Hepatitis E virus antibody prevalence

Courtney, Michael; O'Mahoney, M.; Al-Bloushi, S.; Sachithanandan, Sharmila; Walshe, J.; Carmody, M.; Donoghue, J.Lloyd; Parfrey, Nollaig A.; Shattock, A. G.; Jf, Fielding

doi:10.1016/s0140-6736(94)90678-5

Cited by 20 publications

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“…A high prevalence of anti-HEV antibody was reportedly observed among hemodialysis patients, the majority of whom had a history of blood transfusions [11,20] . However, other investigators found only a few HEV antibody-positive patients in larger groups of hemodialysis patients [10,17,18] . In industrialized countries, the prevalence of positivity for HEV antibody in patients with hemophilia seems to differ between countries [12][13][14][15][16] , whereas a higher prevalence in patients with hemophilia than in volunteer blood donors has been reported in nonindustrialized countries [19] .…”

Section: Discussionmentioning

confidence: 91%

“…The parenteral route of HEV transmission, however, remains controversial; some studies have suggested parenteral transmission of HEV, but others have shown no parenteral transmission of this virus [9][10][11][12][13][14][15][16][17][18][19][20] . Patients with hemophilia are at high risk of infection by transfusion-transmissible viruses due to the frequent use of coagulation factors.…”

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confidence: 99%

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Prevalence of Hepatitis E Virus IgG Antibody in Japanese Patients with Hemophilia

Toyoda

Honda²,

Hayashi³

et al. 2008

Intervirology

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Objective: We investigated the prevalence of antibody against hepatitis E virus (HEV) in Japanese patients with hemophilia. Methods: IgG antibody against HEV was measured in serum of 80 Japanese patients with hemophilia by enzyme-linked immunosorbent assay. The prevalence of HEV antibody was compared with the reported prevalence of HEV antibody in Japanese patients undergoing hemodialysis and in Japanese healthy blood donors. Characteristics of patients and coinfection with other transfusion-transmissible viruses were compared in patients with and without HEV antibody. Results: Anti-HEV IgG antibody was detected in 13 of 80 patients (16.3%). The prevalence was far higher than that reported in Japanese blood donors (3.7%) and was higher than that in Japanese patients undergoing hemodialysis (9.4%). The patients with HEV antibody were significantly older than those without. HEV antibody was not detected in patients <20 years of age and in patients who had received only virus-inactivated coagulation factors. No association was observed between positivity for anti-HEV antibody and severity of hemophilia or coinfection with other parenterally transmissible viruses. Conclusion: Our results suggest that the parenteral transmission of HEV may have occurred in Japanese patients with hemophilia via non-virus-inactivated coagulation factors.

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Section: Discussionmentioning

confidence: 91%

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confidence: 99%

Prevalence of Hepatitis E Virus IgG Antibody in Japanese Patients with Hemophilia

Toyoda

Honda²,

Hayashi³

et al. 2008

Intervirology

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“…We thus acquired the con viction that hepatitis C transmission can be averted in haemodialysis by elementary hy giene measures. These are systematic disin fection of the dialysate delivery systems be tween sessions in different patients and sur face decontamination, use of single-pass di alysate delivery' systems, and isolation of se ronegative patients, this is probably also val id to avoid contamination by hepatitis E [ 16,17], as well as most other as yet identified viruses.…”

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confidence: 99%

Contamination by Hepatitis C in a Haemodialysis Center: Preventive Measures

Guiserix¹

1996

Nephron

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“…Başlıca bulaş yolu fekal oral yol olan HEV'nun kan transfüzyonu ile gönüllülere bulaştırılabilmiş olması parenteral bulaş ihtimalini desteklemektedir [35,36]. Sonuç olarak; kronik böbrek yetmezliği olan hemodiyaliz hastalarında anti-HEV IgG pozitifliğinin kontrol grubundan daha yüksek olması, en azından parenteral bulaş riskinin yüksek olduğu bu tür hasta gruplarında, tek bulaş yolunun fekal-oral yol olamayacağı ve parenteral bulaşın da olabileceğini düşündürmektedir [36,37].…”

Section: Discussionunclassified

The seroprevalance of hepatitis E, hepatitis G and TTV in haemodialysis patients

et al. 2017

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ÖzAmaç: Hemodiyaliz hastaları kan, kan ürünleri, perkütan yaralanma veya fekal-oral yolla bulaşabilen hepatit virüs-leri açısından risk grubunda yer alır. Bu çalışmada, hemodiyaliz hastalarında Hepatit E, Hepatit G ve TTV seropozitifliğinin belirlenmesi amaçlandı. Gereç ve Yöntemler:Çalışmaya 66 hemodiyaliz hastası (30 kadın, 36 erkek) ve 66 kontrol (43 kadın, 23 erkek) olmak üzere toplam 132 kişi dahil edildi. Çalışmada anti-HEV, anti HGV ve anti-TTV IgG düzeyleri ELISA yöntemi ile çalışıldı. İstatistiksel analizler SPSS programı ile yapıldı. Elde edilen sonuçların istatistiksel değerlendirilme-sinde Students t testi, Fischer exact testi ve Mann Whitney-U testleri kullanıldı. P < 0.05 değeri istatistiksel olarak anlamlı kabul edildi. Bulgular: Çalışmaya alınan 66 hasta ve 66 sağlıklı kontrol grubunun yaş ortalaması sırasıyla; 54,9 ve 47,2 idi. Hasta ve kontrol grubunun yaş ortalaması karşılaştırıldığında hasta grubunun yaş ortalaması daha yüksekti.Anti-TTV IgG ve anti-HEV IgG pozitifliği hemodiyaliz hastalarında kontrol grubuna göre daha yüksek bulundu. Hasta ve kontrol grubunda anti-HGV IgG pozitifliği tespit edilmedi. Hemodiyaliz hasta grubunda anti-TTV IgG ve anti-HEV IgG pozitifliği ile hemodiyaliz süresi, yaş ve cinsiyet arasında istatistiksel olarak anlamlı bir ilişki saptanmadı.Sonuç: Hemodiyaliz hastaları, TTV, hepatit E virüsü ve diğer hepatit virüslerinin bulaşı açısından yüksek risk taşırlar. Bu nedenle, hemodiyaliz ünitelerde temizlik ve dezenfeksiyon kurallarına uyulması HEV ve TTV gibi hepatit virüslerinin bulaşını önlemek için gereklidir.

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Hepatitis E virus antibody prevalence

Cited by 20 publications

References 0 publications

Prevalence of Hepatitis E Virus IgG Antibody in Japanese Patients with Hemophilia

Prevalence of Hepatitis E Virus IgG Antibody in Japanese Patients with Hemophilia

Contamination by Hepatitis C in a Haemodialysis Center: Preventive Measures

The seroprevalance of hepatitis E, hepatitis G and TTV in haemodialysis patients

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