Hepatitis B virus is associated with the clinical features and survival rate of patients with intrahepatic cholangiocarcinoma

Luan, Tao; He, Xiaodong; Xiu, Dianrong

doi:10.1016/j.clinre.2016.04.001

Cited by 25 publications

(26 citation statements)

References 25 publications

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“…Research of Zhou et al [42] and Peng et al [27] further indicated that neutrophilic infiltration was found to be more common in HBV-associated ICC patients. More recently, Tao et al [28] found that prothrombin time was also found to be higher in HBV-associated ICC patients (P = 0.030), complementing the studies from Zhou et al [42] and Peng et al [27]. The above mentioned clinicopathological characteristics of HBV-associated ICC were verified by a meta-analysis that involved 14 studies and 2842 cases [43].…”

Section: Clinicopathological Characteristicsmentioning

confidence: 75%

“…Moreover, Liu et al [55] observed this phenomenon from a different point of view and discovered that both HBV infection and vaccination prior to surgical treatment, combined with preoperative adjuvant chemotherapy, were found to be independent prognostic factors that improved survival outcomes of patients when undergoing hepatic resection for ICC. On the contrary, Tao et al [28] described that 1-, 3-, and 5-year cumulative survival rates of HBsAg-positive ICC patients are significantly lower than HBV-negative ICC patients (27.3%, 0%, and 0% vs. 87.5%, 66.7%, and 50.0%, P < 0.001). More recently, Ahn et al [5] analyzed the survival outcomes of 37 HBV-associated and 255 HBV-negative ICC patients who underwent hepatic resection, and demonstrated that their postoperative outcomes showed no significant difference, but more favorable tumor features were observed in HBV-associated ICC patients due to a relatively earlier diagnosis.…”

Section: Survival Outcomesmentioning

confidence: 99%

“…In previous relevant publications, the distribution of HBV-associated ICC was found to vary worldwide with the lowest distribution found in US (1/625, 0.2%; 1/83, 1.2%) and the highest in China (154/317, 48.6%; 31/98, 31.6%; 26/97, 26.8%) [25–28]. The other Asian countries such as Korea (4/51, 7.8%; 84/622, 13.5%; 37/292, 12.7%) and Japan (2/50, 4%; 3/41, 7.3%) were found to have a moderate distribution of HBV-associated ICC [5, 8, 29–31].…”

Section: Hbv Infection and The Development Of Iccmentioning

confidence: 99%

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Hepatitis B virus-associated intrahepatic cholangiocarcinoma: a malignancy of distinctive characteristics between hepatocellular carcinoma and intrahepatic cholangiocarcinoma

et al. 2016

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It has been a decade since hepatitis B virus infection was identified as an etiological factor for the development of intrahepatic cholangiocarcinoma (ICC). In recent years, several studies have elucidated the critical impact of hepatitis B virus in ICC that significantly influenced the clinicopathological characteristics of ICC patients with intrahepatic cholangiocarcinoma. Distinctive features of patients with hepatitis B virus-associated ICC included younger age, preponderance of male patients, frequent elevation of alpha-fetoprotein, and infrequent lymph node metastasis. Furthermore, several studies indicated that the presence of hepatitis B virus is a favorable prognostic factor in terms of overall survival and relapse-free survival. However, there are also a few studies demonstrating that hepatitis B virus negatively influenced or showed no significant association with survival outcomes of patients with ICC. At present, there are no consensus on diagnostic procedures and treatments for such population. Therefore, we elucidated current knowledge and recent identifications of HBV-associated ICC to clarify the impact of chronic HBV infection on patients with ICC and to precisely conduct diagnostic procedures and curative treatments for HBV-associated ICC.

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Section: Clinicopathological Characteristicsmentioning

confidence: 75%

Section: Survival Outcomesmentioning

confidence: 99%

Section: Hbv Infection and The Development Of Iccmentioning

confidence: 99%

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Hepatitis B virus-associated intrahepatic cholangiocarcinoma: a malignancy of distinctive characteristics between hepatocellular carcinoma and intrahepatic cholangiocarcinoma

et al. 2016

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“…Unfortunately, the presence of HBV infection was excluded in Wang’s nomogram. On the contrary, Tao et al [21] indicated that HBV infection negatively influenced prognosis of patients with ICC. Another publication from Korea showed that there was no impact of HBV infection on survival outcomes of patients with ICC, and they suggested that early diagnosis of unexpected ICC in HBV carriers might result in relatively favorable outcomes [22].…”

Section: Discussionmentioning

confidence: 99%

Risk stratification system to predict recurrence of intrahepatic cholangiocarcinoma after hepatic resection

et al. 2017

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BackgroundPrevious nomograms for intrahepatic cholangiocarcinoma (ICC) were conducted to predict overall survival, which could be influenced by various factors. Herein, we conducted our nomogram to predict recurrence of the tumor only after hepatic resection.MethodsThe nomogram was established with prognostic factors for the relapse-free survival (RFS) analyzed from our single center cohort and was evaluated by comparing with the American Joint Committee on Cancer (AJCC) staging system for the predictive accuracy.ResultsSeropositivity of hepatitis B surface antigen (hazard ratio [HR], 0.505; 95% confidence interval [CI], 0.279 to 0.914; P = 0.024), tumor size of larger than 5 cm (HR, 1.947; 95% CI, 1.177 to 3.219; P = 0.009), Child-Pugh score of B (HR, 3.067; 95% CI, 1.293 to 7.275; P = 0.011), and lymph node metastasis (HR, 2.790; 95% CI, 1.628 to 4.781; P < 0.001) were found to be independent prognostic factors that significantly affected RFS. The calibration curve for the prediction revealed excellent agreement between estimation by our stratification system and actual RFS. The concordance C index of the nomogram (0.71; 95% CI, 0.65 to 0.77) revealed to be significantly higher than the AJCC staging system (0.66; 95% CI, 0.60 to 0.72). In the validation cohort, our risk stratification system (C-index 0.65; 95% CI, 0.59 to 0.71) also revealed more precise prediction than the AJCC staging system (C-index, 0.57; 95% CI, 0.50 to 0.64).ConclusionsOur nomogram could more accurately predict recurrence of ICC after hepatic resection than the AJCC staging system.

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“…Firstly, for biochemical markers, there was a study reporting HBV infection was associated with higher alanine aminotransferase (ALT) levels, and 2 studies with higher aspartate aminotransferase (AST) levels (11,12). One study has reported the HBV-associated group having lower gamma-glutamyl transferase (GGT) levels, but other studies showed no differences in GGT levels between HBV-associated and non-HBV-associated ICCs (11)(12)(13)(14). The rest of the studies did not find any significant differences liver enzymes levels between the 2 groups (13)(14)(15)(16).…”

Section: Clinical Characteristics Of Hbv-associated Iccmentioning

confidence: 99%

Hepatitis B virus-Associated Intrahepatic Cholangiocarcinoma Has Distinct Clinical, Pathological and Radiological Characteristics: A Systematic Review

Ng¹,

Khoo²,

Velaga³

et al. 2019

SGO

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Intrahepatic cholangiocarcinoma (ICC) is a rare hepatic malignancy with a poor prognosis. It is known that Hepatitis B is both a risk factor and a prognosis factor for ICC. However, little is known about the clinical, pathological and radiological characteristics of ICC patients with hepatitis B virus (HBV) infection. A systematic review of relevant literature was performed using PubMed and EMBASE databases. HBV-associated ICC revealed several unique and interesting features, it was found to have higher alpha-fetoprotein (AFP), cancer antigen 19-9 (CA 19-9) levels, capsule formation and cirrhosis, but associated with lower lymph node metastasis. Radiologically, it was shown that some of the HBV-associated ICC tend to mimic atypical radiological features of HCC. Pathologically, it was found that HBx protein gene expression was associated with HBV-associated ICC, and that hepatic progenitor cells may be an alternative origin for HBV-associated ICC. In conclusion, HBV-associated ICC has distinct clinical, pathological and radiological characteristics, but further research is needed to further understand the pathogenesis of the disease.

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Hepatitis B virus is associated with the clinical features and survival rate of patients with intrahepatic cholangiocarcinoma

Cited by 25 publications

References 25 publications

Hepatitis B virus-associated intrahepatic cholangiocarcinoma: a malignancy of distinctive characteristics between hepatocellular carcinoma and intrahepatic cholangiocarcinoma

Hepatitis B virus-associated intrahepatic cholangiocarcinoma: a malignancy of distinctive characteristics between hepatocellular carcinoma and intrahepatic cholangiocarcinoma

Risk stratification system to predict recurrence of intrahepatic cholangiocarcinoma after hepatic resection

Hepatitis B virus-Associated Intrahepatic Cholangiocarcinoma Has Distinct Clinical, Pathological and Radiological Characteristics: A Systematic Review

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