Hepatocellular carcinoma metastatic to the mandible

Takinami, S; Yahata, Hideko; Kanoshima, Akiko; Yamasaki, Michimasa; Funaoka, K.; Nakamura, Eiji; Fujiwara, Toshikatsu; Totsuka, Yasunori

doi:10.1016/s1079-2104(05)80110-6

Cited by 18 publications

(5 citation statements)

References 7 publications

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“…The treatment of pathological mandibular fractures associated with malignant or benign neoplasms has to be directed toward the disease process that must be considered the first priority . Pathological fractures are more frequently associated with metastatic tumors or primary oral squamous cell carcinoma (Table ).…”

Section: Mandibular Fractures Associated With a Malignant Pathology/bmentioning

confidence: 99%

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Pathological mandibular fractures: a review of the literature of the last two decades

Boffano

Roccia

Gallesio

et al. 2013

Dental Traumatology

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Section: Mandibular Fractures Associated With a Malignant Pathology/bmentioning

confidence: 99%

“…Pathological fractures usually may be determined by surgical interventions (third molar removal and implant placement), result from regions of osteomyelitis, osteoradionecrosis (ORN), and bisphosphonate‐related osteonecrosis of the jaw (BRONJ), occur because of idiopathic reasons or be facilitated by cystic lesions, benign, malignant, or metastatic tumors .…”

mentioning

confidence: 99%

Pathological mandibular fractures: a review of the literature of the last two decades

Boffano

Roccia

Gallesio

et al. 2013

Dental Traumatology

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“…[ 8 ] Most oral metastases are associated with lung metastases, and they possibly occur by this hematogenous route. [ 9 ] Another possible pathway of metastasis is an anastomotic network of paravertebral veins that bypasses the pulmonary, inferior caval, and portal venous circulations. [ 10 , 11 ] This pathway may be responsible for metastasis to the vertebral bodies, which are the preferred site of bony HCC metastasis.…”

Section: Discussionmentioning

confidence: 99%

A case report of metastatic hepatocellular carcinoma in the mandible and coracoid process

Radzi

Tan

2018

Medicine

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Rationale:We report a rare case of hepatocellular carcinoma (HCC) with metastases to the mandible and coracoid process of scapula without evidence of lung involvement.Patients concerns:The patient was diagnosed with HCC, presented 5 months later with right lower tooth pain, swelling over the right mandible area and right shoulder pain.Diagnoses:Histopathological examination of mandible showed findings suggestive of metastatic HCC. Magnetic resonance imaging (MRI) of the right shoulder revealed findings of irregular enhancing lesion at the right coracoid process causing erosion of the coracoid process.Interventions:Patient was subsequently referred for palliative medicine care.Outcomes:He received adequate analgesia.Lessons:Oral cavity and scapula metastases from HCC are very rare. Most oral metastases are associated with lung metastases, and they possibly occur by hematogenous route. In our case, the possible pathway of metastasis is an anastomotic network of paravertebral veins that bypasses the pulmonary, inferior caval, and portal venous circulations.

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“…The clinical manifestations of the disease – swelling and hypoesthesia in the distribution territory of the mental nerve – collected in our patient coincide with those reported in other cases. The presence of toothache is more unusual [12, 15].…”

Section: Clinical Featuresmentioning

confidence: 99%

Mandibular Metastasis as the First Manifestation of Hepatocellular Carcinoma: A Case Report

Fernández-Ferreira

Savage-Leyva²,

Durán-Guerrero

et al. 2023

Case Rep Oncol

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Metastatic malignancies of the oral cavity are rare lesions, accounting for only 1–4% of all oral malignancies, and can occur in the jaw bones, the oral soft tissues, or even both. Although hepatocellular carcinoma is the most common primary hepatic tumor, no more than 1% of the cases show oral involvement. When metastatic tumor involves the oral cavity, the most frequent site is the posterior angle of the mandible. Histologically, hence, immunohistochemical markers are used for diagnosis. Glypican-3 and HepPar1 are the markers that can be used to confirm the microscopic diagnosis of HCC. Very rarely, hepatocellular carcinoma (HCC) metastasizes to the oral cavity, and such cases have a poor prognosis due to delay in diagnosis. We present a 74-year-old male with a metastasis of HCC in the left mandibular body as the first manifestation. Histologic examination confirmed metastatic hepatocellular carcinoma in the oral mucosa with immunohistochemical (IHC) markers. A review of pertinent literature was performed. Given the rarity of the disease, treatment principles are based mainly on retrospective series and case reports. We report an exceptionally unusual presentation with few cases (<70) reported in the literature, thus representing a diagnostic challenge.

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Hepatocellular carcinoma metastatic to the mandible

Cited by 18 publications

References 7 publications

Pathological mandibular fractures: a review of the literature of the last two decades

Pathological mandibular fractures: a review of the literature of the last two decades

A case report of metastatic hepatocellular carcinoma in the mandible and coracoid process

Mandibular Metastasis as the First Manifestation of Hepatocellular Carcinoma: A Case Report

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