Hepatitis B Virus in Chronically Infected Patients

Basaras, Miren; Arrese, E.; Blanco, Sonia; Sota, M.; Heras, Begoña de las; Cisterna, R

doi:10.1016/j.ijid.2008.05.1236

Cited by 4 publications

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“…Genotypes A and D were predominant in both group of individuals. This distribution is similar to other European studies that confirm the predominance of these two genotypes, particularly in Mediterranean countries (Basaras et al, 2007;Echevarria and Leon, 2004;Sanchez-Tapias et al, 2002). In our group of individuals, no relationships between HBV genotypes and the presence of extrahepatic manifestations were evidenced in patients with chronic HBV infection.…”

Section: Discussionsupporting

confidence: 91%

Alcohol consumption among patients with hepatitis B infection in northern Portugal considering gender and hepatitis B virus genotype differences

Mota¹,

Guedes²,

Areias³

et al. 2010

Alcohol

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Alcohol abuse is an important public health problem. In Portugal with a population of 10 millions of inhabitants, there are around 10% of alcoholics or excessive alcohol drinkers and 1% of chronically infected patients with hepatitis B virus (HBV). To examine the characteristics of patients with higher levels of alcohol consumption and to investigate the association between alcohol consumption and liver damage a total of 298 chronically infected individuals, with HBV genotyped and submitted to liver biopsy, were classified with Child's grading and separated by habits of alcohol intake, less and greater than 20 g/day. No significant differences were observed about genotype but genotypes A and D were predominant in both of them. A higher percentage of males (P ! .001) were observed in the group with alcohol intake above 20 g/day, as well a lower proportion of patients with HBeAg negativity (P #.035). In this group, biochemistry parameters, such as alanine aminotransferase (P 5 .006), aspartate aminotransferase (P 5 .001), gamma-glutamyl transferase (P ! .001) were elevated in a significantly higher proportion than in the other group. The analysis of hematological parameters showed significantly lower values of platelets (P 5 .042) and mean corpuscular volume (P ! .001) and significantly higher values of prothrombin time (P ! .001) in the group with higher levels of alcohol consumption. The characteristics of biopsy (P ! .001) and ChildePhug's classification (P 5 .002) revealed more severe results in this group. Logistic regression showed a positive association between liver damage and alcohol intake, increasing with age. In female patients, a strong positive association between alcohol intake and liver damage was also found (odds ratio: 9.379; 95% confidence interval: 0.859e468.422; P 5 .037); however, the most severe cases were only observed in women older than 45 years. In patients with HBV infection, alcohol is associated with a more severe liver disease. No evidence was found concerning association with HBV genotype. Ó

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Section: Discussionsupporting

confidence: 91%

Alcohol consumption among patients with hepatitis B infection in northern Portugal considering gender and hepatitis B virus genotype differences

Mota¹,

Guedes²,

Areias³

et al. 2010

Alcohol

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“…This genotypic distribution seems not to be dependent on sex (p = 0.173), and corresponds to the so-called "Mediterranean pattern." 2,8,19 Almost all subjects were born in Portugal (93.6%), followed by males originating from Portuguesespeaking countries such as Angola, Mozambique, São Tomé e Príncipe, and Guinea-Bissau, all former Portuguese colonies in Africa. Immigration from Asia seems to have introduced genotype C among the Portuguese population, and the only two cases of infection with this genotype were of Chinese origin.…”

Section: Discussionmentioning

confidence: 99%

Perfil epidemiológico e genotípico da infecção pelo vírus da hepatite B no Norte de Portugal

et al. 2010

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OBJECTIVO: Descrever o perfil epidemiológico e genotípico da infecção crônica pelo vírus da hepatite B na Região Norte de Portugal. MÉTODOS: Foram incluídos 358 indivíduos oriundos das consultas de especialidade que apresentavam resultados positivos para o antígeno da hepatite B durante pelo menos seis meses em dois hospitais do Norte de Portugal em 2008 e 2009. Os dados foram obtidos a partir dos processos clínicos, determinações laboratoriais feitas quando da genotipagem do vírus, ecografia e/ou ultra-sonografia e biópsia hepática. As características demográficas, marcadores víricos, carga viral e genótipos, e severidade da doença hepática foram avaliadas e comparadas entre sexos. RESULTADOS: Os genótipos A e D predominaram. A transmissão intrafamiliar ocorreu predominantemente nas mulheres. Um terço das mulheres apresentava ingestão alcoólica superior a 20 g/dia, aumentando para 58,9% nos homens. A ausência do AgHBe foi semelhante nos dois sexos (p = 0,662). Os parâmetros bioquímicos em geral apresentaram-se com valores mais altos nos homens, assim como nos estágios necro-inflamatório e de esteatose hepática (p = 0,003). CONCLUSÕES: As diferenças relativas às vias de transmissão da infecção pelo vírus da hepatite B entre homens e mulheres podem ser conseqüência de comportamentos de risco associadas ao género. A ingestão excessiva de álcool é predominante nos indivíduos do sexo masculino, assim como maior severidade da doença hepática em relação às mulheres.

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“…A previous study in the North of Portugal [Mota et al, 2009] found genotypes A and D to be predominant, with genotype D accounting for 60.1% and genotype A accounting for 30.1% of the patients evaluated. In Spain, the only country that borders Portugal, genotypes A and D have been also found to be prevalent [Echevarria and Leon, 2004; Basaras et al, 2007], although the relationship with the stage of cirrhosis is undocumented. A study in India found that genotype D was associated with more severe liver diseases when compared with genotype A. Genotype D was more prevalent in HCC patients less than 40 years of age, when compared with asymptomatic carriers [Thakur et al, 2002].…”

Section: Discussionmentioning

confidence: 99%

Chronic liver disease and cirrhosis among patients with hepatitis B virus infection in northern Portugal with reference to the viral genotypes

Mota¹,

Areias²,

Cardoso³

2010

Journal of Medical Virology

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International audienceThe prevalence of infection with hepatitis B virus in Portugal is around 1% of the population; 20-30% of those infected typically develop cirrhosis. The study focuses on the epidemiological profile of patients with hepatitis B infection and liver damage, in particular, cirrhosis. Of the 358 individuals that comprised the study, a liver biopsy was performed in 249 to identify the presence of cirrhosis. Cirrhosis was observed in 59 patients (23.7%) The Child-Pugh classification was used to assess the prognosis of cirrhosis: 3 out of the 59 patients were classified as Child-Pugh grade C, the most severe, 17 (28.8%) as grade B and 39 (66.2%) as grade A. Patients classified as grade B were older, drank more and showed higher levels of AST and alkaline phosphatase when compared with individuals classified as grade A. Genotypes A and D were predominant, and no significant differences with respect to genotype distribution were observed. Analysis of the haematological parameters showed that patients classified as Child's grade B had lower levels of Platelets and higher levels of prothrombin time than those classified as Child's grade A. The profile of the patients with cirrhosis, including an extended number of individual characteristics, provides useful information, however, only a prospective study could evaluate definitively if liver disease is influenced by these factors. Future studies would benefit from the analysis of the impact of genotypes on liver disease, particularly genotypes A and D, the most predominant genotypes in northern Portugal

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Hepatitis B Virus in Chronically Infected Patients

Cited by 4 publications

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Alcohol consumption among patients with hepatitis B infection in northern Portugal considering gender and hepatitis B virus genotype differences

Alcohol consumption among patients with hepatitis B infection in northern Portugal considering gender and hepatitis B virus genotype differences

Perfil epidemiológico e genotípico da infecção pelo vírus da hepatite B no Norte de Portugal

Chronic liver disease and cirrhosis among patients with hepatitis B virus infection in northern Portugal with reference to the viral genotypes

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