Hepatocellular carcinoma with steatohepatitic features: a clinicopathological study of <scp>J</scp>apanese patients

Shibahara, Junji; Ando, Sumiyo; Sakamoto, Yoshihiro; Fukayama, Masashi

doi:10.1111/his.12343

Cited by 84 publications

(137 citation statements)

References 17 publications

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“…However, we only identified DM history to be significantly associated with SH‐HCC in the three groups of patients with HCC, while hypertension, high serum CHO, and TG levels were not. Thus, our data differ slightly from the two published reports 37, 38. Because SH‐HCC has not been found to be associated with prognosis, its clinical significance will need further study.…”

Section: Discussioncontrasting

confidence: 99%

“…SH‐HCC has also been reported to be associated with metabolic syndrome,37, 38 which we confirmed in this study. However, we only identified DM history to be significantly associated with SH‐HCC in the three groups of patients with HCC, while hypertension, high serum CHO, and TG levels were not.…”

Section: Discussionsupporting

confidence: 88%

“…The criteria for the diagnosis of steatohepatitic HCC (SH‐HCC) included: 1) steatosis (>5% tumor cells with macrovesicular fatty change); 2) ballooning or Mallory‐Denk body formation is identified; 3) presence of interstitial fibrosis, and 4) presence of inflammatory infiltrate in the tumor 37, 38…”

Section: Methodsmentioning

confidence: 99%

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Metabolic risk factors are associated with non‐hepatitis B non‐hepatitis C hepatocellular carcinoma in Taiwan, an endemic area of chronic hepatitis B

Huang

Chang

Hong

et al. 2018

Hepatology Communications

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Metabolic risk factors, such as obesity, fatty liver, high lipidemia, and diabetes mellitus are associated with increased risk for nonviral hepatocellular carcinoma (HCC); however, few nonviral HCC studies have stratified patients according to underlying etiologies. From 2005 to 2011, 3,843 patients with HCC were recruited into the Taiwan Liver Cancer Network. Of these patients, 411 (10.69%) who were negative for hepatitis B virus (HBV), surface antigen, HBV DNA, and anti‐hepatitis C virus (HCV) antibody were classified as non‐HBV non‐HCV (NBNC)‐HCC. Detailed clinical analyses of these patients were compared with age‐ and sex‐matched patients with HBV‐HCC or HCV‐HCC for the associated metabolic risk factors. For this comparison, 420 patients with HBV‐HCC and 420 patients with HCV‐HCC were selected from the 3,843 patients with HCC. Multivariate analyses showed fatty liver (by echography), high triglyceride levels (>160 mg/dL), and diabetes mellitus history to be significantly associated only with NBNC‐HCC and not with the matched patients with HBV‐ or HCV‐HCC. When the patients with HCC were further divided into four groups based on history of alcoholism and cirrhotic status, the group without alcoholism and without cirrhosis exhibited the strongest association with the metabolic risk factors. Based on trend analyses, patients with NBNC‐HCC with or without alcoholism were significantly different from the matched patients with HBV‐ or HCV‐HCC, except for patients with alcoholism and cirrhosis, in having more than two of the above three risk factors. Conclusion: Metabolic risk factors are significantly associated with nonviral HCC, especially for patients without alcoholism in Taiwan. Because the prevalence of viral HCC is decreasing due to the success of universal vaccination and antiviral therapy, strategies for cancer prevention, prediction, and surveillance for HCC will require modification. (Hepatology Communications 2018;2:747‐759)

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Section: Discussioncontrasting

confidence: 99%

Section: Discussionsupporting

confidence: 88%

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Metabolic risk factors are associated with non‐hepatitis B non‐hepatitis C hepatocellular carcinoma in Taiwan, an endemic area of chronic hepatitis B

Huang

Chang

Hong

et al. 2018

Hepatology Communications

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“…The background livers in most cases show steatosis or steatohepatitis. In many tumors, however, the steatohepatitic changes are more striking in the tumor than in the background nonneoplastic liver tissues [ 106 ].…”

Section: Defi Nitionmentioning

confidence: 99%

Hepatocellular Carcinoma

Torbenson¹

2015

Surgical Pathology of Liver Tumors

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Hepatocellular carcinoma is the most common primary malignant tumor of the liver. Although usually morphologically distinct, hepatocellular carcinomas can demonstrate various histologic patterns, which sometimes create diagnostic challenges for the surgical pathologist. In addition, a number of subtypes are discussed in this chapter, along with typical hepatocellular carcinoma. This chapter examines the clinical, gross, and microscopic features of hepatocellular carcinoma and its variants with illustrated examples. The differential diagnosis of hepatocellular carcinoma is also covered, with a detailed discussion of the various special stains used in the diagnosis of hepatocellular carcinoma and their respective utilities and limitations. Important prognostic factors, including grading of hepatocellular carcinoma, are also reviewed.

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“…Patients with NAFLD-related cirrhosis have an increased risk of developing HCC with incidence of 2-3% per year [35]. A recently described histological variant of HCC, steatohepatitic HCC, is characterized by HCC exhibiting features of steatohepatitis [steatosis in more than 5% of tumour cells, hepatocellular ballooning, Mallory-Denk bodies, intratumoral inflammatory infiltrate and perisinusoidal fibrosis], and associated with underlying NAFLD and metabolic risks [36,37] (Figure 2I). …”

Section: Other Pathological Lesions In Nafldmentioning

confidence: 99%

Pathology of Non-Alcoholic Fatty Liver Disease

Wang¹,

Yu²,

Chan

2016

Int J Dig Dis

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Hepatocellular carcinoma with steatohepatitic features: a clinicopathological study of Japanese patients

Abstract: SH-HCC is a subcategory of HCC associated with the patient's metabolic condition and the presence of steatosis or steatohepatitis in the background liver. Steatohepatitic features were not a significant prognostic factor for HCCs.

Cited by 84 publications

References 17 publications

Metabolic risk factors are associated with non‐hepatitis B non‐hepatitis C hepatocellular carcinoma in Taiwan, an endemic area of chronic hepatitis B

Metabolic risk factors are associated with non‐hepatitis B non‐hepatitis C hepatocellular carcinoma in Taiwan, an endemic area of chronic hepatitis B

Hepatocellular Carcinoma

Pathology of Non-Alcoholic Fatty Liver Disease

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