Hepatitis B vaccinees may be mistaken for confirmed hepatitis B surface antigen‐positive blood donors

Dow, B. C.; Yates, P.; Galea, George; Munro, H.; Buchanan, Ian; Ferguson, Kristi J.

doi:10.1046/j.0042-9007.2001.00125.x

Cited by 28 publications

(23 citation statements)

References 3 publications

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“…(11) Another study on blood donors by Dow BC et al also disclosed that HBsAg disappeared five days post vaccination. (12) However, some studies are in contrast with the current study findings of HBsAg positivity turning negative one week post vaccination. This might be as previous studies were conducted on hemodialysis patients and healthy infants.…”

Section: Resultscontrasting

confidence: 54%

“…Another aspect of study by Dow BC et al was that different immunoassay methods were utilized for HBsAg, they inferred that antigen reactivity depends on the diagnostic assay used. (12) Zaiee M et al in a clinical trial among healthy adults has also postulated that HBsAg positivity depends on the type of vaccine and the diagnostic testing technique. (17) On the contrary, Otag F in a clinical trial with different brands of Hepatitis B vaccine deduced that vaccine induced antigenemia could be a possibility with any kind of HBV administered.…”

Section: Resultsmentioning

confidence: 99%

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False Positive Hepatitis B Surface Antigen Due to Recent Vaccination

Anjum¹

2014

IJHS

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Abstract:Objective: Hepatitis B is the most common viral hepatitis, potentially life threatening, with long term complications. Currently, vaccine is the most effective tool against hepatitis B infection. It is worthwhile mentioning that due to rampant use of hepatitis B vaccine (HBV), there have been concerns about hepatitis B surface antigen (HBsAg) reactivity. This article aims to report the false positive results of HBsAg due to recent HBV among healthy male adults. Subjects and Methods:The subjects were selected from a Community Health Center, under the umbrella of a tertiary care hospital, Saudi Arabia. The data was retrieved from electronic medical records maintained at the clinic. Results:A total of 130 employees were recruited, only 117 records could be retrieved from the system. The mean age of participants was 31.34 + 12.73 years. The administration of HBV and HBsAg test was performed simultaneously. The lab reported three cases of HBsAg positivity, a false positive result of 2.56%. Repeat testing after one week for HBsAg was negative for the three cases. Conclusion:This study confirmed that HBsAg reactivity might be seen in regular screening programs for healthy adults.

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Section: Resultscontrasting

confidence: 54%

Section: Resultsmentioning

confidence: 99%

False Positive Hepatitis B Surface Antigen Due to Recent Vaccination

Anjum¹

2014

IJHS

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“…Other possible causes include problems with equipment and vaccination against infl uenza or rabies, as well as the presence of heterophile antibodies (34) . Another known cause of false-positive results is immunization against hepatitis B. HBsAg may be detected right after vaccination, which is why it is recommended to avoid donating blood for up to 7 days after vaccination (35) . An additional well-recognized cause of false-positive results is pregnancy, where more than 50% of discrepant results are false positive (36) .…”

Section: Discussionmentioning

confidence: 99%

Clinical and epidemiological profile of female blood donors with positive serology for viral hepatitis B

Narciso-Schiavon

Schiavon

Carvalho-Filho

et al. 2015

Rev. Soc. Bras. Med. Trop.

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“…One of the 6.38% VRP tested within one month of HBV vaccination had both HBsAg and HBsAb detected in her, showing evidence of humoral response to HBV vaccine and gradual disappearance of HBsAg. Different authors have discovered and published the possibility of mistaking VRP for confirmed HBsAgpositive blood donors especially in recently vaccinated subjects [37,[44][45] . The ideal time to perform HBsAb screening in VRP should be 2-3 months after receiving the last dose of the vaccine [39] .…”

Section: Discussionmentioning

confidence: 99%

Hepatitis B Vaccination Outcomes and Broad Spectrum of Hepatitis B Infections in Nigeria: An Evidence-Based Picture

Kolawole¹,

Od²

2017

Am. J. Biomed. Sci.

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Background: Current evidence-based data on Hepatitis B vaccination coverage and outcomes in Nigeria are limited and these raise serious concern among stakeholders in clinical settings with respect to prevention of hepatitis B and safety of transfusion recipients. This study evaluated hepatitis B vaccination coverage and outcomes among apparently healthy blood donors in Ekiti State, Nigeria. Methods: Hepatitis B viral markers, including hepatitis B surface antibody (HBsAb), were serologically screened in four hundred and seventy prospective blood donors using NOVA 5-in-1 HBV rapid one-step multi-test kit and the results were interpreted using descriptive statistics of SPSS version 21. Results: Out of the four hundred and seventy (470) blood donors screened, 85 (18.1%) and 385 (81.9%) were vaccinated research participants and unvaccinated research participants (VRP and UVRP) respectively. Male: Female ratio and mean age (±SD) of VRP were 1:1 and 26.5 ± 6.8 while those of the UVRP were 1.6:1 and 26.9 ± 7.7. Evidence of successful vaccination was observed in 2.55% and 4.68% of VRP and UVRP respectively. Broad spectrum HBV infection totaling 11.05% based HBV markers seroprevalence was observed among the UVRP compared to the VRP with 0.85% seroprevalence. Conclusion: Low hepatitis B vaccine coverage among blood donors poses serious threats to public health including recipients of blood transfusion and hepatitis B vaccination programme should be re-strategized to cover the grass roots. Low HBV infection among the vaccinated research participants compared to the unvaccinated group showed long-term protection despite HBsAb loss. Post-vaccination testing is recommended for specific categories of individuals.

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Hepatitis B vaccinees may be mistaken for confirmed hepatitis B surface antigen‐positive blood donors

Abstract: The Abbott/Murex GE 34/36 assay demonstrated HBsAg reactivity in most volunteers on day 3 and in some on day 5 after vaccination. It is therefore recommended that individuals who have recently been vaccinated with hepatitis B be deferred from blood donation for at least 7 days.

Cited by 28 publications

References 3 publications

False Positive Hepatitis B Surface Antigen Due to Recent Vaccination

False Positive Hepatitis B Surface Antigen Due to Recent Vaccination

Clinical and epidemiological profile of female blood donors with positive serology for viral hepatitis B

Hepatitis B Vaccination Outcomes and Broad Spectrum of Hepatitis B Infections in Nigeria: An Evidence-Based Picture

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