Hepatitis E in decompensated alcoholic cirrhosis

Renou, Christophe; Lesgourgues, Bruno; Macaigne, Gilles; Pauwels, Arnaud; Bricquir, Y. Le; Henrion, Jean; Khemissa, Faïza; Clair, E. William St.; Paupard, Thierry; Pélaquier, A.; Agostini, Hélène; Roque–Afonso, Anne–Marie

doi:10.1002/hep.28792

Cited by 3 publications

(3 citation statements)

References 2 publications

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“…This can cause high mortality, estimated to be 21%, or premature delivery and infant mortality particularly when infections occur in the third trimester of pregnancy (Jin et al, 2016). In EU/EEA countries where HEV-3 is prevalent, the infection is not associated with severe disease in pregnant women and thus they are not considered as a risk group (Anty et al, 2012;S anchez D ıaz et al, 2012;Renou et al, 2013Renou et al, , 2014bTabatabai et al, 2014).…”

Section: Chronic He and Hev In Immune-compromised And Pregnant Patientsmentioning

confidence: 99%

Public health risks associated with hepatitis E virus (HEV) as a food‐borne pathogen

Ricci¹,

Allende²,

Bolton³

et al. 2017

EFS2

111

107

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Hepatitis E virus (HEV) is an important infection in humans in EU/EEA countries, and over the last 10 years more than 21,000 acute clinical cases with 28 fatalities have been notified with an overall 10-fold increase in reported HEV cases; the majority (80%) of cases were reported from France, Germany and the UK. However, as infection in humans is not notifiable in all Member States, and surveillance differs between countries, the number of reported cases is not comparable and the true number of cases would probably be higher. Food-borne transmission of HEV appears to be a major route in Europe; pigs and wild boars are the main source of HEV. Outbreaks and sporadic cases have been identified in immune-competent persons as well as in recognised risk groups such as those with preexisting liver damage, immunosuppressive illness or receiving immunosuppressive treatments. The opinion reviews current methods for the detection, identification, characterisation and tracing of HEV in food-producing animals and foods, reviews literature on HEV reservoirs and food-borne pathways, examines information on the epidemiology of HEV and its occurrence and persistence in foods, and investigates possible control measures along the food chain. Presently, the only efficient control option for HEV infection from consumption of meat, liver and products derived from animal reservoirs is sufficient heat treatment. The development of validated quantitative and qualitative detection methods, including infectivity assays and consensus molecular typing protocols, is required for the development of quantitative microbial risk assessments and efficient control measures. More research on the epidemiology and control of HEV in pig herds is required in order to minimise the proportion of pigs that remain viraemic or carry high levels of virus in intestinal contents at the time of slaughter. Consumption of raw pig, wild boar and deer meat products should be avoided.

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Section: Chronic He and Hev In Immune-compromised And Pregnant Patientsmentioning

confidence: 99%

Public health risks associated with hepatitis E virus (HEV) as a food‐borne pathogen

Ricci¹,

Allende²,

Bolton³

et al. 2017

EFS2

111

107

View full text Add to dashboard Cite

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“…3,4 Nonetheless, two recent studies reported low rates of acute HEV infection in American patients with acute liver failure (0.4%) and French patients admitted for decompensation of alcoholic CLD (0.2%). 5,6 In contrast, we observed in 2016 in that found markers of acute HEV infection in 3/84 patients (4%) admitted for acute alcoholic hepatitis. 8 Besides, one should have in mind that acute HEV infection is common in France as shown by the prevalence rates of IgM and HEV RNA among blood donors, which are 1% and 0.4&, respectively, at the country scale, and 3.2%-4.6% and 0.7%-0.9&, respectively, in southern France.…”

Section: Letter: Liver Transplantation For Acute Hev Infection In Cirmentioning

confidence: 67%

Letter: liver transplantation for acute HEV infection in cirrhotic patients in France

Borentain¹,

Colson

Grégoire

et al. 2017

Aliment Pharmacol Ther

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“…In our prospective series of a large IBD population treated with immunosuppressive drugs, no acute viremic HEV infections were found, and HEV did not account for unexplained liver enzyme elevations or DILI. Similarly, HEV infection was not found to contribute significantly to the hepatic decompensation among 181 consecutive cirrhosis patients [ 22 ]. However, case reports have been published on HEV as a cause of cirrhotic decompensation [ 23 ], but it might be too infrequent to be detected in a prospective series.…”

Section: Discussionmentioning

confidence: 99%

Hepatitis E Virus Infection in Patients with Chronic Inflammatory Bowel Disease Treated with Immunosuppressive Therapy

Kounis

Renou²,

Nahon

et al. 2023

Pathogens

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Background: Medical treatment of inflammatory bowel disease (IBD) has evolved significantly, and treatment with immunomodulators is recommended. These medications may alter the patient’s immune response and increase the risk of opportunistic infections. Our aim was to evaluate the prevalence and the incidence of acute or chronic HEV infection in IBD patients under immunomodulatory treatment. Patients and Methods: We conducted a retrospective, multicenter, observational study between 2017 and 2018. IBD outpatients hospitalized for the infusion of immunomodulators were included in 16 French centers. During their daily hospitalization, blood samples were drawn for HEV serology (IgM and IgG) and HEV RNA detection. Results: A total of 488 patients were included, of which 327 (67%) patients had Crohn’s disease and 161 (33%) ulcerative colitis. HEV IgM was detected in 3 patients, but HEV RNA was undetectable in all patients. The HEV IgG seroprevalence rate was 14.2%. IgG-positive patients were older at sampling (p = 0.01) and IBD diagnosis (p = 0.03), had higher seafood consumption (p = 0.01) and higher doses of azathioprine (p = 0.03). Ileal and upper digestive tract involvement was more frequent in IgG-positive patients (p = 0.009), and ileocolic involvement was more frequent in IgG-negative patients (p = 0.01). Under multivariate analysis, age > 50 years [OR: 2.21 (1.26, to 3.85), p = 0.004] was associated with previous HEV infection. Conclusion: Systematic screening for HEV infection is not needed among IBD patients on immunomodulatory medications. However, in the event of abnormal liver test findings, HEV should be part of the classic diagnostic assessment.

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Hepatitis E in decompensated alcoholic cirrhosis

Cited by 3 publications

References 2 publications

Public health risks associated with hepatitis E virus (HEV) as a food‐borne pathogen

Public health risks associated with hepatitis E virus (HEV) as a food‐borne pathogen

Letter: liver transplantation for acute HEV infection in cirrhotic patients in France

Hepatitis E Virus Infection in Patients with Chronic Inflammatory Bowel Disease Treated with Immunosuppressive Therapy

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