Hepatitis B virus occult infection in subjects with persistent isolated anti-HBc reactivity

Sánchez-Quijano, A; Jauregui, J.I.; Leal, Manuel; Pineda, Juan A.; Castilla, Alberto; Abad, M. A.; Civeira, M.P.; Pesquera, F. García de; Prieto, Jesús; Lissén, E

doi:10.1016/s0168-8278(05)80207-7

Cited by 51 publications

(32 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Thus, NAFLD may account for a substantial proportion of NBNC HCC in developed, low HBV-endemic areas. However, these findings cannot be directly generalized to highly HBV-endemic areas because occult HBV infection is frequently associated with cryptogenic liver disease and subsequent development of HCC in these areas [20,21]. According to a retrospective study of 565 HCC patients at a tertiary center in Korea, more than 60% of the patients with NBNC-NA-NS HCC were positive for isolated anti-HBc, while no patient had NAFLD-related HCC [22].…”

Section: Discussionmentioning

confidence: 99%

Relative Etiological Role of Prior Hepatitis B Virus Infection and Nonalcoholic Fatty Liver Disease in the Development of Non-B Non-C Hepatocellular Carcinoma in a Hepatitis B-Endemic Area

et al. 2011

View full text Add to dashboard Cite

Background and Aims: We investigated the relative etiological role of prior hepatitis B virus (HBV) infection and nonalcoholic fatty liver disease (NAFLD) in the development of non-B non-C, non-alcohol or specific cause-related hepatocellular carcinoma (NBNC-NA-NS HCC) in an HBV-endemic area of Korea. Methods: A total of 329 patients with NBNC-NA-NS HCC were enrolled in this study. Prior HBV infection was defined as the presence of isolated IgG hepatitis B core antibody (anti-HBc), and NAFLD was diagnosed by the findings from the imaging in the absence of a history of excessive alcohol consumption. Results: Prior HBV infection was the most common cause of underlying liver disease (76.6%). Only 8.2% of the patients had NAFLD as the only risk factor and the same proportion of patients had evidence of both prior HBV infection and NAFLD. Patients without definitive causes accounted for 7.0% of the cases. During the past 10 years, the relative proportion of isolated IgG anti-HBc-positive HCC decreased significantly from 86.6% in 2001–2005 to 67.4% in 2006–2010 (p < 0.0001) and that of NAFLD-related HCC increased from 3.8% to 12.2% in the same period, respectively (p = 0.008). The mean age of NAFLD-related HCC patients (67.3 years) was significantly older than that of HCC patients related to prior HBV infection (61.2 years, p < 0.001). Conclusions: NAFLD-related HCC increased significantly while HCC related to prior HBV infection decreased during the past 10 years in an HBV-endemic area of Korea; however, the relative etiological role of prior HBV infection was still greater than that of NAFLD in the development of NBNC-NA-NS HCC.

show abstract

Section: Discussionmentioning

confidence: 99%

Relative Etiological Role of Prior Hepatitis B Virus Infection and Nonalcoholic Fatty Liver Disease in the Development of Non-B Non-C Hepatocellular Carcinoma in a Hepatitis B-Endemic Area

et al. 2011

View full text Add to dashboard Cite

show abstract

“…With the development of sensitive assays to detect HBV-DNA it was shown that healthy HBsAg-negative donors who have antibodies to HBV core antigen (antiHBc) may harbor an occult HBV infection and maintain HBV-DNA sequences in their liver and blood, thus representing potential sources of HBV transmission. [6][7][8][9][10][11][12][13][14][15][16][17] AntiHBc screening of blood donations is controversial and variably performed in different countries. Currently it is limited to areas where the seroprevalence of HBV is low (generally <2%), while it is not performed in areas with a high HBV seroprevalence because the impact of the deferral of anti-HBc-positive donors is considered not sustainable.…”

mentioning

confidence: 99%

Italian blood donors with anti-HBc and occult hepatitis B virus infection

Manzini¹,

Girotto²,

Borsotti³

et al. 2007

Haematologica

View full text Add to dashboard Cite

“…The failure to detect HBsAg, despite the persistence of the viral DNA, is due in most cases to the strong suppression of viral replication and gene expression that characterizes this "occult" HBV infection [6][7][8][9]; although the mechanisms responsible for suppression of HBV are not well understood.…”

mentioning

confidence: 99%

Occult hepatitis B virus infection in immunocompromised patients

Jardim¹,

Gonçales²,

Pereira³

et al. 2008

Braz J Infect Dis

View full text Add to dashboard Cite

Occult hepatitis B infection is characterized by hepatitis B virus (HBV) DNA in the serum in the absence of hepatitis B surface antigen (HBsAg). We assessed occult HBV infection prevalence in two groups of immunocompromised patients (maintenance hemodialysis patients and HIV-positive patients) presenting HBsAgnegative and anti-HBc positive serological patterns, co-infected or not by HCV. Thirty-four hemodialysis anti-HIV negative patients, 159 HIV-positive patients and 150 blood donors who were anti-HBc positive (control group) were selected. HBV-DNA was detected by nested-PCR. Occult hepatitis B infection was not observed in the hemodialysis patients group but was found in 5% of the HIV-patients and in 4% of the blood donors. Immunosuppression in HIV positive patients was not a determining factor for occult HBV infection. In addition, no significant relationship between HBV-DNA and HCV co-infection in the HIV-positive patient group was found. A lack of significant associations was also observed between positivity for HBV-DNA and CD4 count, viral load and previous lamivudine treatment in these HIV-positive patients.

show abstract

Hepatitis B virus occult infection in subjects with persistent isolated anti-HBc reactivity

Cited by 51 publications

References 35 publications

Relative Etiological Role of Prior Hepatitis B Virus Infection and Nonalcoholic Fatty Liver Disease in the Development of Non-B Non-C Hepatocellular Carcinoma in a Hepatitis B-Endemic Area

Relative Etiological Role of Prior Hepatitis B Virus Infection and Nonalcoholic Fatty Liver Disease in the Development of Non-B Non-C Hepatocellular Carcinoma in a Hepatitis B-Endemic Area

Italian blood donors with anti-HBc and occult hepatitis B virus infection

Occult hepatitis B virus infection in immunocompromised patients

Contact Info

Product

Resources

About