Hepato-protective potentials of Sterculia setigera stem-bark extract on acetominophen induced hepato toxicity in Wistar albino rats

Garba, Mikail Hudu; Sherifat, M L; Abdul-Majeed, Abdullah; Hafsa, L M; Awal, Abdul; Saâ€TMadu, A A; Lekene, B J

doi:10.5897/jmpr2018.6672

Cited by 4 publications

(6 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For example, Annona senegalensis, Anogeissus leiocarpus, Carica papaya, Psidium guajava, Cochlospermum planchonii, and Vernonia amygdalina induced hepatoprotective activity against CCl4 induced hepatotoxicity (Adesanoye and Ã, 2010; Akanbi et al, 2014;Aliyu et al, 1995;Dotto and Abihudi, 2021;Gutiérrez et al, 2008;Omeke et al, 2019). Similarly, Calotropis procera, Cassia occidentalis, Luffa cylindrica, Sterculia setigera were hepatoprotective against paracetamol-induced liver toxicity (Garba et al, 2018;Meena et al, 2011;Sharma et al, 2014;Yadav et al, 2010). Furthermore, as shown in Table 3 there are plants cited herein that also induced hepatoprotective effect against various types of induced liver toxicity.…”

Section: Ph Ravenmentioning

confidence: 75%

“…To treat liver disease in Togo (Kpodar et al, 2016) The aqueous leaf extract at 500mg/kg induced significant hepatoprotective effect against carbon tetrachloride induced liver damage (Gutiérrez et al, 2008) The LD50 of guava leaf extract is more than 5g/kg in rat and mice (Gutiérrez et al, 2008) Sterculia setigera Delile To treat Jaundice (Babalola et al, 2012) Stem bark extract induced hepatoprotective effect against acetaminophen induced hepatotoxicity in rats (Garba et al, 2018) The aqueous stem bark extract did not significantly change biochemical parameters in Wistar rats (Zaruwa et al, 2016) Tamarindus indica L.…”

Section: Ph Ravenmentioning

confidence: 99%

See 1 more Smart Citation

Ethnomedicinal study and in vitro validation of medicinal plants used for treating Jaundice in Zuru emirate of Kebbi State, Nigeria

Danjuma

Abubakar

Nwaogu

et al. 2022

Annals of Science and Technology

View full text Add to dashboard Cite

Background: For decades, the resident of Zuru emirate have used herbal medicine to treat liver-related diseases including jaundice. Therefore, the present study was designed to investigate and document the herbal medicine used for treating jaundice in Zuru emirate. Method: Oral interviews and questionnaire were used to document information on medicinal plants, medicinal practices, and demographic profiles of respondents. The medicinal plants that were mentioned were collected, identified, and assigned voucher numbers. The names were further authenticated using www.theplantlist.org and theworldfloraonline.org. Thereafter, the methanol stem bark extracts of three of the most frequently mentioned plants were subjected to in vitro bilirubin degradation assay. Result: A total of 46 TMPs Traditional medicine practitioners responded and cited 28 medicinal plants and medicinal practices used to treat jaundice. The most frequently mentioned plants were Erythrina senegalensis (19.6%) followed by Cochlospermum planchonii (13%), and Anogeissus leiocarpus (13%). The herbal remedies were prepared using different parts of the plants as boiled juice or powder and mostly taken as juice with pap or fresh raw cow milk. The in vitro bilirubin degradation assay revealed a time-dependent and dose-dependent bilirubin degradation by Anogeissus leiocarpus (63.05 %), Erythrina senegalensis (46.33%), and Cochlospermum planchonii (27.45%). Conclusion: The present findings revealed the medicinal plants that are used to treat jaundice and the potential jaundice ameliorative effect of these plants may involve bilirubin degradation. Future in vitro and in vivo mechanistic studies should investigate the jaundice ameliorative potency of these plants.

show abstract

Section: Ph Ravenmentioning

confidence: 75%

Section: Ph Ravenmentioning

confidence: 99%

Ethnomedicinal study and in vitro validation of medicinal plants used for treating Jaundice in Zuru emirate of Kebbi State, Nigeria

Danjuma

Abubakar

Nwaogu

et al. 2022

Annals of Science and Technology

View full text Add to dashboard Cite

show abstract

“…Cold extraction was performed using methanol as solvent. The preparation of the crude extract was based on the method described by Garba et al (2018): Fifty grams (50g) of the dried sample was pulverized to powdered form and cold extracted in 700 ml of methanol. Extraction lasted for 48 hours.…”

Section: Preparation Of Plant Extractmentioning

confidence: 99%

PROPHYLACTIC POTENCY OF METHANOLIC EXTRACT OF Momordica balsamina L. AGAINST AVIAN PARAMYXOVIRUS-1 INFECTION IN BROILER CHICKENS

Ampitan

Garba²,

Adekambi³

et al. 2023

Egyptian Journal of Animal Production

View full text Add to dashboard Cite

The potency of Momordica balsamina extract against avian paramyxovirus-1 (Newcastle Disease Virus) (Kudu 113) was investigated in this study. Thirty, 5-week-old broiler birds were used for the experiment and were grouped in a completely randomised design with each group consisting of 5 birds. Group, I was a positive control, and group II was the negative control. The extract was administered prophylactically at doses of 200, 250, 300 and 350 mg/kg bw to groups III to VI respectively. Thereafter, all the groups were challenged with the strain of ND (Kudu 113) virus on seventh week to induce infection. The birds were monitored for 21 days for the symptoms of Newcastle Disease. No hemorrhagic lesion on the liver of all the groups administered with the extract was observed except group III which was administered 200 mg/kg BW of the extract. The mortality rate was 20% in group VI and 40% in group V. The clinical sign score was between 1 and 2 in groups III to VI and there was a significant difference (p<0.05) in the level of cholesterol and Alkaline Phosphatase (ALP) in the groups administered with the extract and the positive control (Group I) though there were no significant differences (p>0.05) in the level of Aspartate transaminase (AST). Low levels of serum ALP and Alanine transferase (ALT) were also observed in the groups administered with the various doses of the extract compared to the positive control. The study demonstrated the potency of Momordica balsamina extract against the avian paramyxovirus -1 in the experiment.

show abstract

“…The crude extract was prepared based on the method described by Garba et al (2018). Briefly, fifty grams of the dried stem bark sample was pulverised to powdered form and cold extracted in 400 ml of 70% v/v (methanol/water mixture ).…”

Section: Preparation Of the Extractmentioning

confidence: 99%

“…Some local Nigerian names of this plant include: Magimfa, jimfa or shibi in Hausa, lekki liddi in fulfulde, Koha or kuhwa in Tiv, orobeja in Yoruba, iwele in Igbo, oha in Idoma etc. (Garba et al, 2019). Many parts of the plants from this genus have been used traditionally for the treatment of diseases like rheumatic pains, syphilis, dropsy, stomach ache, diarrhoea, asthma, respiratory disorders, as well as being used as abortifacient, laxative diuretic, anti-inflammato r y agent, ,.etc (Dzenda et al, 2007;Qureshi et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

In vivo Trypanostatic Activity of Tephrosia linearis Extract on Trypanosoma evansi

Garba,

Ampitan,

AbdulAzeez

et al. 2021

Fountain Journal of Natural and Applied Sciences

View full text Add to dashboard Cite

In vivo antitrypanosomal activity of 70% methanol extract of Tephrosia linearis was evaluated. Mice infected with Trypanosoma evansi in different groups were administered 100, 200, 300 and 400 mg/kg body weight/day of the seventy percent (v/v) (methanol/water) crude extract of T. linearis intraperitoneally. The positive control group was treated with standard drug, berenil, while the negative control was infected and treated with normal saline. Doses of 300 and 400 mg/kg bw i.p. per day were found to significantly reduce the parasite loads and sustained the animals in the respective groups up to 3 and 4 weeks beyond the experimental period. There is drop in the percentage PCV during the first six days of the treatment but this was reversed in the subsequent days, except in the negative control group. The animals administered the highest effective (trypanostatic) dose of 400 mg/kg body weight for five consecutive days prior to infection were observed to develop infection 72 h post inoculation. The LD50 determined was found to be 2800 mg/kg bw. It is obvious that, higher doses of 300 and 400 mg/kg bw has trypanostatic effect. Though, the extract could not show any prophylactic activity, further purification may possibly yield a fraction with trypanocidal effect. Keywords: Tephrosia linearis, Methanol extract, Trypanosoma evansi, Antitrypanosomal activity, In vivo

show abstract

Hepato-protective potentials of Sterculia setigera stem-bark extract on acetominophen induced hepato toxicity in Wistar albino rats

Cited by 4 publications

References 17 publications

Ethnomedicinal study and in vitro validation of medicinal plants used for treating Jaundice in Zuru emirate of Kebbi State, Nigeria

Ethnomedicinal study and in vitro validation of medicinal plants used for treating Jaundice in Zuru emirate of Kebbi State, Nigeria

PROPHYLACTIC POTENCY OF METHANOLIC EXTRACT OF Momordica balsamina L. AGAINST AVIAN PARAMYXOVIRUS-1 INFECTION IN BROILER CHICKENS

In vivo Trypanostatic Activity of Tephrosia linearis Extract on Trypanosoma evansi

Contact Info

Product

Resources

About