Allicin Regulates Energy Homeostasis through Brown Adipose Tissue

Zhang, Chuanhai; He, Xiaoyun; Sheng, Yao; Xu, Jia; Yang, Chao; Zheng, Shujuan; Liu, Junyu; Li, Haoyu; Ge, Jianbing; Yang, Mei; Zhai, Baiqiang; Xu, Wentao; Luo, Yunbo; Huang, Kunlun

doi:10.1016/j.isci.2020.101113

Cited by 30 publications

(30 citation statements)

References 55 publications

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“…In present study, we employed aqueous allicin-rich garlic extract (ARGE), prepared according to a previously reported method with slight modifi cations [33]. Allicin has multiple pharmacological functions, including cholesterol-lowering eff ects [34], browning of WAT [35] and regulates energy homeostasis through BAT activation [19]. Since allicin is a highly reactive volatile compound, it decomposes rapidly in the presence of air.…”

Section: Discussionmentioning

confidence: 99%

“…Allicin, one of the bioactive components of garlic has numerous biological functions including anti-obesity eff ects. Allicin administration enhances beiging/ browning of white adipose tissue, modulates gut microbiota and recently has been found to enhance whole-body energy metabolism via brown adipose tissue (BAT) activation [18,19]. Allicin is absent in the raw garlic and is only produced upon crushing of the garlic clove from its odorless precursor alliin through the enzymatic reaction of enzyme alliinase [20].…”

Section: Introductionmentioning

confidence: 99%

“…Aqueous extract of garlic, however, if stored at lower temperature, has stable allicin [22]. Recently, it has been shown that higher doses of allicin (500 μM) induce autophagy and mitophagy in cultured BAT adipocytes and excessive garlic intake could impair BAT functions [19]. Earlier studies suggested protective effects of allicin in high-fat diet-induced complications at relatively higher doses such as 50, 100 and 200 mg/ kg/day [23] and 100 mg/kg/day [18], therefore we tried to evaluate the preventive eff ects of allicin-rich garlic extract at lower dose (~ 2 mg/kg/day) in present study.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Allicin-rich garlic extract alleviates high-fat diet-induced complications in rats: A nutrigenomic study

Mahajan¹,

Kumar²,

Maurya³

et al. 2021

Hrana i ishrana

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The remedial effects of garlic in various metabolic complications have been attributed to a variety of organosulfur compounds such as allicin, diallyl sulfides, alliin and allyl trisulfides. The present study was designed to prepare an aqueous extract of garlic with stable allicin and its biological evaluation on tissue-specific nutrigenomic effects in the prevention of High-fat diet (HFD)-induced weight gain and related complications in Sprague-Dawley (SD) rats. Aqueous Allicin-rich garlic extract (ARGE) was prepared and characterized for stability of allicin using HPLC. For biological evaluation, animals were fed with either normal pellet diet (NPD), HFD, HFD along with ARGE (1ml/kg p.o.) and ARGE per se (1ml/kg p.o.) for 16 weeks. Chronic administration of ARGE prevented HFD-induced weight gain, adipose tissue hypertrophy, insulin resistance and improved overall glucose homeostasis. Transcriptional analysis of different tissues highlighted that ARGE promoted browning, improved glucose metabolism and appetite regulation. Overall, this study presents ARGE as a potential nutraceutical for the prevention of obesity and related comorbidities.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Allicin-rich garlic extract alleviates high-fat diet-induced complications in rats: A nutrigenomic study

Mahajan¹,

Kumar²,

Maurya³

et al. 2021

Hrana i ishrana

View full text Add to dashboard Cite

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“…Recently, it has been demonstrated that allicin administration to the HFD fed and Db/Db mice significantly increased BAT activity and energy expenditure. In-vitro experiments performed on isolated brown adipose tissues from mice showed that allicin directly activates BAT by upregulating the expression of UCP1 protein(C. Zhang et al, 2020). Cumulatively, these studies suggested the direct effect of TRPA1 agonists for the prevention of obesity by enhancing energy expenditure.…”

Section: Trpa1 In Bat Thermogenesis and Modulationmentioning

confidence: 99%

TRPA1 in obesity and insulin resistance

Mahajan

Khare

Kondepudi

et al. 2020

Preprint

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Transient receptor potential ankyrin 1 (TRPA1) channel is a calcium permeable, non-selective cation channel, expressed in the sensory neurons and non-neuronal cells of different tissues. Initially studied for its role in pain and inflammation, TRPA1 has now functionally involved in multiple other physiological functions. TRPA1 channel has been extensively studied for modulation by pungent compounds present in the spices and herbs. In the last decade, the role of TRPA1 agonism in body weight reduction, secretion of hunger and satiety hormones, insulin secretion and thermogenesis, has unveiled the potential of the TRPA1 channel to be used as a preventive target to tackle obesity and associated comorbidities including insulin resistance in type 2 diabetes. In this review, we summarized the recent findings of TRPA1 based dietary/non-dietary modulation for its role in obesity prevention and therapeutics.

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“…Purple maize extract rich in ferulic acid and anthocyans was found to prevent HFD-induced obesity in mouse models by promoting white fat browning and thermogenesis, while reducing inflammation, partly through upregulation of SIRT1 and AMPK [ 338 ]. Another compound, allicin, regulates energy homeostasis partly through SIRT1/PGC1α; however, at higher concentrations, it leads to mitochondrial problems through SIRT5 inhibition [ 535 ]. The compound 23-epi-25-deoxyactein was found to promote adipocyte lipolysis through AMPK signaling and the SIRT1/FOXO1 pathway, and to reduce body weight gain and fat mass [ 536 ].…”

Section: The Role Of Sirtuins In Metabolic Tissuesmentioning

confidence: 99%

Sirtuins-Mediated System-Level Regulation of Mammalian Tissues at the Interface between Metabolism and Cell Cycle: A Systematic Review

Maissan

Mooij

Barberis

2021

Biology

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Sirtuins are a family of highly conserved NAD+-dependent proteins and this dependency links Sirtuins directly to metabolism. Sirtuins’ activity has been shown to extend the lifespan of several organisms and mainly through the post-translational modification of their many target proteins, with deacetylation being the most common modification. The seven mammalian Sirtuins, SIRT1 through SIRT7, have been implicated in regulating physiological responses to metabolism and stress by acting as nutrient sensors, linking environmental and nutrient signals to mammalian metabolic homeostasis. Furthermore, mammalian Sirtuins have been implicated in playing major roles in mammalian pathophysiological conditions such as inflammation, obesity and cancer. Mammalian Sirtuins are expressed heterogeneously among different organs and tissues, and the same holds true for their substrates. Thus, the function of mammalian Sirtuins together with their substrates is expected to vary among tissues. Any therapy depending on Sirtuins could therefore have different local as well as systemic effects. Here, an introduction to processes relevant for the actions of Sirtuins, such as metabolism and cell cycle, will be followed by reasoning on the system-level function of Sirtuins and their substrates in different mammalian tissues. Their involvement in the healthy metabolism and metabolic disorders will be reviewed and critically discussed.

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Allicin Regulates Energy Homeostasis through Brown Adipose Tissue

Cited by 30 publications

References 55 publications

Allicin-rich garlic extract alleviates high-fat diet-induced complications in rats: A nutrigenomic study

Allicin-rich garlic extract alleviates high-fat diet-induced complications in rats: A nutrigenomic study

TRPA1 in obesity and insulin resistance

Sirtuins-Mediated System-Level Regulation of Mammalian Tissues at the Interface between Metabolism and Cell Cycle: A Systematic Review

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