A personal journey through Oral medicine: The tale of hepatitis C virus and oral lichen planus

Carrozzo, Marco

doi:10.1111/jop.13400

Cited by 3 publications

(1 citation statement)

References 33 publications

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“…HCV can also affect the central nervous system, leading to a range of neurological and psychiatric disorders [ 16 ], and it is associated with a variety of rheumatologic conditions [ 17 ] and skin conditions [ 18 , 19 , 20 ]. In summary, the extra-hepatic manifestations of HCV are varied and can involve multiple organ systems.…”

Section: Introductionmentioning

confidence: 99%

Hepatitis C Epidemiology: Insights from a Comprehensive Cohort Study in ASST Melegnano and Martesana, Lombardia Region, Northern Italy

Nardone,

Di Stasio,

Lucchese

et al. 2024

Pathogens

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Hepatitis C virus (HCV) infection is a significant public health problem affecting 58 million people worldwide, including 3.9 million in Europe. Many of these infections go undiagnosed because chronic infection is often asymptomatic. This observational cohort study presents a detailed examination of hepatitis C virus epidemiology in Lombardia (Italy) and was conducted within the ASST “Melegnano e della Martesana”. The study involved comprehensive HCV screening of 3290 patients accessing the collection points and/or hospitalized in the facilities of the ASST from 20 May 2022 to 13 April 2023. Screening was conducted using serological assays. The prevalence of anti-HCV-positive patients (HCV-Ab) and then HCV-positive patients (RNA) was calculated. Chi-square tests examined the associations between continuous and categorical variables. Logistic regression was used to evaluate the influence of demographic and geographic variables as predictors of HCV positivity. The study revealed an overall HCV-Ab prevalence of 0.912% (CI (0.59–1.24%)) in the examined cohort, of whom 15.15% (two females and three males) were positive for HCV RNA. The prevalence of HCV RNA positivity was 0.152% (CI (0.05–0.35%)). Sex disparity was evident, with male patients exhibiting a higher prevalence compared to females, confirmed by logistic regression (0.0147 vs. 0.0061–OR = 2.44; CI (0.0059–0.0124)). Age stratification indicated an ascending trend in prevalence with age, peaking at 1.35% in individuals aged over 50. These findings underscore the critical need for targeted HCV screening, contributing valuable insights to the global epidemiology of HCV in the era of DAAs.

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Section: Introductionmentioning

confidence: 99%

Hepatitis C Epidemiology: Insights from a Comprehensive Cohort Study in ASST Melegnano and Martesana, Lombardia Region, Northern Italy

Nardone,

Di Stasio,

Lucchese

et al. 2024

Pathogens

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Hepatitis C Virus (HCV) Infection: Pathogenesis, Oral Manifestations, and the Role of Direct-Acting Antiviral Therapy: A Narrative Review

Di Stasio,

Guida,

Romano

et al. 2024

JCM

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Hepatitis C virus (HCV) infection is a global health concern with significant systemic implications, including a range of oral manifestations. This review aims to provide a comprehensive overview of the oral and dental pathologies related to HCV, the etiopathogenetic mechanisms linking such conditions to HCV and the impact of direct-acting antiviral (DAA) therapy. Common oral manifestations of HCV include oral lichen planus (OLP), periodontal disease, and xerostomia. The pathogenesis of these conditions involves both direct viral effects on oral tissues and indirect effects related to the immune response to HCV. Our literature analysis, using PubMed, Scopus, Web of Science, and Google Scholar, suggests that both the HCV infection and the immune response to HCV contribute to the increased prevalence of these oral diseases. The introduction of DAA therapy represents a significant advancement in HCV treatment, but its effects on oral manifestations, particularly OLP, are still under evaluation. Although a possible mechanism linking HCV to OSCC is yet to be determined, existing evidence encourages further investigation in this sense. Our findings highlight the need for established protocols for managing the oral health of patients with HCV, aiming to improve outcomes and quality of life.

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Prevention of viral and bacterial infections at a dental appointment. Part 1. Microbiome of the oral cavity and risks of infection in dental offices

Rumyantsev,

Tarasova,

Kuzmina

et al. 2024

Stomatol. vseh

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Prevention of viral and bacterial infection of patients and medical personnel is especially relevant in dental institutions. An analysis of the literature of recent years shows that the risk of such infection is due to the work of a dentist “face to face” with a patient, the formation of airborne aerosols by turbine installations, the use of ultrasound and “Air-flow”, small and large dental instruments. The COVID-19 epidemic has shown how important measures are to prevent infection with viral infections, including in medical institutions. Among the viruses, RNA and DNA containing influenza viruses, herpes simplex, human papillomavirus, cytomegalovirus, Epstein-Barr virus, Zika virus, SARS-CoV-2 are quite contagious. Transmission of human immunodeficiency viruses, hepatitis and others is possible. Bacterial infection from the oral cavity during dental manipulations, especially accompanied by bleeding, can also enter the bloodstream, provoking the development of bacteremia and its more serious consequences in the form of endocarditis, meningitis and other life-threatening general pathology. The first part of the review contains information about the properties of these viruses, methods of infection and diseases caused by them. The second part will be devoted to methods of prevention of viral and bacterial infection in the conditions of the stomatological office.

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A personal journey through Oral medicine: The tale of hepatitis C virus and oral lichen planus

Cited by 3 publications

References 33 publications

Hepatitis C Epidemiology: Insights from a Comprehensive Cohort Study in ASST Melegnano and Martesana, Lombardia Region, Northern Italy

Hepatitis C Epidemiology: Insights from a Comprehensive Cohort Study in ASST Melegnano and Martesana, Lombardia Region, Northern Italy

Hepatitis C Virus (HCV) Infection: Pathogenesis, Oral Manifestations, and the Role of Direct-Acting Antiviral Therapy: A Narrative Review

Prevention of viral and bacterial infections at a dental appointment. Part 1. Microbiome of the oral cavity and risks of infection in dental offices

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