Hepatitis C virus, directly acting antivirals and Guillain-Barré syndrome

Background: Chronic kidney disease associated pruritus (CKD-ap) and xerosis is intensely annoying and unpleasant manifestations associated with maintenance renal dialysis (MRD) among chronic kidney disease (CKD) patients. It severely compromises the quality of life by disturbing normal sleep pattern and also adversely affect the mental health in CKD patients. Many proposed treatment plan for CKD –ap is tested but none of the treatment plan provide complete relief from itch associated with MRD. Glycerine accelerate barrier repair and also has rapid hydrating and smoothing effect while Paraffin preserve the barrier function against irritant. As a comparator Mustard oil is used as it is commonly used home remedy by people in Indian sub-continent for dry skin. Objectives: The primary objective of the study is to compare the efficacy of Glycerine –paraffin combination with mustered oil on skin related quality of life among CKD patients with CKD-ap and xerosis. Methodology: A randomised, single blind, controlled, clinical trial intending to investigate and compare the efficacy of Glycerine – Paraffin combination with mustard oil in CKD –ap and xerosis and overall SRQOL among CKD patients. The study aims to enrol 140 CKD patients having moderate to severe CKD-ap and xerosis by using GI gammal score (standardized tool for assessment of xerosis). They will be randomly distributed among 2 parallel group, experimental & control group. Allocation concealment will be maintained by using SNOSE technique. Experimental group will be instructed to apply glycerine paraffin combination and mustard oil to control group twice a day for 4 weeks. participant will be evaluated for xerosis and pruritus score at baseline, day 7, day 28 and day 56. Scores of SRQOL will be assessed at baseline and on 56 days. Conclusion: The RCT aims to identify & compare the efficacy of Glycerine –paraffin combination with mustard oil on skin related quality of life among CKD patients with CKD-ap and xerosis.

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“…Studies on various aspects of chronic renal diseases were reported [19][20][21][22][23]. Studies from Global Injury were reviewed [24,25].…”

Section: Resultsmentioning

confidence: 99%

Topical Application of Glycerine – Paraffin Combination in CKD-associated Pruritus and Uremic Xerosis: Study Protocol for a Randomized Control Trial

Verma

Yeola

Ankar

2021

JPRI

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“…It may help in delaying aging process in individuals also. A number of studies on different liver conditions [23][24][25][26] and kidney diseases [27][28][29][30] were reviewed. Khan et al reported a study on Evaluation of In Vitro Anti-Cancer Activity of Kukkutanakhi Guggula on Liver, Prostrate, Ovary and Renal Cancer [31].…”

Section: Discussionmentioning

confidence: 99%

Research Protocol for Assessment of Solitary and Combined effect of Guduchi and Punarnava on Structural and Functional Changes of Ageing in Liver and Kidney in Wistar Rats

Tawalare

Dandekar

Desai

et al. 2021

JPRI

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Background: The liver and kidney play a central role in metabolic and detoxification processes leads to structural degeneration of organs with aging, which may hamper the functional ability of these organs. Acharya charaka suggests to use drugs of vayasthapana mahakashaya in different combinations to prevent ageing. Guduchi (Tinospora cardifolia) and punarnava (Boerhavia diffusa) are two drugs chosen to evaluate the solitary and combined effect on structural and functional changes in liver and kidney of Wistar rat. Materials and Methods: After identification and phytochemical study of test drugs, the 32 healthy, male rats of 18 months will be divided into four different groups, with eight rats in each group. 1st to 4th group will receive distilled water, guduchi kwath, punarnava kwath, guduchi and punarnava kwath respectively for 30 consecutive days at the rate of 8.1ml/kg dose, orally. Before administration of control drug and test drug blood sample assessment will be done for LFT, KFT, and SOD level. The same investigation will be repeated after one month trial period. Then after 60 days,120 days and 180 days, two animals from each group will be sacrificed, organs such as liver and kidney will be extracted and preserved for histopathological study, and blood samples will be collected for investigation. The remaining animals will be returned to the animal house for their reuse. Expected Results: Guduchi and punarnava may provide strength to liver and kidney and thus helpful in delaying degenerative changes of organs.

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“…Vision 2015 of MCI emphasizes on 'Competency-based learning' and insists for assessment of newer learning experiences, competencies, along with certification of essential skills 11 . Due attention is needed on patient specific systemic conditions like diabetes [12][13][14][15][16][17] , hypertension [18][19][20][21][22][23][24][25][26] , respiratory and renal disorders [27][28][29][30][31][32][33] .…”

Section: Discussionmentioning

confidence: 99%

Outcome of Infero Temporal Suture Less and Glue Free Conjunctival Autograft in Patients with Pterygium at a Tertiary Care Hospital of Vidarbha Region

2020

IJFMT

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Introduction: Pterygium is a common degenerative condition of the conjunctiva specially in the dry and arid climate. There are numerous treatment options for pterygium. Gluefree & Sutureless conjunctival autografting is one of the popular method to reduce its (Pterygium) recurrence.Purpose: To study outcome of inferior temporal conjunctival autografting which is sutureless & gluefree in Pterygium patients. Material and Method:A Prospective study was carried out on 104 out of 123 patients, which met Inclusion criteria. Pterygium surgery procedure include, pterygium excision followed by inferior conjunctival autografting without any glue and suture. The patients were followed up post-operatively on day 1, 1 week, 15 days, 1 month, 2 months. They all were examined for complications such as graft displacement, recurrence, haemorrhage along with routine post-operative examination. Results:The age of Patients varied between 21 to 70 years. 62.50 % of which were Male. Common age group in our study was 41-50 years. Redness & watering was most common symptoms in our study. Recurrence was seen 09 patients & graft displacement was seen in 7 patients. Recurrence was most commonly seen in patients having grade 3 Pterygium. Conclusion:Pterygium excision followed by inferior conjunctival grafting has an advantage of leaving the superior conjunctiva (commonly used in conjunctival autografting procedure) for glaucoma or cataract surgery if need arises . its also economical in context to our Country. The study aims at exploring options to improve the quality of life in cosmetically and visually challenged patients

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Hepatitis C virus, directly acting antivirals and Guillain-Barré syndrome

Cited by 9 publications

References 0 publications

Topical Application of Glycerine – Paraffin Combination in CKD-associated Pruritus and Uremic Xerosis: Study Protocol for a Randomized Control Trial

Topical Application of Glycerine – Paraffin Combination in CKD-associated Pruritus and Uremic Xerosis: Study Protocol for a Randomized Control Trial

Research Protocol for Assessment of Solitary and Combined effect of Guduchi and Punarnava on Structural and Functional Changes of Ageing in Liver and Kidney in Wistar Rats

Outcome of Infero Temporal Suture Less and Glue Free Conjunctival Autograft in Patients with Pterygium at a Tertiary Care Hospital of Vidarbha Region

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