Hepato-nephrotoxicity in late juvenile of Oreochromis niloticus exposed to gibberellic acid: Ameliorative effect of Spirulina platensis

Sayed, Alaa El‐Din H.; Abd-Allah, Elham A.; Hamed, Mohamed; Soliman, Hatem

doi:10.1016/j.pestbp.2020.104600

Cited by 16 publications

(13 citation statements)

References 25 publications

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“…Many organs exposed to GA3s have been shown to be negatively affected, including the liver, kidney, ovaries, pancreas, cerebellum, testes, and ovaries (Ali et al, 2018; Aty & Masoud, 2016; Lamfon, 2013; Sayed et al, 2020; Soliman et al, 2009; Soliman et al, 2021a; Soliman et al, 2021b). We investigated the negative effects of GA3 on the testes using biochemical, genetic, and histopathological methods and evaluated the potential protective role of chrysin.…”

Section: Discussionmentioning

confidence: 99%

“…GA3 treatment in rats decreased hepatic carbohydrates, total protein content, and liver biomarkers in the serum, as well as alkaline phosphatase (Hussein et al, 2011; Muthu et al, 2011). In the testes of rats, GA3 has been reported to cause DNA damage and oxidative stress (Sayed et al, 2020; Soliman et al, 2009; Soliman et al, 2021a; Soliman et al, 2021b). The use of GA3 for an extended period of time reduced antioxidant enzyme activity and elevated oxidative stress.…”

Section: Introductionmentioning

confidence: 99%

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Chrysin abrogates gibberellic acid‐induced testicular oxidative stress and dysfunction via the regulation of antioxidants and steroidogenesis‐ and apoptosis‐associated genes

Soliman

Aldhahrani

Ghamry

et al. 2022

Journal of Food Biochemistry

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GA3 is widely used as a growth stimulant in agricultural regions. The long‐term use of GA3 can cause organs damage. Chrysin is a flavonoid found in nature that is commonly used to treat organ toxicity. In this study, we examined the effect of chrysin on the testes function of GA3‐affected rats. A total of 24 male Wistar rats were divided into 4 groups. Saline was given to the control group. The chrysin group was given orally 50 mg/kg/BW of chrysin in saline. The GA3 group received a daily oral gavage of GA3 (55 mg/kg/BW). The protective group (chrysin + GA3) was given chrysin and GA3 as those described in chrysin and GA3 groups. There were an increase in MDA levels in the serum and testicular tissue of GA3‐treated group. Catalase, GSH, and SOD levels were all lowered in the GA3‐treated rats. Chrysin dramatically reduced the harmful effects of GA3 by restoring reproductive hormone levels, altered sperm parameters, and antioxidant capabilities. Furthermore, GA3 reduced the quantitative expression of steroidogenesis genes StAR and 3‐HSD, as well as Bcl2 genes, while it increased the apoptotic marker BAX; all were alleviated by the pre‐administration of chrysin. The pre‐administration of chrysin protected the GA3 group from spermatogenic vacuolation, interstitial edema, necrosis, and depletion. Chrysin inhibited oxidative stress and modulated antioxidant activity, as well as apoptosis‐/anti‐apoptosis‐related mediators in the testes. Chrysin has the potential to repair GA3‐induced testicular dysfunctions. This suggests that chrysin is preferable as a medication to mitigate GA3‐induced oxidative damage in the testes. Practical applications Chrysin has the potential to repair GA3‐induced testicular dysfunctions. This suggests that chrysin is preferable as a medication to mitigate GA3‐induced oxidative damage in the testes.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Chrysin abrogates gibberellic acid‐induced testicular oxidative stress and dysfunction via the regulation of antioxidants and steroidogenesis‐ and apoptosis‐associated genes

Soliman

Aldhahrani

Ghamry

et al. 2022

Journal of Food Biochemistry

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“…The hematotoxicity of GA 3 has been studied using animal models such as rats and mice (Tuluce and Çelik 2006;Muthu et al 2011;Troudi et al 2012a;Ali et al 2021Ali et al , 2022Ahmed and Nofal 2021;Galal et al 2021;Soliman et al 2021aSoliman et al , b, 2022aBushra and Shenouda 2022), hens and quail hens (Elsebai et al 2003b;Elkomy et al 2008;Ismail 2009), and rabbits (El-Sebai 2004). Nevertheless, the impacts of GA 3 on the hematological parameters and erythron profile of fish have not been investigated (Sayed et al 2020). In fish, direct contact between highly vascularized structures, such as gills and polluted water represents one of the main exposure routes for contaminants to enter the bloodstream (Barboza et al 2020).…”

Section: Introductionmentioning

confidence: 99%

“…Spirulina contains vital compounds, including protein (50-70% on dry mass basis) with all essential amino acids (Farag et al 2016), carotenoids, chlorophyll, pigments, essential fatty acids (alpha-linolenic, gamma-linolenic, and linoleic acid (Mendes et al 2003, Peiretti andGiorgia 2011), photosynthetic pigments (Bermejo et al 2008), vitamins (thiamine, nicotinamide, riboflavin, folic acid, pyridoxine, vitamins A, D, and E) (Hosseini et al 2013) and minerals (such as Ca, K, Cr, Cu, Mn, Fe, P, Mg, Na, Zn, and Se) (Babadzhanov et al 2004), making Spirulina an efficient feed supplement (Yousefi et al 2019). Nevertheless, the potential remediation effects of Spirulina against toxicity of phytohormones such as GA 3 have not been investigated, especially in fish of high economic importance (Sayed et al 2020).…”

Section: Introductionmentioning

confidence: 99%

The mitigating effect of Spirulina (Arthrospira platensis) on the hemotoxicity of gibberellic acid on juvenile tilapia (Oreochromis niloticus)

Sayed

Hamed

El-Sayed

et al. 2022

Environ Sci Pollut Res

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The use of plant growth regulators has led to environmental contamination of water bodies that occur adjacent to agricultural areas. Some of these chemicals are bioactive, not only to plants, but also to non-target exposed biota, namely of the aquatic compartment. Previous work demonstrated the establishment of hepato- and nephrotoxic effects in juvenile tilapia (Oreochromis niloticus) exposed via aquatic media to gibberellic acid (GA3), which is among the most used plant growth regulators, in agricultural practices. Here, we investigated the effect of GA3 on hematological indices, poikilocytosis, nuclear abnormalities, and genotoxic indices measured in Nile tilapia (Oreochromis niloticus), as well as the putative protective effects of dietary supplementation of Spirulina (Arthrospira platensis). Fish were evenly assorted into 5 groups: group I served as a control, and groups II–V were fed diets supplemented with Spirulina at rates of 0 g/kg, 5 g/kg, 20 g/kg, and 100 g/kg, respectively, for 2 months before being exposed to 150 mg/L GA3. The results revealed that GA3 exposure decreased significantly all hematological indices (P < 0.05), except leucocytes and mean corpuscular hemoglobin concentration (MCHC), compared to the control group (P > 0.05). GA3 exposure increased significantly the percentage of nuclear abnormalities, altered erythrocytes and the percentages of tail DNA, compared to the control group (P < 0.05). Spirulina supplementation restored the hematological, poikilocytosis, nuclear abnormalities, and the percentages of tail DNA to near normal levels. The 100 g/kg SP treatment was the most effective in attaining such effect, showing concentration-dependency. The present study reinforces our findings of the toxicity of GA3 on O. niloticus and suggests that the addition of Spirulina to fish diet can mitigate the hemotoxic effects of GA3.

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“…which is Tilapia, that constitutes about 43.5% of farmed fish production and 24% of the total fisheries production (GAFRD, 2007), and recently, it has been used as a model for toxicology in bioremediation studies (Sayed et al, 2020). Parasitic diseases account for 80% of fish diseases (Tayel et al, 2020).…”

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confidence: 99%

Ecological, Hematological and Parasitological Studies on Oreochromis niloticus Linnaeus 1757 in the Nile Delta Region, Egypt

Omar¹,

Hagras²,

El-Naggar³

et al. 2021

Egypt. J. of Aquatic Biolo. and Fish.

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Water pollution occurs when unwanted substances enter the water and affect water quality (Alrumman et al., 2016) that harm the environment and human health (Briggs, 2003). Such phenomenon is due to domestic and industrial wastewater leaping from water tank leaks, the ocean dumping of radioactive wastes and atmospheric deposition (Khan et al., 2013). In Egypt, 20% of the white animal protein production depends on fish. The most common farmed fish species is Oreochromis niloticus (Elgohary et al., 2020), among ARTICLE INFO

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Hepato-nephrotoxicity in late juvenile of Oreochromis niloticus exposed to gibberellic acid: Ameliorative effect of Spirulina platensis

Cited by 16 publications

References 25 publications

Chrysin abrogates gibberellic acid‐induced testicular oxidative stress and dysfunction via the regulation of antioxidants and steroidogenesis‐ and apoptosis‐associated genes

Chrysin abrogates gibberellic acid‐induced testicular oxidative stress and dysfunction via the regulation of antioxidants and steroidogenesis‐ and apoptosis‐associated genes

The mitigating effect of Spirulina (Arthrospira platensis) on the hemotoxicity of gibberellic acid on juvenile tilapia (Oreochromis niloticus)

Ecological, Hematological and Parasitological Studies on Oreochromis niloticus Linnaeus 1757 in the Nile Delta Region, Egypt

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