Hepatocellular carcinoma surveillance: Eastern and Western perspectives

Purcell, Yvonne; Copin, P.; Paulatto, Luisa; Pommier, Romain; Vilgrain, Valérie; Ronot, Maxime

doi:10.14366/usg.18043

Cited by 12 publications

(9 citation statements)

References 60 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The adherence practice of HCC surveillance among high-risk chronic liver disease patients in our study was generally lower compared with those of other studies. 25 Several countries have engaged in nationwide systematic and active use of HCC surveillance programs, 26 but China Figure 3 Reasons for not performing HCC surveillance in primary health centers.…”

Section: Discussionmentioning

confidence: 99%

<p>Adherence to Hepatocellular Carcinoma Surveillance and Perceived Barriers Among High-Risk Chronic Liver Disease Patients in Yunnan, China</p>

Dai¹,

Zhao²,

Du³

et al. 2020

CMAR

View full text Add to dashboard Cite

Background: Data concerning adherence to hepatocellular carcinoma (HCC) surveillance among chronic liver disease (CLD) patients at high risk of developing HCC in China are limited. We aimed to examine the relationship between HCC-related knowledge dimensions and adherence to HCC surveillance procedures among chronic liver disease patients at high risk of developing HCC and to identify potential barriers. Methods: A total of 380 patients with chronic liver disease at high risk of developing HCC were recruited between May and August 2018 to complete a survey during the first week of their first hospitalization at the Third People's Hospital of Kunming in China. We followed up each patient up to 7 months by telephone to confirm whether the patient returned to complete investigations for HCC surveillance. Patient's socio-demographic characteristics, HCC-related knowledge, and perceived barriers to HCC surveillance were measured using a structured questionnaire during their hospitalization. Factor analysis was performed on the knowledge questions to reduce the dimensions. Univariate and multivariate analyses were performed to examine the association between dimensions of HCC-related knowledge and patients' adherence to HCC surveillance. Results: A total of 327 eligible patients had been successfully contacted in the follow-up phase. Only a quarter of patients completed HCC surveillance within 7 months after their first admission to hospital. High costs and perceived poor test efficacy were the two major barriers for HCC surveillance. Three common factors were derived from the factor analysis of HCCrelated knowledge, namely, "Surveillance", "Lifestyle", and 'Prognosis'. Knowledge of HCC surveillance and lifestyle but not prognosis had an influence on adherence to HCC surveillance. Patients with better surveillance and lifestyle knowledge domain had better adherence to HCC surveillance. Conclusion: Adherence to HCC surveillance procedures is low in the study area. Closing the gap in HCC-related knowledge, particularly regarding surveillance and lifestyle, may help to increase adherence rates.

show abstract

Section: Discussionmentioning

confidence: 99%

<p>Adherence to Hepatocellular Carcinoma Surveillance and Perceived Barriers Among High-Risk Chronic Liver Disease Patients in Yunnan, China</p>

Dai¹,

Zhao²,

Du³

et al. 2020

CMAR

View full text Add to dashboard Cite

show abstract

“…According to the AASLD 2018 practice guideline, ultrasonography (US) is recommended as a surveillance tool in patients at risk for HCC [ 2 , 5 ]. The US LI-RADS system was developed to provide guidance regarding the performance, interpretation, and reporting of US examinations conducted for surveillance [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

US LI-RADS visualization score: diagnostic outcome of ultrasound-guided focal hepatic lesion biopsy in patients at risk for hepatocellular carcinoma

et al. 2021

View full text Add to dashboard Cite

This study investigated the diagnostic outcome of ultrasound (US)-guided focal hepatic lesion biopsy in patients at risk for hepatocellular carcinoma (HCC) and evaluated the US visualization score as a risk factor for non-diagnostic results. Methods: We retrospectively evaluated 208 focal hepatic lesions in 208 patients who underwent US-guided biopsy in 2016. Using the US Liver Imaging Reporting and Data System version 2017, each exam was assigned a US visualization score (A, B, or C). Final diagnoses were made using pathology reports, and biopsy results were categorized as diagnostic or non-diagnostic. Univariable and multivariable analyses were performed to determine risk factors for nondiagnostic results, including US visualization score and other clinical covariates. Results: Of the 208 lesions, 85.1% were diagnostic and 14.9% were non-diagnostic. The rates of non-diagnostic results were 8.9%, 25.5%, and 57.1% for scores of A, B, and C, respectively. In the univariable analysis, scores of B or C were associated with a significantly higher rate of nondiagnostic results than scores of A (58.1% vs. 24.9%, P<0.001). In the multivariable analysis, US visualization score of B or C (adjusted odds ratio [aOR], 2.7; P=0.027), high-risk needle pathway usage (aOR, 5.7; P=0.001), and lesion size ≤2.0 cm (aOR, 2.7; P=0.024) were independent risk factors for non-diagnostic results. Conclusion: US-guided biopsy had a high diagnostic yield for focal hepatic lesions in patients at risk for HCC. US visualization score of B or C, lesion size ≤2.0 cm, and high-risk needle pathway usage were independent risk factors for non-diagnostic results.

show abstract

“…In contrast to other cancers, no centralised HCC surveillance and prevention programs exist in any Western country. 35 Coordination of surveillance is dependent on local protocols Conversely, Japan and South Korea have implemented centralised health promotion and surveillance programs. The Japanese program was implemented over 30 years ago, and includes public awareness campaigns, dedicated educators, and free hepatitis testing and surveillance.…”

Section: System Barriersmentioning

confidence: 99%

Hepatocellular carcinoma surveillance in Australia: current and future perspectives

Hui,

Bell,

et al. 2023

Medical Journal of Australia

View full text Add to dashboard Cite

Summary Hepatocellular carcinoma (HCC) is a leading cause of cancer‐related death worldwide, and is increasing in incidence in Australia. For most people with cirrhosis and chronic hepatitis B, HCC screening and surveillance is recommended with 6‐monthly ultrasound. However, most patients with HCC are still diagnosed outside of surveillance with incurable disease. While HCC surveillance almost certainly reduces cancer‐related mortality, the potential harms of surveillance are incompletely understood. Surveillance uptake remains suboptimal in many contexts, and stems from a combination of patient, clinician and system level barriers. Improved case‐finding strategies may be required to identify high risk individuals in need of surveillance, as cirrhosis and viral hepatitis are often asymptomatic. HCC prediction models and novel surveillance tools such as biomarker panels, computed tomography and magnetic resonance imaging may have a future role in personalised HCC surveillance. Analyses suggest surveillance may be cost‐effective, but Australian data remain limited. A centralised HCC surveillance program may ultimately have a role in delivering improved and more equitable care.

show abstract

Hepatocellular carcinoma surveillance: Eastern and Western perspectives

Cited by 12 publications

References 60 publications

<p>Adherence to Hepatocellular Carcinoma Surveillance and Perceived Barriers Among High-Risk Chronic Liver Disease Patients in Yunnan, China</p>

<p>Adherence to Hepatocellular Carcinoma Surveillance and Perceived Barriers Among High-Risk Chronic Liver Disease Patients in Yunnan, China</p>

US LI-RADS visualization score: diagnostic outcome of ultrasound-guided focal hepatic lesion biopsy in patients at risk for hepatocellular carcinoma

Hepatocellular carcinoma surveillance in Australia: current and future perspectives

Contact Info

Product

Resources

About