Hepatitis C and renal disease: an update

Meyers, Catherine M.; Seeff, Leonard B.; Stehman‐Breen, Catherine; Hoofnagle, Jay H.

doi:10.1016/s0272-6386(03)00828-x

Cited by 325 publications

(270 citation statements)

References 157 publications

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“…[7] In the Indian context, HBV prevalence in HD patients range from 3.4% to 45% which is higher in comparison to the prevalence of 4.7% in the general population. [2,3]A previous study from India has also reported a prevalence of 11 5% in the HD population.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of Hepatitis B and Hepatitis C in haemodialysis population in a tertiary care centre in north eastern India

Jamil

Bhattacharya

Yunus

et al. 2016

Int J of Biomed & Adv Res

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Background: Prevalence of Hepatitis B Virus (HBV) and Hepatitis C Virus (HCV) in the haemodialysis (HD) population varies between 3.4-45% and 4.3-45.2% respectively which are substantially higher than the prevalence rates in the general population. We conducted a study to estimate the prevalence of HBV and HCV in HD population in a tertiary care centre in north east India. Methods: Prospective single centre observational study conducted in patients attending a HD unit between November 2012 and June 2015. All patients with Chronic Kidney Disease who underwent haemodialysis were included. Patients with Acute Kidney Injury were excluded. Hepatitis B surface antigen (HBsAg) and anti-HCV were tested using specific enzyme-linked immune-sorbent assay (ELISA) kits. Results: 507 patients with a male to female ratio of 1.26:1 were included. Overall mean age was 45.70±17.54 years. (Male= 43.94±17.32years; Female=47.81±17.51years).69.82% of the patients underwent once weekly dialysis. 2.17% were found to be positive for HBV while and 1.38% patients were found to be positive for HCV. HBV-HCV co-infection was seen in 0.20%. All HBV positive patients were males and had previous blood transfusions. Conclusion: HBV and HCV is seen to affect a significant number of the End Stage Renal Disease (ESRD) patients undergoing HD. Measures including safe transfusion practices, vaccination and equipment disinfection should be undertaken to reduce the burden of such infections in ESRD patients.

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Section: Discussionmentioning

confidence: 99%

Prevalence of Hepatitis B and Hepatitis C in haemodialysis population in a tertiary care centre in north eastern India

Jamil

Bhattacharya

Yunus

et al. 2016

Int J of Biomed & Adv Res

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“…[1] Increased morbidity and mortality in HCV-infected HD patients was shown previously [2,3] and explained by a high proportion of cirrhosis and hepatocellular carcinoma of these patients. [4,5] HCV infection has also been studied as a source of increased oxidative stress both in the normal and dialysis populations.…”

Section: Introductionmentioning

confidence: 87%

Effect of Anti-HCV Positivity on Markers of Malnutrition and Inflammation in Hemodialysis Patients

et al. 2007

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Aim. To investigate the influence of anti-HCV positivity on markers of malnutrition and inflammation in hemodialysis (HD) patients. Methods. Stable HD patients who had persistently negative or positive HCV antibodies (at least three) and without elevated aminotransferase levels in routine periodical tests with a duration of more than 12 months were included. Patients with conditions known to be associated with acute-phase responses or clinically active (HCV RNA positive) or advanced liver failure were excluded. Thirty-six anti-HCV-positive patients (22 male, 14 female, mean age 47.3 ± 14.5 years, mean time on HD 72.0 ± 39.0 months), were compared with 36 anti-HCV negative patients with similar age and HD duration (25 male, 11 female, mean age 49.2 ± 13.8 years, mean time on HD 59.7 ± 27.1 months). Malnutrition-Inflammation Score (MIS), a fully quantitative score adopted from subjective global assessment, was recorded for each patient (ranges from 0 to 30). High sensitivity serum C-reactive protein (hs-CRP), interleukin-6 (IL-6), erythrocyte sedimentation rate (ESR), and hematocritcorrected ESR were compared as indices of the degree of inflammation beyond anthropometric evaluation and routine laboratory tests.Results. There was no significant difference in MIS of two groups (6.1 ± 3.2 vs. 5.6 ± 3.2, p > 0.05). In the comparison of components of MIS, co-morbidity including number of years on dialysis was higher in anti-HCV-positive patients (p = 0.04). Anthropometric values and serum levels of hs-CRP, IL-6, ESR, and hematocrit-corrected ESR of two groups were not statistically different from each other (p > 0.05 for all). ALT (p = 0.0001) and AST (p = 0.001) levels were higher in anti-HCV-positive patients. Conclusion. Anti-HCV positivity without active infection seems to have no additional negative effect on malnutrition and inflammation in maintenance HD patients.

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“…The factors favouring HCV infection in CKD are time on dialysis, number of blood transfusions, mode of dialysis haemodialysis > peritoneal dialysis and existing prevalence of HCV infection in the dialysis unit. [32].…”

Section: Managing Hepatitis C Virus Infection In Dialysis Patientsmentioning

confidence: 99%

Conservative Management of Chronic Renal Failure

Narula

Hooda

2007

Medical Journal Armed Forces India

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Hepatitis C and renal disease: an update

Cited by 325 publications

References 157 publications

Prevalence of Hepatitis B and Hepatitis C in haemodialysis population in a tertiary care centre in north eastern India

Prevalence of Hepatitis B and Hepatitis C in haemodialysis population in a tertiary care centre in north eastern India

Effect of Anti-HCV Positivity on Markers of Malnutrition and Inflammation in Hemodialysis Patients

Conservative Management of Chronic Renal Failure

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