Hepatitis C virus infection in HIV-infected men in Singapore, 2006–2018: incidence and associated factors

Abstract

Background: The epidemiology of hepatitis C virus (HCV) infection in people living with HIV has been evolving, with increasing evidence of permucosal (sexual) transmission identified predominantly in HIV-positive men who have sex with men (MSM). The aim of this study was to estimate the incidence rate and elucidate epidemiological factors associated with HCV infection among HIV-infected men in Singapore from 2006 to 2018. Methods: A retrospective cohort study was conducted using a clinical database maintained by the Clinical HIV Program at the National Centre for Infectious Diseases, Singapore. Factors associated with incident HCV infections were identified using Cox proportional hazards regression analyses. Results: Among 1348 HIV-infected male patients who were HCV seronegative at baseline, 64 (4.7%) subsequently tested positive for HCV, giving an incidence of 0.88 per 100 personyears of follow-up (PYFU) (95% confidence interval (CI) 0.69-1.13). The incidence rate of HCV seroconversion increased from 0.33 (95% CI 0.12-0.71) per 100

Incidence of hepatitis C virus infection among people living with HIV: An Egyptian cohort study

“…The incidence rates of HIV/HCV co-infection in some Asian and European countries were lower than that reported in this study with a rate of 0.88 per 100 person-years in Singapore, 19 and 0.72 and 0.44 per 100 person-years among MSM in France 20 and Italy 21 . A systematic review conducted between 2000 and 2016 reported an incidence rate of 0.78 per 100 person-years among MSM.…”

Trends in hepatitis C virus coinfection and its cascade of care among adults living with HIV in Asia between 2010 and 2020

“…In the Asia-Pacific region, the prevalence of HCV co-infection among adult PLHIV ranges from 2.9% to 80% depending on the characteristics of the study population [4][5][6][7][8][9][10][11][12]. Injecting drug use is consistently associated with an increased risk of HCV coinfection, [10,[13][14][15][16] and men who have sex with men (MSM) and sex workers living with HIV are also at increased risk [17,18]. Other factors associated with HCV coinfection among Asian adult PLHIV include older age, lower education [19], lower CD4 cell count [4,20], and having a household member with liver disease [21].…”