Hepato-renal protective effect of vitamin C against toxicity induced by ceftriaxone in rats

Ibrahim, Hosny A.; Shehata, E. I.; Mohammed, Heba

doi:10.21608/bvmj.2019.103403

Cited by 1 publication

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“…In this work, the fourth group when the rats were received Vitamin C only, there were no obvious histological changes in both hepatic and renal tissue in agreement with the results of other study [22]. It was clear that Vitamin C as the most effective antioxidant in avoiding lipid peroxidation and a potent free-radical scavenger [23], [24].…”

Section: Discussionsupporting

confidence: 87%

The Role of Vitamin C in Amelioration of Hepatorenal Toxicity of Cefotaxime in Adult Albino Rats (Histological Study)

Sammak¹,

Ahmed

Alazzo

2021

Open Access Maced J Med Sci

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AIM: Antibiotics have a great risk property, for this reason, the present work aimed to study the toxic effect of cefotaxime on histological examination of liver and kidney tissues as well as to detect the protecting role of Vitamin C. METHODS: Thirty-two male adult albino rats were divided into four groups each with (eight animals) as following: Group (1): As control group and they injected with normal saline. Group (2): They were injected with 200 mg/kg B.W. of cefotaxime. Group (3): They were injected with Vitamin C in dose 100 mg/kg B.W. 1 h before they inject with 200 mg/kg B.W. of cefotaxime. Group (4): It was given Vitamin C in dose of 100 mg/kg B.W. Animals in all groups were injected intraperitoneally as single daily dose for 14 consecutive days. RESULTS: Results of cefotaxime treated group revealed that a significant liver tissue changes as hepatocytic vacuolation, necrosis, cholestasis with sinusoidal congestion, and dilatation also induced a histopathological change in the kidney including tubular epithelial degeneration, cast formation in renal tubules, inflammatory cells infiltration in the interstitium, and few glomeruli showed eosinophilic material deposition at the wall of bowman capsule. Adding Vitamin C to third group induces amelioration in the histological features of liver and kidney seen in Group (2) while group of Vitamin C only showed a histological picture similar to control group. CONCLUSION: From this study, we can conclude that Vitamin C has important hepato-renal protective effect.

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Section: Discussionsupporting

confidence: 87%