Hepatitis C virus core protein induces hepatic steatosis via Sirt1‐dependent pathway

Abstract

Sirt1 mediates hepatitis C virus core protein 1b-induced hepatic steatosis by regulation of PPARγ2 expression.

Hepatitis B virus infection and risk of non‐alcoholic fatty liver disease: A population‐based cohort study

“…The impact of HCV on the development of NAFLD is well established, however, the underlying mechanism by which HBV mediates hepatic steatosis has not been clearly studied. Currently, studies have shown that the risk of NAFLD was significantly lower in HBV‐infected patients than in uninfected controls .…”

Obeticholic acid ameliorates obesity and hepatic steatosis by activating brown fat

“…Properly sized tissues were embedded in OCT compound, frozen at -80˚C and prepared for cryosectioning (Sakura Finetek USA, Inc.), and the thickness of the sections was maintained at 12-15 µm. Oil Red O staining was performed using a previously described method ( 20 ). The stained sections would be kept in 4˚C.…”

Allicin Regulates Energy Homeostasis through Brown Adipose Tissue

“…Therefore, increasing BAT activation and inducing beiging in WAT could be an effective therapeutic strategy for obesity and related diseases. SIRT1, a nuclear NAD + -dependent protein deacetylase (Landry et al, 2000) that belongs to the sirtuin family (referred to as Sirt1 to Sirt7) (Frye, 2000), plays a vital role in regulating transcription in various key metabolites (Zhang et al, 2018). Many studies have reported that SIRT1 can enhance BAT function and regulate metabolism (Xu et al, 2013;Boutant et al, 2015;Chalkiadaki and Guarente, 2012).…”