Hepatocellular carcinoma with intracranial metastasis in a Japanese macaque (Macaca fuscata)

Abstract

To our knowledge, this is the first case report of HCC with intracranial metastasis in a macaque.

Hepatocellular carcinoma in a free‐living marmoset (Callithrix sp.) with concomitant biliary trematodiasis

“…Hepatocellular carcinoma (HCC) has been reported in seven of approximately 300 extant NHP species . The etiology in most of these cases was undetermined.…”

“…37 Hepatocellular carcinoma (HCC) has been reported in seven of approximately 300 extant NHP species. [6][7][8][9][10][11][12][13][14][15][16][17][18] The etiology in most of these cases was undetermined. In the present case, investigation of HBV, HCV, and AFB1 exposure by IHC was negative.…”

“…Experimentally induced or naturally occurring HCC has been reported in chimpanzees ( Pan troglodytes ); common squirrel monkey ( Saimiri sciureus ) and black‐capped squirrel monkey ( Saimiri boliviensis ); cynomolgous ( Macaca fascicularis ), rhesus ( Macaca mulata ), and Japanese macaques ( Macaca fuscata ); African green monkey ( Cercopithecus aethiops ); and golden‐headed lion tamarins ( Leontopithecus chrysomelas ) . Other PLNs reported in NHPs are hepatoma in sooty mangabey ( Cercocebus atys ); neuroendocrine carcinoma in baboon ( Papio sp.…”

Hepatocellular carcinomas in captive prosimians

“…HCCs have been described in 3 male cynomolgus monkeys (Macaca fascicularis) of about 5 years old, 38,55 2 chimpanzees (Pan troglodytes) including 1 animal infected with Schistosoma mansoni, 1,36 a female rhesus monkey (Macaca mulatta) fed aflatoxin B1 for 6 years, 2 a female squirrel monkey (Saimiri sciureus), 31 2 aged squirrel monkeys (Saimiri boliviensis) for which 1 of the 2 had concurrent cirrhosis and pulmonary metastases, 7 and an adult male Japanese macaque (Macaca fuscata) with intracranial metastasis. 30 Making a distinction between a primary versus metastatic hepatic neoplasia can be challenging. To enhance the diagnostic accuracy, immunohistochemical studies have been conducted in human hepatic tissues.…”