Hepatitis B Virus (HBV) and Autoimmune Disease

Ram, Maya; Gershwin, M. Eric; Shoenfeld, Yehuda

doi:10.1007/s12016-007-8013-6

Cited by 110 publications

(85 citation statements)

References 93 publications

(226 reference statements)

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“…In fact, a study showed that very few patients with AIH had specific antibodies against HCV suggesting that most of them had never encountered this virus [93] . Other hepatitis-causing viruses such as hepatitis A and B viruses (HAV, HBV) have been proposed as triggers for AIH [94][95][96][97][98] . The Epstein-Barr virus (EBV), has been associated with AIH in several case reports and in a clinical follow-up of 13 patients [66][67][68][69] .…”

Section: Molecular Mimicrymentioning

confidence: 99%

“…Hepatitis A virus Case reports [94][95][96] Hepatitis B virus Case reports [97,98] Hepatitis C virus Specific AIH autoantibodies [87][88][89] Cross-Reactivity at T and B-cell level [90][91][92] Epstein-Barr virus Case reports [66][67][68][69] Human herpes virus 6 Sequence similarities [99] Herpes simplex virus Sequence similarities [102] Cross-reactivity at B-cell level [102] 1030…”

Section: Evidences Referencesmentioning

confidence: 99%

See 1 more Smart Citation

Influence of genes, sex, age and environment on the onset of autoimmune hepatitis

Béland¹,

Lapierre²,

Álvarez³

2009

WJG

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Section: Molecular Mimicrymentioning

confidence: 99%

Section: Evidences Referencesmentioning

confidence: 99%

Influence of genes, sex, age and environment on the onset of autoimmune hepatitis

Béland¹,

Lapierre²,

Álvarez³

2009

WJG

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“…The joints, muscle, and skin are the main locations of these clinical manifestations. Autoimmune diseases and LPDs, such as malignant lymphoma and mixed cryoglobulinemia, are also common disorders 9 . Furthermore, asymptomatic disorders of immunologic and LPD markers have been observed in patients with CH-B, as well as in patients with CH-C.…”

Section: Discussionmentioning

confidence: 99%

High Level of Rheumatoid Factor is Associated with Hepatitis B Viremia in Patients with Chronic Hepatitis B

Arai

Ito

Miyashita

et al. 2014

Showa Univ J Med Sci

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: Hepatitis viruses are causative agents for chronic hepatitis, liver cirrhosis and hepatocellular carcinoma. However these viruses are also associated with lymphoproliferative disorders LPDs , such as essential mixed cryoglobulinemia and B-cell non-Hodgkin s lymphoma. Indeed, hepatitis C virus infection has been confirmed to be associated with LPDs, but the pathogenic mechanism remains unclear. In this study, we investigated the relationship between hepatitis B virus HBV infection and LPDs in 84 patients with chronic hepatitis B CH-B . LPD markers, such as cryoglobulinemia, high levels of rheumatoid factor RF , hypocomplementemia, and B cell clonality, were measured and analyzed along with viral factors. Results showed that high levels of RF were observed in 39.5 of patients with CH-B. These high RF levels were not associated with abnormal levels of other LPD markers, but only with the presence of HBV DNA in the sera of these patients. Undergoing therapy with nucleotide analogues was also associated with high RF. In two patients with CH-B, decreasing levels of RF were observed during antiviral therapy. In conclusion, high RF levels are associated with HBV viremia in patients with CH-B. HBV infection also plays an important role in the genesis of LPDs in patients with viral hepatitis..

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“…However, several studies have suggested that HBV infection may result in some autoimmune diseases such as glomerulonephritis and polyarteritis nodosa. 15 As newer, more potent immunomodulatory agents are used for rheumatic diseases, these issues will become increasingly important. Future prospective investigations with larger populations are needed.…”

Section: Declaration Of Conflicting Interestsmentioning

confidence: 99%

Acute Hepatic Failure Caused by Hepatitis B Virus Reactivation in Patients Receiving Immunomodulatory Agents for Autoimmune Diseases

Hsu

Lee

et al. 2014

Arch Rheumatol

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Objectives:The increasing use of novel immunomodulators, such as rituximab, leflunomide and adalimumab in the treatment of autoimmune diseases may put hepatitis B virus (HBV) carriers at increased risk for reactivation and consequent hepatic failure. Patients and methods:We assessed 164 patients newly registered as liver transplant candidates at the National Taiwan University Hospital in 2010. Four patients (2.4%) also had underlying autoimmune disease and received immunomodulatory therapy which resulted in HBV reactivation and acute liver failure, which manifested as progressive hyperbilirubinemia and coagulopathy. The median time of survival of these patients was estimated using the Kaplan-Meier method. Results: All four patients were previously healthy HBV carriers with e antigen seroconversion. The mean peak alanine aminotransferase level was 3194.5±937.7 U/L. Entecavir was administered for an average of 39.8±10.5 days after the onset of the symptomatic hepatic dysfunction. Three patients who were experienced complications such as hepatic encephalopathy died. Only one patient survived liver failure. The median survival time after HBV reactivation and acute liver failure was 74.0 days (95% confidence interval, 31.9 to 116.1 days). The cumulative survival rate after HBV reactivation within three months was 25%. Conclusion: Prophylactic anti-HBV medication is recommended for HBV carriers with autoimmune diseases who are prescribed immunomodulatory agents for preventing catastrophic consequences such as acute liver failure caused by HBV reactivation.

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Hepatitis B Virus (HBV) and Autoimmune Disease

Cited by 110 publications

References 93 publications

Influence of genes, sex, age and environment on the onset of autoimmune hepatitis

Influence of genes, sex, age and environment on the onset of autoimmune hepatitis

High Level of Rheumatoid Factor is Associated with Hepatitis B Viremia in Patients with Chronic Hepatitis B

Acute Hepatic Failure Caused by Hepatitis B Virus Reactivation in Patients Receiving Immunomodulatory Agents for Autoimmune Diseases

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