Hepatocellular Carcinoma Multidisciplinary Clinic-Cairo University (HMC-CU) score: A new simple score for diagnosis of HCC

Abdelaziz, Ashraf Omar; Nabil, Mohamed; Omran, Dalia; Abdelmaksoud, Ahmed Hosni; Asem, Noha; Shousha, Hend Ibrahim; Elbaz, Tamer; Lithy, Rania

doi:10.1016/j.ajg.2020.04.001

Cited by 9 publications

(9 citation statements)

References 32 publications

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“…the Hepatocellular Carcinoma Multidisciplinary Clinic-Cairo University (HMC-CU) score. 28 Whether the score applies in the Chinese population needs to be further verified. Also, DCP and sAXL AFP, alpha-fetoprotein; APRI, aminotransferase-to-platelet ratio index; CI, confidence interval; DCP, des-γ-cboxy prothrombin; GPR, gamma-glutamyl transpeptidaseto-platelet ratio; HCC, hepatocellular carcinoma; OR, odds ratio; sAXL, soluble AXL.…”

Section: Discussionmentioning

confidence: 99%

Diagnostic Efficacy and Possible Underlying Mechanisms of Noninvasive Clinical Markers in Hepatocellular Carcinoma

Fu¹,

Li²,

Chen³

et al. 2023

J Clin Transl Hepatol

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Background and Aims:In this study, we aimed to evaluate the diagnostic values of alpha-fetoprotein (AFP), soluble AXL (sAXL), des-γ-carboxy prothrombin (DCP), the aspartate aminotransferase-to-platelet ratio index (APRI), and the gamma-glutamyl transpeptidase-to-platelet ratio (GPR) in hepatocellular carcinoma (HCC) and the possible underlying mechanisms of the correlations between them. Methods: We collected serum samples from 190, 128, and 75 patients with HCC, cirrhosis, and chronic viral hepatitis, and from 82 healthy subjects. Serum levels of AFP, sAXL, and DCP were determined, and APRI and GPR values were calculated. Receiver operating characteristic (ROC) curves were used to analyze the diagnostic value of single and combined biomarkers. Results: We detected significant differences between the HCC group and other groups regarding serum AFP, sAXL, DCP, and APRI levels. GPR significantly differed between the HCC group and other groups, except for the liver cirrhosis group. AFP, sAXL, DCP, APRI, and GPR had positive correlations with each other, and AFP showed a higher area under the curve (AUC) and Youden index values, while APRI and DCP showed the highest sensitivity and specificity. Also, when AFP was combined with sAXL, DCP, APRI, and GRP, the highest AUC (0.911) and a higher net reclassification improvement value were obtained compared with those obtained for the individual biomarkers. Conclusions: AFP, sAXL, DCP, APRI, and GPR are independent risk factors for

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Section: Discussionmentioning

confidence: 99%

Diagnostic Efficacy and Possible Underlying Mechanisms of Noninvasive Clinical Markers in Hepatocellular Carcinoma

Fu¹,

Li²,

Chen³

et al. 2023

J Clin Transl Hepatol

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“…Of note in our earlier work, CRS, APRI and FIB4 parameters discriminated between HCC and no HCC in HCV infected patients [ 18 ]. The role of other clinical factors on the prediction of liver cancer has been studied [ 33 ]. In this regard, study concluded a novel score (HMC-CU) for the diagnosis of HCC in a complete absence of genetic determinants; utilizing AFP, age, gender, haemoglobin, s-albumin, INR levels [ 33 ].…”

Section: Discussionmentioning

confidence: 99%

Seven gene signature explores the impact of DAAs on the appearance of hepatocellular carcinoma in HCV infected patients

Dawood

El-Meguid

Shousha

et al. 2022

Heliyon

Self Cite

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“…A scoring system was suggested by Abdelaziz et al [ 126 ]. The HCC Multidisciplinary Clinic-Cairo University (HMC-CU) score (Logit probability of HCC = -2.524 + 0.152 × age -0.121 × Hb -0.696 × INR -1.059 × Alb + 0.022 × AFP + 0.976 × Sex.…”

Section: Hcc Screeningmentioning

confidence: 99%

Unique situation of hepatocellular carcinoma in Egypt: A review of epidemiology and control measures

Ezzat¹,

Eltabbakh²,

Kassas³

2021

WJGO

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Hepatocellular carcinoma (HCC) is the sixth most common primary malignancy worldwide, and the third most common cause of death among cancers worldwide. HCC occurs in several pre-existing conditions, including hepatitis C, hepatitis B virus, and non-alcoholic cirrhosis. Egypt used to be the country with the heaviest hepatitis C virus (HCV) burden. The relationship between HCV and HCC is an important research area. In Egypt, HCC is a significant public health problem. A possible cause for the increasing rates of detection of HCC in Egypt is the mass screening program that was carried by the government for detecting and treating HCV. A multidisciplinary approach is now widely applied to HCC management in health centers all over Egypt. Different treatment modalities are available in Egypt, with success rates comparable to global rates. The Egyptian health authorities have made the elimination of HCV from Egypt a special priority, and this approach should lead to a decrease in number of HCC cases in the near future. In this article we review the current situation of HCC in Egypt, including epidemiological aspects, relevant risk factors for HCC development, strategies, and efforts established by health authorities for the screening and prevention of both HCV and HCC in Egypt. We highlight the different modalities for HCC treatment.

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Hepatocellular Carcinoma Multidisciplinary Clinic-Cairo University (HMC-CU) score: A new simple score for diagnosis of HCC

Cited by 9 publications

References 32 publications

Diagnostic Efficacy and Possible Underlying Mechanisms of Noninvasive Clinical Markers in Hepatocellular Carcinoma

Diagnostic Efficacy and Possible Underlying Mechanisms of Noninvasive Clinical Markers in Hepatocellular Carcinoma

Seven gene signature explores the impact of DAAs on the appearance of hepatocellular carcinoma in HCV infected patients

Unique situation of hepatocellular carcinoma in Egypt: A review of epidemiology and control measures

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