Hepatocyte growth factor/scatter factor in development, inflammation and carcinogenesis: its expression and role in oral tissues

Hepatocyte growth factor in saliva is a potential marker of symptomatic periodontal disease

“…In 2002, Japanese authors found significant correlations between the salivary level of HGF and periodontal parameters such as PD and GI, and postulated that salivary HGF might be useful as a screening marker for early detection of periodontal disease (8). At the same time, some of the above ex vivo and clinical data (4)(5)(6)(7)(8) were confirmed by Daikuhara and coworkers (9,10). Notably, a recent study has shown that HGF overproduction by inflamed human gingival fibroblasts is mediated by protease-activated receptors (17), thus corroborating the HGF/periodontal disease relationship on a molecular basis.…”

“…Remarkably, HGF is also involved in the development of periodontal disease (3)(4)(5)(6)(7)(8)(9)(10). Recently, it was shown that HGF levels in unstimulated whole mixed saliva are directly correlated with probing depth and the percentage of sites positive for bleeding on probing in the general population (8).…”

Regulation of microRNA expression by hepatocyte growth factor in human head and neck squamous cell carcinoma

“…(4)(5)(6) It is also known to be a scatter factor (SF) (4) and involved in tumor-stromal interactions and EMT. (25,26) MET, a specific receptor tyrosine kinase for HGF ⁄ SF, is upregulated in various tumors including human HNSCC and its signal transduction induces progression and invasiveness of HNSCC in a paracrine or autocrine manner.…”

“…(2) One of these factors, hepatocyte growth factor (HGF), is a multifunctional growth factor that acts as mitogen, motogen and ⁄ or morphogen in a variety of cells including squamous epithelial cells. (4)(5)(6) MET, a specific receptor tyrosine kinase for HGF, is upregulated in various tumors including human HNSCC, and its signal transduction to the nucleus induces the expression of genes involving the progressive and invasive characteristics of HNSCC. (5)(6)(7) However, how HGF affects downstream functional gene expression has not yet been elucidated in detail.…”

Hepatocyte Growth Factor in Saliva of Patients with Renal Failure and Periodontal Disease

“…They include impact on bone metabolism, proliferation of epithelial cells, healing process, and local inflammatory condition. Experimental research carried out by the Yasushi Daikuhara group (Kagoshima University Dental School, Kagoshima, Japan) in the years 1993-2000 proved, for the first time, that gingival and dental pulp fibroblasts show the ability to HGF synthesis and secretion, [5][6][7][8] and this effect is particularly expressed during the exposure of fibroblasts in tissue culture to proinflammatory substances such as interleukin-1, tumor necrosis factor, and prostaglandin E 2 . The connection between HGF and periodontitis was described for the first time by Ohshima et al [9][10][11] (Nihon University School of Dentistry, Tokyo, Japan) in a series of articles published in the years 2000-2002. In clinical examination, they showed, for the first time, that HGF level in the fluid of gingival pockets in patients with PD is between 10 and 20 times higher than in subjects without PD.…”