Hepatobiliary Tumors: Update on Diagnosis and Management

Kabbach, Ghassan; Assi, Hussein; Bolotin, G.; Schuster, Michael; Lee, Hwa Jeong; Tadros, Micheal

doi:10.14218/jcth.2015.00012

Cited by 40 publications

(23 citation statements)

References 114 publications

(134 reference statements)

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“…In addition, patients with malignancy might largely benefit from taking regular nonsteroidal anti-inflammatory drugs such as aspirin 39,40. Additionally, HBV infection is closely related to HCC occurring in the East and mediate the consistent expression of HBV immunogenic proteins, resulting in a potent systematic inflammatory 2. Similar to previous results in our study, we observed that the patients with HBV infection had significantly worse OS compared with counterparts with no HBV infection.…”

Section: Discussionsupporting

confidence: 87%

“…Hepatocellular carcinoma (HCC) is one of the most prevalent malignancies, with increasing incidence and mortality worldwide 1,2. Curative resection, which might significantly ameliorate the prognosis of patients with HCC, is a potentially effective treatment strategy.…”

Section: Introductionmentioning

confidence: 99%

“…Curative resection, which might significantly ameliorate the prognosis of patients with HCC, is a potentially effective treatment strategy. However, the majority of persons have lost the chance of accepting curative surgery due to the clinical characteristics of HCC, including easy local invasion, lymph node, vascular, distant metastasis, and no symptom in the early days 2–4. Despite improved diagnostic and treatment strategy, the prognosis of patients with HCC suffering from hepatic carcinectomy remains poor, which indicated that those patients had not benefited from the operation 5.…”

Section: Introductionmentioning

confidence: 99%

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Prognostic significance of pretreatment albumin/globulin ratio in patients with hepatocellular carcinoma

Deng¹,

Pang²,

Miao³

et al. 2016

OTT

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BackgroundPretreatment nutritional and immunological statuses play an indispensable role in predicting the outcome of patients with various types of malignancies. The purpose of this study is to evaluate the predictive value of albumin/globulin ratio (AGR) in overall survival (OS) and recurrence in patients with hepatocellular carcinoma (HCC) following radical hepatic carcinectomy.Patients and methodsThis retrospective study included a total of 172 patients with HCC with complete medical and follow-up information between 2002 and 2012. AGR was calculated according to the following formula: AGR = albumin/globulin. Receiver operating characteristic curve analysis was performed to determine the optimal cutoff value. The associations of AGR with clinicopathological characteristics and prognosis were assessed. Further multivariate analysis using Cox regression model and subgroup analysis was performed to evaluate the predictive value.ResultsReceiver operating characteristic curve determined 37.65, 31.99, and 1.48 as the optimal cutoff values of albumin, globulin, and AGR in terms of 5-year OS or death, respectively. On the basis of the cutoff value of AGR, all the patients were divided, respectively, into low-AGR (n=105) and high-AGR (n=67) groups. AGR was found to be significantly correlated with age, cancer embolus, international normalized ratio, and postoperative outcome (P<0.05). Hepatitis B virus infection (hazard ratio [HR]: 2.125; 95% confidence interval [CI]: 1.285–3.153), tumor node metastasis stage (HR: 1.656; 95% CI: 1.234–2.223), serum albumin (HR: 0.546; 95% CI: 0.347–0.857), and AGR (HR: 0.402; 95% CI: 0.233–0.691) were independent predictors of OS via univariate and multivariate survival analyses. However, alpha-fetoprotein (HR: 1.708; 95% CI: 1.027–2.838), tumor node metastasis stage (HR: 1.464; 95% CI: 1.078–1.989), and AGR (HR: 0.493; 95% CI: 0.293–0.828) functioned as independent risk variables for predicting recurrence. Moreover, AGR showed superior prognostic value for OS and recurrence in the subgroups with normal level of albumin or survival time beyond 6 months.ConclusionPretreatment AGR might serve as an effective biomarker to evaluate the prognosis of patients with a diagnosis of HCC. Based on the results, AGR, characterized with easy accessibility, objectivity, and noninvasiveness, should be included in the routine assessment of HCC.

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Section: Discussionsupporting

confidence: 87%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Prognostic significance of pretreatment albumin/globulin ratio in patients with hepatocellular carcinoma

Deng¹,

Pang²,

Miao³

et al. 2016

OTT

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“…However, in the worldwide, the 5-year overall survival (OS) rate of HCC is only 7% 2 . To date, many serum biomarkers, such as α-fetoprotein (AFP), γ-glutamyl transferase (GGT), and (carcino-embryonic antigen) CEA, have been used to predict the survival of HCC patents 3 , 4 . Especially, AFP is the widely used tumor biomarker for HCC prognosis.…”

Section: Introductionmentioning

confidence: 99%

A retrospective discussion of the prognostic value of combining prothrombin time(PT) and fibrinogen(Fbg) in patients with Hepatocellular carcinoma

Wang¹,

Mao²,

He³

et al. 2017

J. Cancer

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Aims: The levels of coagulation system tests have been studied in various cancers. In this study, our aim is to evaluate the prognostic value of pretreatment plasma coagulation tests in hepatocellular carcinoma (HCC) patients. Patient and methods: A retrospective study was performed in 539 patients with HCC, and follow-up period was at least 60 months until recurrence or death. The prognostic significance of coagulation system tests (prothrombin time, activated partial thromboplastin time, thrombin time, fibrinogen) were determined by univariate and multivariate Cox hazard models. Then, according to the results of the multivariate analyses, we proposed the coagulation-Based Stage, which combined the independent risk factors (prothrombin time and fibrinogen). Results: Coagulation system tests including prothrombin time (PT), activated partial thromboplastin time (APTT), thrombin time (TT), fibrinogen (Fbg) were analyzed. Patients with prolonged PT (≥12.1 sec) levels had significantly poor overall survival (OS) and disease-free survival (DFS), not only in the entire cohort (HR: 1.661, 95%CI: 1.125-2.451, p=0.011 vs. HR: 1.660, 95%CI: 1.125-2.451, p=0.011), but also in the subgroups stratified by pathological stage (stage I-II and stage III-IV). Additionally, high Fbg (≥2.83 g/L) levels experienced significantly decreased OS and DFS (HR: 2.158, 95%CI: 1.427-3.263, p<0.001 vs. HR: 2.161, 95%CI: 1.429-3.267, p<0.001), not only in the entire cohort but also in the subgroups stratified by pathological stage (stage I-II and stage III-IV). All the patients were then stratified (based on combined PT and Fbg) into three groups, The OS for HCC patients were (41.37±17.76), (31.83±19.84) and (18.68±18.41) months, and the DFS for HCC patients were (41.15±17.88), (31.65±19.81) and (18.66±18.39) months. Conclusions: Our findings suggest that the combination of plasma PT and Fbg levels should be evaluated as the valuable predictor of survival in patients with HCC.

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“…Clinical features of the disease are determined by location and clinical stage. CCAs are divided by location from the surgical perspective into intrahepatic and extrahepatic types [3, 4]. On the other hand, clinical staging which is essential for treatment and prognosis [5], depends on size, lymph node invasion, and metastasis to other tissues.…”

Section: Introductionmentioning

confidence: 99%

ZHX1 Promotes the Proliferation, Migration and Invasion of Cholangiocarcinoma Cells

et al. 2016

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Zinc-fingers and homeoboxes 1 (ZHX1) is a transcription repressor that has been associated with the progressions of hepatocellular carcinoma, gastric cancer, and breast cancer. However, the functional roles of ZHX1 in cholangiocarcinoma (CCA) have not been determined. We investigated the expression and roles of ZHX1 during the proliferation, migration, and invasion of CCA cells. In silico analysis and immunohistochemical studies showed amplification and overexpression of ZHX1 in CCA tissues. Furthermore, ZHX1 knockdown using specific siRNAs decreased CCA cell proliferation, migration, and invasion, whereas ZHX1 overexpression promoted all three characteristics. In addition, results suggested EGR1 might partially mediate the effect of ZHX1 on the proliferation of CCA cells. Taken together, these results show ZHX1 promotes CCA cell proliferation, migration, and invasion, and present ZHX1 as a potential target for the treatment of CCA.

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Hepatobiliary Tumors: Update on Diagnosis and Management

Cited by 40 publications

References 114 publications

Prognostic significance of pretreatment albumin/globulin ratio in patients with hepatocellular carcinoma

Prognostic significance of pretreatment albumin/globulin ratio in patients with hepatocellular carcinoma

A retrospective discussion of the prognostic value of combining prothrombin time(PT) and fibrinogen(Fbg) in patients with Hepatocellular carcinoma

ZHX1 Promotes the Proliferation, Migration and Invasion of Cholangiocarcinoma Cells

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