Hepatitis C virus: a silent killer relevant to dentistry

Carrozzo, Marco

doi:10.1111/odi.12240

Cited by 5 publications

(3 citation statements)

References 60 publications

(64 reference statements)

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“…Research has demonstrated a strong association between HCV infection and OLP, which is explained by the ability of the virus to replicate in oral mucosa cells and attract HCV-specific T lymphocytes [ 28 ]. Furthermore, HCV is an oncogenic virus and might be involved in oral carcinogenesis [ 29 ].…”

Section: Discussionmentioning

confidence: 99%

Malignant transformation of oral lichen planus: a retrospective study of 565 Japanese patients

et al. 2021

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Background Oral lichen planus (OLP) is a chronic inflammatory oral mucosa disease that is recognized as an oral potentially malignant disorder. However, the potentially malignant nature of OLP remains unclear. Methods We designed this study to examine the demographic and clinical characteristics of patients with OLP and evaluate the associated malignant transformation rate. A total of 565 patients with a clinical and histopathological diagnosis of OLP who presented at our department between 2001 and 2017 were retrospectively studied. Patients who had clinical and histopathological features of oral lichenoid lesions (OLLs) classified as oral lichenoid contact lesions, oral lichenoid drug reactions and oral lichenoid lesions of graft-versus-host disease were excluded. Results The study population included 123 men and 442 women aged 21–93 years (mean ± standard deviation, 60.5 ± 11.8). The 565 patients were followed up for a duration of 55.9 ± 45.3 months, during which 4 (0.7%) patients developed squamous cell carcinoma (SCC). In three of these 4 patients who developed SCC, the clinical type of OLP was the red type. Conclusions Our results suggested that OLP was associated with a low risk of malignant transformation. We recommend regular follow-up for OLP patients and clear differentiation of oral epithelial dysplasia and OLLs to enable early detection of malignant transformation. Further investigation of the clinical risk factors associated with malignant transformation is necessary.

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Section: Discussionmentioning

confidence: 99%

Malignant transformation of oral lichen planus: a retrospective study of 565 Japanese patients

et al. 2021

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“…Research has demonstrated a strong association between HCV infection and OLP, which is explained by the ability of the virus to replicate in oral mucosa cells and attract HCV-speci c T lymphocytes [19]. Furthermore, HCV is an oncogenic virus and might be involved in oral carcinogenesis [20].…”

Section: Discussionmentioning

confidence: 99%

Malignant Transformation of Oral Lichen Planus: A Retrospective Study of 565 Japanese Patients

Tsushima

Sakurai

Uesugi

et al. 2021

Preprint

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Objective Oral lichen planus (OLP) is a chronic inflammatory oral mucosa disease that is recognized as an oral potentially malignant disorder. However, the potentially malignant nature of OLP remains unclear.Materials and Methods We designed this study to examine the demographic and clinical characteristics of OLP and evaluate its malignant potential. A total of 565 patients with a clinical and histopathological diagnosis of OLP who presented at our department between 2001 and 2017 were retrospectively studied. Patients who had clinical and histopathological features of oral lichenoid lesions (OLLs) classified as oral lichenoid contact lesions (OLCLs), oral lichenoid drug reactions (OLDRs) and oral lichenoid lesions of graft-versus-host disease (OLL-GVHD) were excluded.Results The study population included 123 men and 442 women aged 21-93 years (median, 62 years). The 565 patients were followed up for an average duration of 55.9 months, during which 4 (0.7%) patients developed squamous cell carcinoma (SCC). In three of these 4 patients who developed SCC, the clinical type of OLP was the red type.Conclusions Our results suggested that OLP was associated with a low risk of malignant transformation. Further investigation of the clinical risk factors associated with malignant transformation is necessary.Clinical relevance We recommend regular follow-up for OLP patients and clear differentiation of oral epithelial dysplasia (OED) and OLLs to enable early detection of malignant transformation.

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“…20 In 2003, the first-in-human data on a direct antiviral agent (DAA) for HCV were published, and in 2011, the HCV protease inhibitors telaprevir and boceprevir were approved by the US Food and Drug Administration. 28 In 2014, three new HCV DAAs (Sofosbuvir, Simeprevir, and Daclatasvir) were licensed worldwide for use as IFN-free.…”

Section: Last Pieces Of the Jigsawmentioning

confidence: 99%

A personal journey through Oral medicine: The tale of hepatitis C virus and oral lichen planus

Carrozzo

2023

J Oral Pathology Medicine

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Around 30 years ago, the hepatitis C virus (HCV) was identified and soon it was shown that this virus, further to the liver, could affect a variety of organ systems. This article summarizes how an association between HCV and a relatively common oral disorder, oral lichen planus (OLP), was revealed. Through key publications, many of them published in Journal of Oral Pathology and Medicine, it is shown the building of strong epidemiologic evidence supporting the association and how a plausible pathogenic link between HCV and OLP was discovered. As HCV infection is now potentially curable, modern direct antiviral agents can be used to effectively cure also OLP in HCV-infected patients.

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Hepatitis C virus: a silent killer relevant to dentistry

Cited by 5 publications

References 60 publications

Malignant transformation of oral lichen planus: a retrospective study of 565 Japanese patients

Malignant transformation of oral lichen planus: a retrospective study of 565 Japanese patients

Malignant Transformation of Oral Lichen Planus: A Retrospective Study of 565 Japanese Patients

A personal journey through Oral medicine: The tale of hepatitis C virus and oral lichen planus

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