Hepatitis B screening practices and viral control among persons living with HIV in urban Senegal

Ramírez-Mena, Adrià; Tine, Judicaël; Fortes, Louise; Ndiaye, O.; Kà, Daye; Ngom, Ndeye Fatou; Ramette, Alban; Bittel, Pascal; Seydi, Moussa; Wandeler, Gilles

doi:10.1111/jvh.13615

Cited by 3 publications

(1 citation statement)

References 30 publications

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“…SMIT and CTA are the largest referral centers for HIV care in Senegal, with >3000 people living with HIV (pwHIV) under regular follow-up. We also undertook the systematic HBsAg screening for all of the pwHIV in current follow-up at the SMIT/CTA clinics, and included individuals with HIV/HBV co-infection into SEN-B [ 12 ]. The SEN-B cohort was approved by the national Ethics Committee, and all of the patients signed an informed consent to participate in the study.…”

Section: Methodsmentioning

confidence: 99%

Prevalence and Predictors of Liver Fibrosis in People Living with Hepatitis B in Senegal

Mena

Ngom

Tine

et al. 2022

Viruses

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Hepatitis B virus (HBV) infection is the first cause of liver cirrhosis and cancer in West Africa. Although the exposure to additional environmental and infectious risk factors may lead to the faster progression of liver disease, few large-scale studies have evaluated the determinants of HBV-related liver fibrosis in the region. We used transient elastography to evaluate the prevalence of liver fibrosis and assessed the association between HBV markers and significant liver fibrosis in a cohort of people living with HBV in Dakar, Senegal. The prevalence of significant liver fibrosis was 12.5% (95% confidence interval [CI] 9.6%–15.9%) among 471 people with HBV mono-infection (pwHBV) and 6.4% (95% CI 2.6%–12.7%) in 110 people with HIV/HBV co-infection (pwHIV/HBV) on tenofovir-containing antiretroviral therapy (p = 0.07). An HBV viral load > 2000 IU/mL was found in 133 (28.3%) pwHBV and 5 (4.7%) pwHIV/HBV, and was associated with significant liver fibrosis (adjusted odds ratio (aOR) 1.95, 95% CI 1.04–3.66). Male participants (aOR 4.32, 95% CI 2.01–8.96) and those with elevated ALT (aOR 4.32, 95% CI 2.01–8.96) were especially at risk of having significant liver fibrosis. Our study shows that people with an HBV viral load above 2000 IU/mL have a two-fold increase in the risk of liver fibrosis and may have to be considered for antiviral therapy, independent of other disease parameters.

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Section: Methodsmentioning

confidence: 99%

Prevalence and Predictors of Liver Fibrosis in People Living with Hepatitis B in Senegal

Mena

Ngom

Tine

et al. 2022

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Liver Disease and Treatment Needs of Asymptomatic Persons Living With Hepatitis B in Senegal

Mena

Thioubou

Diallo

et al. 2022

Open Forum Infectious Diseases

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