A case report of metastatic hepatocellular carcinoma in the mandible and coracoid process

Abstract

Rationale:We report a rare case of hepatocellular carcinoma (HCC) with metastases to the mandible and coracoid process of scapula without evidence of lung involvement.Patients concerns:The patient was diagnosed with HCC, presented 5 months later with right lower tooth pain, swelling over the right mandible area and right shoulder pain.Diagnoses:Histopathological examination of mandible showed findings suggestive of metastatic HCC. Magnetic resonance imaging (MRI) of the right shoulder revealed findings of irregular enhancing lesion at the right coracoid process causing erosion of the coracoid process.Interventions:Patient was subsequently referred for palliative medicine care.Outcomes:He received adequate analgesia.Lessons:Oral cavity and scapula metastases from HCC are very rare. Most oral metastases are associated with lung metastases, and they possibly occur by hematogenous route. In our case, the possible pathway of metastasis is an anastomotic network of paravertebral veins that bypasses the pulmonary, inferior caval, and portal venous circulations.

Breast Metastasis in a Patient with Primary Hepatocellular Carcinoma

“…The incidence of hepatocellular carcinoma varies among geographical areas, with greater incidence being found in Asia, Taiwan, Korea, China and Japan [1][2][3][4][5][6][7]. Advanced hepatocellular carcinoma is one of the most lethal diseases and includes metastases to various organs, such as lungs, lymph nodes, musculoskeletal structures, peritoneal surface, gastrointestinal tract, spleen and pancreas [7][8][9][10].…”

“…Hepatocellular carcinoma (HCC), is the 4 th most common neoplasm in men and 9th most common neoplasm in women, making it one of the leading causes of cancer-related deaths (approximately 600.000 deaths/year worldwide) [1][2][3][4][5][6][7][8][9][10][11][12]. Its geographical distribution varies according to the prevalence of known aetiologic factors such as HBV, HCV infection, alcohol, cirrhosis [12].…”

Perfil Epidemiológico Das Fissuras Orofaciais No Brasil

“…Qualquer neoplasia maligna pode promover a formação de tumores metastáticos para os tecidos do sistema estomatognático, no entanto, a literatura mostra uma maior ocorrência de TMSE associados a neoplasias primárias localizadas em mama, próstata, pulmão, tireoide e rim, perfazendo cerca de 70% dos casos (WU et al, 2017) As metástases de carcinomas pulmonares são mais frequentemente detectados em estágio metastático IV em localizações extra-gnáticas como o fígado, ossos, glândulas suprarrenais e cérebro, no entanto, sugere-se que as lesões metastáticas para a região de cabeça e pescoço usualmente associam-se a tumores primários localizados nos pulmões, com destaque para o carcinoma de células escamosas, seguido do adenocarcinoma (DJERIC et al, 2015;CHENG et al, 2017;MATSUDA, 2018;RADZI, TAN, 2018). Por outro lado, sugere-se que tumores primários do pulmão, pleura, brônquios, esôfago, cólon, mama e pele geralmente metastatizam para a língua (DANIC, DANIC, MACAN, 2018).…”

Tumores Metastáticos No Sistema Estomatognático

“…Os TMSE que comprometem os tecidos do sistema estomatognático exibem uma incidência variando de 1 a 8% de todas as malignidades orais (VARADARAJAN et al, 2017;DANIC, DANIC, MACAN, 2018;RADZI, TAN, 2018;PELISSARI et al, 2018), são relativamente raros, por esse motivo representam um desafio diagnóstico. Aproximadamente 30% dos casos de TMSE constituem o primeiro sinal de disseminação metastática de uma neoplasia primária muitas vezes desconhecida até o momento do diagnóstico da lesão metastática (SANCHEZ-JIMÉNEZ et al, 2005;MUTTAGI et al, 2011).…”