Hepatitis B: From Blumberg to Bangladesh

Rahman, Salimur

doi:10.5005/jp-journals-10018-1010

Cited by 2 publications

(1 citation statement)

References 2 publications

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“…As found in our study, the prevalence of HBsAg was 68.4 % (Table 1) in patients; who had unprotected sex and 71.4% in patients with multiple sexual partners. Commencement of HBV infection due to mass illiteracy with sexual mal practice is indeed a global consequence as has been found in the our study [1,9,10,16,21,22,23,24,25,26,27]. Establishment of regulatory bodies with routine monitoring of the frequency of sexually transmitted diseases (STDs) thus may aid to predict on the probability of HBV infection instigation.…”

Section: Socio-demographic Characteristics and Behavioral Risk Factorsupporting

confidence: 58%

Study of Risk Factors Related to HBsAg Reactivity among Outdoor Patients in Dhaka Medical College and Hospital, Bangladesh

Uddin¹

2014

AJBLS

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Current investigation attempted to uncover common risk factors associated with HBsAg positivity among the suspected patients of Hepatitis B viral infection. Blood specimens were collected from patients prescribed to undergo HBsAg positivity test and tested for the detection of HBsAg through enzyme-linked immunosorbent assay (ELISA). HBsAg positivity was analyzed in relation to age, family history of HBV infection, unprotected sex, multiple sexual partners, blood transfusions, frequency of needle pricks, intravenous drug addiction, dental surgery and other surgical operations of the patients. Out of 50 patients, 23 were found to be HBsAg positive. After statistical analysis of all the factors it was deduced that patients who had unprotected sex and whose families (especially the mother of the patient) had a history of HBV infection were mostly found to be HBsAg positive. Detection of HBsAg positive cases with multiple associated risk factors revealed that the general people in Bangladesh need to be more conscious on the possible infection aware of getting infected with HBV as they are being frequently exposed subjected to the risk factors.

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Section: Socio-demographic Characteristics and Behavioral Risk Factorsupporting

confidence: 58%

Study of Risk Factors Related to HBsAg Reactivity among Outdoor Patients in Dhaka Medical College and Hospital, Bangladesh

Uddin¹

2014

AJBLS

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Evaluation of Chitinase 3-like 1 (CHI3L1) as a noninvasive biomarker of hepatic fibrosis in patients with Hepatitis B virus–related compensated chronic liver disease

Das

Kamrul-Hasan

Kabir

et al. 2021

Journal of Family Medicine and Primary Care

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Background: Liver biopsy is the gold-standard method for diagnosing and staging liver fibrosis, but the procedure is invasive, not available in the primary health care facilities, and not free from complications. Noninvasive serum biomarkers of hepatic fibrosis are the current research focus. Objectives: To assess the correlation between serum Chitinase 3-like 1 (CHI3L1) levels and histological severity in patients with Hepatitis B Virus (HBV)-related compensated chronic liver disease (CLD). Material and Methods: This cross-sectional study evaluated 50 treatment-naïve patients with chronic hepatitis B with compensated CLD. Liver biopsy was done, and hepatic fibrosis was categorized using the METAVIR scoring system; we divided the study subjects into three groups; group 1 included subjects with F0 and F1, group 2 having F2 group 3 having F3 and F4. Serum CHI3L1 was measured in all by immunoassay. Result: Among 50 patients, only one had METAVIR score F0, seven had F1, 33 had F2, nine had F3, and none had METAVIR score F4. The median value of CHI3L1 was 460.8 (IQR 340.1-570.3) in all study subjects; 359.5 (IQR 272.8-526.9) in group 1, 450.0 (IQR 307.75-5332.0) in group 2, and 1355.5 (IQR 530.75-1580.5) in the group 3. The difference in median CHI3L1 across the groups was statistically significant. Serum aspartate aminotransferase (AST) and the AST to Platelet Ratio Index (APRI) score had significant positive correlations with CHI3L1 levels. CHI3L1 also had significant positive correlations with METAVIR scores. Conclusion: This study found a positive correlation between serum CHI3L1 level and hepatic histological severity in patients with HBV-related compensated CLD. Further larger-scale research is needed to establish the fact.

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Hepatitis B: From Blumberg to Bangladesh

Cited by 2 publications

References 2 publications

Study of Risk Factors Related to HBsAg Reactivity among Outdoor Patients in Dhaka Medical College and Hospital, Bangladesh

Study of Risk Factors Related to HBsAg Reactivity among Outdoor Patients in Dhaka Medical College and Hospital, Bangladesh

Evaluation of Chitinase 3-like 1 (CHI3L1) as a noninvasive biomarker of hepatic fibrosis in patients with Hepatitis B virus–related compensated chronic liver disease

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