Hepatitis E Virus Infection as a Possible Cause of Acute Liver Failure in Europe

Abstract

In a hospital in Germany, approximately 10% to 15% of patients with ALF had evidence for HEV infection. Serologic tests for IgG against HEV are insufficient to identify or exclude HEV infection; tests for HEV RNA also should be performed on patients with ALF of ambiguous etiology.

A Rare Association between Left Lobe Secondary Biliary Cirrhosis and Budd-Chiari Syndrome Secondary to Hepatocellular Carcinoma in the Non-Cirrhotic Right Liver Lobe

“…Of the four human HEV-genotypes, in developed regions genotypes 3 and 4 are considered pathogenic, with zoonotic transmission, predominantly after ingestion of infected pork meat [5,7]. While HEV infection may be responsible for up to 40% of acute liver failure cases in endemic areas [8], in western countries its involvement has been proved in only 10-15% cases [9].…”

Acute Liver Failure in Adults: Etiology, Clinical Manifestations, Methods of Correction

“…Во мно-гих других регионах (не считающихся эндемич-ными) роль данного вируса в поражении печении, в том числе с развитием ОПН, по-видимому, пока еще не до конца оценена. Так, по данным литерату-ры, в странах Европы при расшифровке этиологии криптогенной ОПН у госпитализированных паци-ентов в 10% случаев был выявлен ВГЕ [36]. В некоторых азиатских, средиземноморских стра-нах и странах Европы наиболее частой причи-ной ОПН считается вирус гепатита В (ВГВ) [33].…”

Hepatic histological comparison between Acute Self-limiting Hepatitis A and Hepatitis E

“…On the other hand, AH-A and AH-E in industrialized countries including the USA, European countries and Japan are often seen even in older people, because the positive rate of serum anti-HAV immunoglobulin (Ig) G has decreased in older people; additionally, the positive rate of serum anti-HEV IgG has become extremely low in all age groups [7][8][9][10][11]. AH patients with HAV and HEV infection often progress to acute liver failure (ALF) [12][13][14][15]. In particular, sex, age, genotype and the existence of pregnancy in AH-E, and nucleotide variations in the 5' non-translated region of HAV RNA in AH-A have been closely associated with the progression of ALF, respectively [3,4,[8][9][10][11][12][13][14][15].…”

“…AH patients with HAV and HEV infection often progress to acute liver failure (ALF) [12][13][14][15]. In particular, sex, age, genotype and the existence of pregnancy in AH-E, and nucleotide variations in the 5' non-translated region of HAV RNA in AH-A have been closely associated with the progression of ALF, respectively [3,4,[8][9][10][11][12][13][14][15].…”