Hepatitis B vaccine and the need for a booster dose after primary vaccination

Pileggi, Claudia; Papadopoli, Rosa; Bianco, Aida; Pavia, Marco

doi:10.1016/j.vaccine.2017.09.076

Cited by 40 publications

(38 citation statements)

References 36 publications

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“…Furthermore, in our study, the percentage of students with titers <10 mIU/mL was relatively higher than that found in other studies that evaluated medical students in Italy (40.8%, 29.3%, 12%, 15.8%) and lower with respect to that in other countries (72.4% in Malaysia, 59% in Israel) [22][23][24][25][26].…”

Section: Discussioncontrasting

confidence: 89%

Kinetics of Anti-Hepatitis B Surface Antigen Titers in Nurse Students after a Two-Year Follow-Up

et al. 2020

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Infection caused by hepatitis B virus (HBV) can be prevented through a safe and effective vaccine. This study analysed the kinetics of serum antibodies against hepatitis B surface antigen (HBsAg) (anti-HBs) titers in relation to previous vaccine boosters in Italian nursing students who were followed up for two years. Serum anti-HBs titers were evaluated at the first visit, after vaccine booster (if required) and at visit after two years. Overall, 483 students (mean age = 21.7 years; SD = 3.7) with median anti-HBs IgG titer of 6 mUI/mL (interquartile range (IQR) = 0–34) were enrolled. A total of 254 (52.5%) students with a titer lower than 10 mIU/mL were offered an anti-HBV booster at the first visit. Among these students, an exponential relation between anti-HBs IgG titer, one month after HBV booster and anti-HBs IgG titer two years later was found (y = 3.32 exp (0.0045x); R2 = 0.48; p < 0.001). Students with anti-HBV titer higher than 10 mIU/mL (N = 229) were followed up, and anti-HBs IgG titers at follow-up visit linearly correlated with anti-HBV baseline titers (y = 0.86x + 26.2; R2 = 0.67; p < 0.001). A decrease in anti-HBs titers can be expected a few years after the anti-HBV booster dose. This reduction is more pronounced than that observed in students not administered the booster dose and is exponential with respect to basal titers assessed after the booster dose.

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Section: Discussioncontrasting

confidence: 89%

Kinetics of Anti-Hepatitis B Surface Antigen Titers in Nurse Students after a Two-Year Follow-Up

et al. 2020

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“…Similarly to other studies [3, 26, 27], the 27.4% of subjects vaccinated during infancy also had an undetectable anti-HBs concentration and a GMC before booster dose of 11.1 mIU/mL.…”

Section: Discussionsupporting

confidence: 78%

Long-term persistency of hepatitis B immunity: an observational cross-sectional study on medical students and resident doctors

Stefanati

Bolognesi

Sandri

et al. 2019

Journal of Preventive Medicine and Hygiene

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“…Antibody titers are closely correlated with vaccine effectiveness. Nanovaccines have been shown to induce high antibody titers [ [102] , [103] , [104] , [105] ], probably due to their superiority in target delivery and DC activation as well as the capacity to carry large amounts of antigens [ 106 ]. Nanovaccines can be constructed to carry large quantities of peptides or protein antigens; this provides a high concentration of antigens for efficient B cell receptor (BCR) signaling, consequently improving the B cell response and antibody production ( Fig.…”

Section: Nano-based Vaccinesmentioning

confidence: 99%