Hepatitis B virus infection in patients with metabolic syndrome: A complicated relationship. Results of a population based study

Jarčuška, Peter; Janíčko, Martin; Kružliak, Peter; Novák, Miroslav; Veselíny, Eduard; Fedačko, Ján; Senajová, Gabriela; Dražilová, Sylvia; Gecková, Andrea Madarasová; Mareková, Mária; Pella, Daniel; Siegfried, Leonard; Kristián, Pavol; Kolesárová, Eva

doi:10.1016/j.ejim.2014.01.006

Cited by 36 publications

(37 citation statements)

References 23 publications

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“…The heterogeneity also decreased in subgroups stratified by sex; the conclusion was identical to the total pooled OR (Table 4). Additionally, six studies [13, 16, 26, 27, 34, 43] reported the OR of BMI, and the pooled OR was 0.99 (95% CI, 0.95–1.04; I 2 = 0%, P = 0.65), which was consistent with WC.…”

Section: Resultssupporting

confidence: 54%

“…Jarčuška et al . [16] considered that MetS must present with central obesity. Increased BP was defined as systolic BP ≥ 140 mmHg or diastolic BP ≥ 90 mmHg in three studies [13, 27, 42] and as systolic BP ≥ 135 mmHg or diastolic BP ≥ 90 mmHg in one study [14].…”

Section: Resultsmentioning

confidence: 99%

“…For “Elevated TG”, the pooled OR was from 14 studies [10–16, 26, 28, 30, 31, 33–35], and the SMD was from 14 studies [10, 16, 17, 26, 31, 34, 36, 37, 39, 42, 44–47]. They are not identical.…”

Section: Resultsmentioning

confidence: 99%

“…Eleven studies [10–12, 14–16, 26, 28, 30, 33, 43] involving 606,706 HBsAg-positive subjects and 138,369,865 healthy controls reported the OR for HBsAg positivity and increased WC. The pooled OR was 0.97 (95% CI, 0.91–1.04; I 2 = 50%, P = 0.03) (S1 Fig), indicating that HBsAg positivity was neither a risk factor nor a protective factor for increased WC, and further subgroup analysis grouped according to quality assessment confirmed this.…”

Section: Resultsmentioning

confidence: 99%

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Serum HBV surface antigen positivity is associated with low prevalence of metabolic syndrome: A meta-analysis

Li¹,

Zhao²,

Wu³

2017

PLoS ONE

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Background and aimAs there is conflicting evidence for the relationship between hepatitis B virus surface antigen (HBsAg) positivity and the prevalence of metabolic syndrome (MetS), we performed a meta-analysis to investigate whether HBsAg positivity affects the incidence of MetS.MethodsObservational studies on the relationship between HBsAg positivity and MetS were obtained from PubMed, Web of Science, and the Cochrane Library in April 2016. The pooled odds ratios (ORs) of MetS and its components (central obesity, increased fasting glucose, increased blood pressure, dyslipidemia) for subjects with or without HBsAg positivity were synthesized. The standardized mean difference of MetS components between HBsAg-positive participants and healthy controls was calculated. Heterogeneity was explored with subgroup analysis and sensitivity analysis. Publication bias was detected using Egger’s test and Begg’s test.ResultsThirty studies were eligible for meta-analysis. The MetS OR for HBsAg-positive participants was significantly decreased compared with the controls [OR = 0.80, 95% confidence interval (CI), 0.70–0.90]. The negative effect of HBsAg positivity on elevated triglycerides (OR = 0.62, 95% CI, 0.59–0.64) was strong, while that for increased fasting blood glucose was weak (OR = 0.94, 95% CI, 0.90–0.98). The pooled ORs of central obesity (OR = 0.97, 95% CI, 0.91–1.04), reduced high-density lipoprotein cholesterol (OR = 0.98, 95% CI, 0.83–1.14), and elevated blood pressure (OR = 1.00, 95% CI, 0.80–1.25) for HBsAg-positive participants were all not significantly different compared with the controls. No publication bias was detected.ConclusionsSerum HBsAg positivity is inversely associated with the prevalence of MetS. Among the five components of MetS, elevated triglycerides had the strongest inverse relationship with HBsAg positivity.

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Section: Resultssupporting

confidence: 54%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Serum HBV surface antigen positivity is associated with low prevalence of metabolic syndrome: A meta-analysis

Li¹,

Zhao²,

Wu³

2017

PLoS ONE

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“…This study was cross-section study design it included subjects from 2 months to elder. Two independent cross-section studies from Taiwan [27] and Slovakia [28] showed that there was no association between HBV and MS, in Taiwan’s study no individual components of MS was associated with HBV infection but opposite result found in Slovakia’s study that HBV infection may decrease level of TC and LDL. In other cross-section study from Taiwan showed that compared with healthy person, patients with chronic HBV infection had lower level of TG and LDL [29].…”

Section: Discussionmentioning

confidence: 93%

Association between hepatitis B virus infection and metabolic syndrome: a retrospective cohort study in Shanghai, China

et al. 2014

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BackgroundMetabolic syndrome (MS) and hepatitis B (HBV) infection are two major public health problems in China. There are few studies about their association, and the results of these studies are contradictory. We conducted a retrospective cohort study to assess the association between MS and HBV in a Shanghai community-based cohort.MethodsNine hundred seventy-six Shanghai residents were recruited from the Putuo community. 480 HBV infections were in exposed group and 496 non-infections in unexposed group. All metabolic-related parameters and hepatitis B serology were tested with routine biochemical or immunological methods. “Exposed” was defined by HBV infection represented by hepatitis B surface antigen (HBsAg) and without anti-virus treatment. “Unexposed” were subjects who didn’t infect with HBV (Represented by HBsAg) and no MS when they entered the cohort. MS was defined based on the updated National Cholesterol Education Program Adult Treatment Panel III criteria. The Cox proportional hazards model was used to estimate the hazard ratios (HR) and related 95% confidence intervals (95% CI) for the association between HBV infection and MS over a 20-year follow-up period.ResultsOf 976 subjects recruited, 480 had latent HBV infection (exposed subjects). After adjusting for age, the crude HR was 2.46 (95% CI: 1.77, 3.41). After adjusting for potential risk factors of MS (age, gender, smoking, passive smoking, alcohol consumption, physical activity, and diet), the HR was 2.27 (95% CI: 1.52, 3.38).ConclusionsThis 20-year follow-up retrospective cohort study in Shanghai showed a positive association between HBV infection and MS.

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Prevalence of, and biochemical and anthropometric risk factors for, dyslipidemia in children and adolescents aged 7 to 18 years in China: A cross‐sectional study

Pan

et al. 2019

American J Hum Biol

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ObjectiveThis study aimed to investigate the prevalence of dyslipidemia and its risk factors in children and adolescents aged 7 to 18 years in China.MethodsA cross‐sectional study was conducted from November, 2013 to July, 2014. A total of 2283 children and adolescents from urban and rural areas in Hainan (South China) and Shaanxi Provinces (Northwest China) were selected using multi‐stage stratified cluster sampling method. Each participant underwent anthropometric and serum biochemical tests which included serum lipids and hepatitis B virus surface antigen (HBsAg).ResultsThe overall prevalence of high total cholesterol (TC), high triglyceride (TG), high low‐density lipoprotein cholesterol (LDL‐C), low high‐density lipoprotein cholesterol (HDL‐C), hyperlipidemia and dyslipidemia were 6.5%, 7.5%, 5.2%, 9.1%, 14.3%, and 20.6%, respectively. After standardization by age, girls had higher prevalence of high TC (8.2%), high LDL‐C (6.6%), and hyperlipidemia (16.4%), but lower prevalence of low HDL‐C (8.21%) than boys (4.2%, 3.4%, 11.9%, and 11.3%, respectively). The risk of dyslipidemia increased with age (OR = 1.067, 95% CI: 1.030‐1.106). Boys had a decreased risk of dyslipidemia (OR = 0.798, 95% CI: 0.640‐0.994). The restricted cubic spline revealed a linear relationship between BMI and the risk of dyslipidemia (P < .001). Subjects who were HBsAg positive had higher risk of dyslipidemia (OR = 1.550, 95% CI: 1.050‐2.287) compared with those who were HBsAg negative.ConclusionsOur study highlights the high prevalence of dyslipidemia in youth in China, and is the first study to reveal a positive association between positive status for HBsAg and abnormal lipid levels in children and adolescents.

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Hepatitis B virus infection in patients with metabolic syndrome: A complicated relationship. Results of a population based study

Cited by 36 publications

References 23 publications

Serum HBV surface antigen positivity is associated with low prevalence of metabolic syndrome: A meta-analysis

Serum HBV surface antigen positivity is associated with low prevalence of metabolic syndrome: A meta-analysis

Association between hepatitis B virus infection and metabolic syndrome: a retrospective cohort study in Shanghai, China

Prevalence of, and biochemical and anthropometric risk factors for, dyslipidemia in children and adolescents aged 7 to 18 years in China: A cross‐sectional study

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