Prevalence of Hepatitis B and Hepatitis C in haemodialysis population in a tertiary care centre in north eastern India

Jamil,; Bhattacharya, Prasanta; Yunus, Muhammad; Lyngdoh, Clarissa Jane; Roy, Akash; Talukdar, Kishore Kumar

doi:10.7439/ijbar.v7i6.3356

Cited by 5 publications

(3 citation statements)

References 7 publications

(10 reference statements)

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“…In this study, sero-occurrence of HCV co-infection in HBV patients was found to be low (1.67%) compared to global data, but higher than reported in other parts of India7,12,19. A large multicenter study from the United States assessed the prevalence of HBV/HCV co-infection and found anti-HCV was present in 7% of chronic HBV carriers10.…”

Section: Discussionmentioning

confidence: 41%

Sero-Occurrence of HBV/HCV Co-infection and Levels of Liver Enzymes among Patients at a Tertiary Care Hospital in Central India: a Pilot Study

Desikan¹,

Rangnekar²,

Khan³

et al. 2019

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Introduction: Hepatitis B and C viral infections share common modes of transmission and account for a large proportion of liver disease burden across the globe. Patients with Hepatitis B (HBV) and Hepatitis C virus (HCV) co-infection may have more severe liver disease and are potentially at higher risk for developing hepatocellular carcinoma. The aim of this study was to assess the sero-occurrence of HBV/HCV co-infection by examining the medical records of tertiary care hospital patients in Central India and determine the extent of liver damage based on liver function tests (LFTs).Methods: Patients with a positive test for HBV surface antigen (HBsAg) over a period of 10 years were identified from laboratory records in a tertiary care facility in central India. Records of 51,075 consecutive non-duplicate blood samples were then screened for a positive HBV and HCV tests. LFT, liver enzymes, and bilirubin data were also extracted. Means and standard deviations were determined for continuous variables, and the difference in means was compared using a independent samples t-test. Associations between HBV/HCV co-infection status and demographic variables were calculated using Pearson’s Chi-squared test. A p-value less than 0.05 was considered statistically significant.Results: In this study, 1674 (3.27%) screened patients were positive for HBsAg and the sero-occurrence of co-infection with HCV in HBsAg positive patients was reported in 28 individuals (1.67%). There was no significant gender difference for HBV/HCV co-infection (p>0.05). HBV/HCV co-infection was observed more frequently in the 31-60 year old age group (p=0.001). HBV/HCV co-infected patients had significantly higher levels of liver enzymes and bilirubin than those with HBsAg mono-infection (p=0.001).Conclusion: Liver function tests are potentially important predictors for HBV/HCV coinfection. Screening for HCV co-infection in HBsAg-positive patients is recommended in India. Detection of co-infection may enable timely preventive/therapeutic interventions aimed at preventing progression to hepatocellular carcinoma.

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Section: Discussionmentioning

confidence: 41%

Sero-Occurrence of HBV/HCV Co-infection and Levels of Liver Enzymes among Patients at a Tertiary Care Hospital in Central India: a Pilot Study

Desikan¹,

Rangnekar²,

Khan³

et al. 2019

cajgh

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“…In our study, 23 patients (38.3%) had frequency “once a week” and 22 patients (36.6%) were with a frequency of dialysis “thrice a week.” In a study by Jamil, the majority of the population (69.82%) had once weekly dialysis, whereas 14.40% and 0.79% underwent dialysis on a twice-weekly or thrice-weekly basis. [ 13 ] The frequency of dialysis depends on the patient’s requirement. Due to multiple practices of dialysis, these patients are more prone to HCV and HBsAg infection.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of Hepatitis B and Hepatitis C in Patients undergoing hemodialysis at a teaching hospital in Uttarakhand

Pandita¹,

Raina²,

Rawat³

2022

Journal of Family Medicine and Primary Care

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Introduction: Hemodialysis (HD) requires blood exposure to infectious materials through the extracorporeal circulation for a prolonged period, and exposure to risk factors for nosocomial infections is always there. Aims and Objectives: To determine the prevalence of hepatitis B and hepatitis C in patients undergoing hemodialysis and evaluate the various modes of transmission involved in the causation of the infection. Materials and Methods: A total of 60 patients with chronic kidney disease, admitted to our hospital for HD, were screened for hepatitis B surface antigen (HBsAg) and anti-HCV antibodies. A questionnaire was designed to evaluate risk factors and data were generated to evaluate the significance of the association. Results: Out of 60 subjects, an anti-HCV antibody was detected in 31.68% of patients and 11.66% of patients were positive for HBsAg. The maximum anti-HBV-positive patients were in >60 years of age group (11.53%), whereas the maximum HCV-positive patients were between 41 and 50 age group (23.07%). Most of the HCV-positive patients (54.54%), as well as HBV-positive patients (23.52%), received hemodialysis 50 to 100 times. The major primary disease-causing end-stage renal disease (ESRD) included chronic nephritis (35%). The duration of dialysis, multiple blood transfusions, drug addiction, and body piercing/tattooing were also observed as significant risk factors. Conclusion: In HD patients, viral hepatitis poses a significant health hazard, particularly in developing countries. HBV vaccination, strict adherence to the universal precautions, segregation of HBV-positive patients can control HBV infection in HD units. However, for HCV, the absence of a specific vaccine and the nosocomial transmission of the virus increase the peril more.

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“…The data presented in Table 4 indicate that during the period from 1993 to 2010, the seroprevalence of HCV in HD patients ranged from 12.1% to 46%, [19][20][21][22][23][24][25] whereas studies conducted after 2010 reveal a general decline in prevalence to 12.4%. [26][27][28][29][30] One exception in this regard, however, is a study conducted in Jammu in 2016, which reported a considerably higher prevalence of 31.4%. 31 We speculate that this wide divergence in prevalence could be attributed to a number of contributory factors, including different geographical locations, a different study duration, or differences in the sensitivity and specificity of the methods used for detecting HCV infection.…”

Section: Seroprevalence Of Hcvmentioning

confidence: 99%

Seroprevalence of Hepatitis C Virus Infection among Hemodialysis Patients in A Tertiary Care Hospital in South India

Rajasekaran¹,

Kalpanaraj²,

Banu³

et al. 2023

J. Pure Appl. Microbiol.

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Hepatitis C virus (HCV) infection in hemodialysis patients is mainly associated with insufficient precautionary measures. Compared with the general population, the prevalence of HCV infection is high among hemodialysis patients. HCV infection in these patients is typically associated with increased morbidity and mortality; however, the early detection of HCV may retard disease progression and reduce morbidity and mortality. In this study, we sought to estimate the seroprevalence of HCV infection among patients undergoing hemodialysis in a tertiary care hospital in Chennai, Tamil Nadu, South India. This was a prospective, observational, cross-sectional study that included 82 hemodialysis patients. Blood samples were collected from each patient, and the serum was separated for detection of the presence of HCV antibodies, HCV core antigen, and HCV RNA using an enzyme-linked immunosorbent assay, enzyme immunoassay, and polymerase chain reaction, respectively. Relevant socio-demographic, clinical, and laboratory information was also obtained. Among samples collected from the 82 patients, seven were found to be positive for HCV antibodies, whereas nine and eleven samples were found to be positive for HCV core antigen and HCV RNA, respectively. Long durations of renal failure and hemodialysis were identified as being positively associated with HCV infection in these hemodialysis patients, and a statistically significant reduction in hemoglobin levels and an increase in creatinine levels were detected among the HCV-positive patients. The overall seroprevalence of HCV infection in hemodialysis patients was found to be 13.4%. Given that high rate false-negative reactions were detected using ELISA and EIA, screening of HCV RNA during the early stages of HCV infection can contribute to preventing its nosocomial spread in these patients. Moreover, it is imperative that stringent universal precautionary measures are implemented in all health care settings and hemodialysis units to minimize the risk of HCV transmission.

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Prevalence of Hepatitis B and Hepatitis C in haemodialysis population in a tertiary care centre in north eastern India

Cited by 5 publications

References 7 publications

Sero-Occurrence of HBV/HCV Co-infection and Levels of Liver Enzymes among Patients at a Tertiary Care Hospital in Central India: a Pilot Study

Sero-Occurrence of HBV/HCV Co-infection and Levels of Liver Enzymes among Patients at a Tertiary Care Hospital in Central India: a Pilot Study

Prevalence of Hepatitis B and Hepatitis C in Patients undergoing hemodialysis at a teaching hospital in Uttarakhand

Seroprevalence of Hepatitis C Virus Infection among Hemodialysis Patients in A Tertiary Care Hospital in South India

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