Williams, Michael J.; Cereser, Biancastella; Lin, Meng-Lay; Devkumar, Shruthi; Gabriel, Jonathon p; Gringeri, Enrico; Cillo, Umberto; Russo, Francesco Paolo; Hoare, Matthew; Chin–Aleong, Joanne; Jansen, Marnix; Wright, Nicholas A.; Kocher, Hemant M.; Huang, Weini; Alison, Malcolm R.; McDonald, Stuart

doi:10.1016/j.jhep.2023.03.044

Cited by 4 publications

(2 citation statements)

References 53 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…have demonstrated this approach by tracking spatially restricted clonal expansion among hepatocytes based on detecting mtDNA mutations. 189 These results indicate that mtDNA mutations may also have great potential for the study of premalignant states that precede blood malignancies, for example, by dissecting clonal hematopoiesis below the level of individual driver mutations, as shown by Miller et al in one selected case. 190 …”

Section: Tracking Cancer Cell Evolution Using Natural Genetic Barcodesmentioning

confidence: 70%

Single-cell genomics-based immune and disease monitoring in blood malignancies

Rathgeber,

Ludwig,

Penter

2024

Clinical Hematology International

View full text Add to dashboard Cite

Achieving long-term disease control using therapeutic immunomodulation is a long-standing concept with a strong tradition in blood malignancies. Besides allogeneic hematopoietic stem cell transplantation that continues to provide potentially curative treatment for otherwise challenging diagnoses, recent years have seen impressive progress in immunotherapies for leukemias and lymphomas with immune checkpoint blockade, bispecific monoclonal antibodies, and CAR T cell therapies. Despite their success, non-response, relapse, and immune toxicities remain frequent, thus prioritizing the elucidation of the underlying mechanisms and identifying predictive biomarkers. The increasing availability of single-cell genomic tools now provides a system’s immunology view to resolve the molecular and cellular mechanisms of immunotherapies at unprecedented resolution. Here, we review recent studies that leverage these technological advancements for tracking immune responses, the emergence of immune resistance, and toxicities. As single-cell immune monitoring tools evolve and become more accessible, we expect their wide adoption for routine clinical applications to catalyze more precise therapeutic steering of personal immune responses.

show abstract

Section: Tracking Cancer Cell Evolution Using Natural Genetic Barcodesmentioning

confidence: 70%

Single-cell genomics-based immune and disease monitoring in blood malignancies

Rathgeber,

Ludwig,

Penter

2024

Clinical Hematology International

View full text Add to dashboard Cite

show abstract

“…This intrinsic ability to express multipotent genes is possibly a conserved survival mechanism in rare populations of mature liver cells under chronic conditions. These cells could have originated from the same precursor or stem cells during embryonic development [170]. Although the link between DRs and the progression of liver diseases is indisputable, pathological DRs are strongly correlated with fibrosis progression and disease severity in many chronic liver diseases.…”

Section: Translational Significance Of Drsmentioning

confidence: 99%

Ductular Reactions in Liver Injury, Regeneration, and Disease Progression—An Overview

Mavila,

Siraganahalli Eshwaraiah,

Kennedy

2024

Cells

View full text Add to dashboard Cite

Ductular reaction (DR) is a complex cellular response that occurs in the liver during chronic injuries. DR mainly consists of hyper-proliferative or reactive cholangiocytes and, to a lesser extent, de-differentiated hepatocytes and liver progenitors presenting a close spatial interaction with periportal mesenchyme and immune cells. The underlying pathology of DRs leads to extensive tissue remodeling in chronic liver diseases. DR initiates as a tissue-regeneration mechanism in the liver; however, its close association with progressive fibrosis and inflammation in many chronic liver diseases makes it a more complicated pathological response than a simple regenerative process. An in-depth understanding of the cellular physiology of DRs and their contribution to tissue repair, inflammation, and progressive fibrosis can help scientists develop cell-type specific targeted therapies to manage liver fibrosis and chronic liver diseases effectively.

show abstract

An integrative experimental and computational twin modeling approach to understand clonal dynamics in the normal liver

Drasdo

Zhao

2023

Journal of Hepatology

View full text Add to dashboard Cite

Hepatocytes undergo punctuated expansion dynamics from a periportal stem cell niche in normal human liver

Cited by 4 publications

References 53 publications

Single-cell genomics-based immune and disease monitoring in blood malignancies

Single-cell genomics-based immune and disease monitoring in blood malignancies

Ductular Reactions in Liver Injury, Regeneration, and Disease Progression—An Overview

An integrative experimental and computational twin modeling approach to understand clonal dynamics in the normal liver

Contact Info

Product

Resources

About