Prevalence of Hepatitis E Virus IgG Antibody in Japanese Patients with Hemophilia

Toyoda, Hidenori; Honda, Takashi; Hayashi, Kazuhiko; Katano, Yoshiaki; Goto, Hidemi; Kumada, Takashi; Takahashi, Kazuaki; Abe, Natsumi; Mishiro, Shunji; Takamatsu, Junki

doi:10.1159/000118792

Cited by 24 publications

(20 citation statements)

References 78 publications

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“…In addition, unexpectedly high anti-HEV immunoglobulin G (IgG) seroprevalence among the general population has been reported from some industrialized countries, although the rates varied considerably between reports, ranging from 2 . 3 to 33 % [3][4][5][6][7][8][9].…”

Section: Introductionmentioning

confidence: 99%

Transmission routes and risk factors for autochthonous hepatitis E virus infection in Europe: a systematic review

2009

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SUMMARYIncreasing numbers of non-travel-associated hepatitis E virus (HEV) infections have been reported in Europe in recent years. Our objective was to review the evidence on risk factors and transmission routes of autochthonous HEV infection and hepatitis E in Europe in order to develop recommendations for future research, prevention and control. A systematic literature review was performed to identify all primary reports and studies published during 1998-2008 on hepatitis E in humans and animals in Europe by searching Pubmed, reference lists of major articles and international conference proceedings. Each of the 106 included studies was categorized into one of three evidence levels (EL) based on study design and diagnostic methodology. The evidence was generally weak (73 were assigned to EL1, two to both EL1 and EL2, and 30 to EL2), further compounded by the use of poorly validated serological assays in some studies. Only one casecontrol study was assigned to EL3. Persons with autochthonous hepatitis E infection were on average older than the general population and predominantly male. There was no evidence for one main transmission route of HEV infection or risk factor for hepatitis E. However, zoonotic transmission seemed likely and person-to-person transmission too inefficient to cause clinical disease. Multiple routes of transmission probably exist and should be further investigated through analytical studies and reliable diagnostic kits. Based on current evidence that points to zoonotic transmission from pigs, thorough cooking of all porcine products, prevention of crosscontamination in the kitchen and improved education for occupationally exposed people (e.g. pig farmers, veterinarians and sewage workers) may help prevent HEV infection. Although evidence for parenteral transmission is limited, it is recommended that a risk assessment is undertaken.

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Section: Introductionmentioning

confidence: 99%

Transmission routes and risk factors for autochthonous hepatitis E virus infection in Europe: a systematic review

2009

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“…Toyoda et al reported 16.3% HEV seropositivity among hemophilia patients. They also suggested that the parenteral transmission of HEV may have occurred in Japanese patients with hemophilia via non-virus-inactivated coagulation factors (34). Other studies in different countries showed lower HEV seropositivity among hemophilia patients (45)(46)(47)(48) than Japan.…”

Section: Discussionmentioning

confidence: 98%

“…On the other hand, some effective examinations such as blood-donor screening, viral inactivation of plasma-derived products, and development of recombinant clotting factors are used to reduce viral exposure (31). Several studies that were done in Japan reported high prevalence of HAV and HEV infection among hemophilia patients compare to healthy individual (control group) (33,34).…”

Section: Discussionmentioning

confidence: 99%

The Seroprevalence of Entrically Transmitted Viral Hepatitis in HCV Infected Thalassemia and Hemophilia Patients in Iran

Elizee

Alavian

Miri

et al. 2013

Jundishapur J Microbiol

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Background: Hepatitis A and E virus (HAV and HEV) infections are acute and self-limited diseases that usually spread through oral-fecal route. Also, blood transfusion as a possible route of entrically transmitted hepatitis has been suggested. Hemophilia and thalassemia patients are highly at risk of transfusion-transmissible viruses (HBV, HCV, and HIV). Any superimposed infection with other viral hepatitis (in particular hepatitis A) cause active liver failure in hemophilia and thalassemia patients. Objectives: The aim of this study is to consider seroprevalence of anti HAV and HEV antibodies (Ab) in thalassemia and hemophilia patients with chronic hepatitis C in Iran. Patients and Methods:In a cross-sectional study and under general census sampling, sera of 219 thalassemia and hemophilia patients infected with HCV were examined in Tehran Hepatitis Center (THC) between 2009 and 2010. Enzyme-linked immunisorbentassey (ELISA) was done to observe anti HAV and HEV IgG Ab. Patients were chosen from all provinces of Iran. Results: Anti-HAV IgG antibodies were observed more frequently in thalassemia patients (60/64; 93.8%) than in hemophilia patients (104/155; 67.1%, P < 0.001). The seroprevalence of both antibodies increased with age. Among thalassemia patients, there was no significant association between HAV seropositivity and other variables, but in hemophilia group, seropositive patients were significantly older than seronegative group (P < 0.05). Totally, anti HEV Ab (1/64; 1.6% thalassemia and 5/155; 3.2% hemophilia) was seropositive in six patients. There was no significant association between HEV infection and other variables in thalassemia patients, however, in hemophilia patients, HEV positive ones were significantly older than HEV negative group (P=0.01). Conclusions: Vaccination of non-immune individuals against HAV infection in high risk groups especially hemophilia and thalassemia patients is recommended. Results did not show any differences about seroprevalence of HEV among Iranian general population.

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“…In der Literatur sind nur wenige Untersuchungen von Hämophiliepatienten berichtet worden [196,197]; in keiner dieser Untersuchungen gab es Hinweise auf ein erkennbares HEV-Infektionsrisiko durch Gerinnungspräparate. Allerdings wurde in einer japanischen Studie bei äl-teren Hämophiliepatienten, die auch mit nicht virusinaktivierten Gerinnungsprä-paraten behandelt worden waren, eine erhöhte Antikörperprävalenz festgestellt [198]. Des Weiteren wurde kürz-lich aus Kanada und Frankreich berichtet, dass HEV durch SD-Plasma übertra-gen werden kann [199,200].…”

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Hepatitis-E-Virus

Gesundheit¹

2015

Bundesgesundheitsbl.

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Prevalence of Hepatitis E Virus IgG Antibody in Japanese Patients with Hemophilia

Cited by 24 publications

References 78 publications

Transmission routes and risk factors for autochthonous hepatitis E virus infection in Europe: a systematic review

Transmission routes and risk factors for autochthonous hepatitis E virus infection in Europe: a systematic review

The Seroprevalence of Entrically Transmitted Viral Hepatitis in HCV Infected Thalassemia and Hemophilia Patients in Iran

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