Evaluation of Chitinase 3-like 1 (CHI3L1) as a noninvasive biomarker of hepatic fibrosis in patients with Hepatitis B virus–related compensated chronic liver disease

Das, Amit; Kamrul-Hasan, A B; Kabir, Mohammed Ruhul; Das, Sutapa; Zaki, Kmj; Mahtab, Mamun Al

doi:10.4103/jfmpc.jfmpc_1922_20

Cited by 5 publications

(2 citation statements)

References 21 publications

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“…Viral, bacterial, and parasitic infections, improper diet, alcohol consumption, stones, and other diseases can cause lesions in the liver, leading to different types of liver diseases. Many scholars have already discovered changes in the content of CHI3L1 in liver injury, liver cancer, liver fibrosis, cirrhosis, and other diseases [83][84][85][86][87][88][89].…”

Section: Correlation Between Chi3l1 and Liver Diseasesmentioning

confidence: 99%

Potential Roles and Future Perspectives of Chitinase 3-like 1 in Macrophage Polarization and the Development of Diseases

Zhao,

Huang,

Jiang

2023

IJMS

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Chitinase-3-like protein 1 (CHI3L1), a chitinase-like protein family member, is a secreted glycoprotein that mediates macrophage polarization, inflammation, apoptosis, angiogenesis, and carcinogenesis. Abnormal CHI3L1 expression has been associated with multiple metabolic and neurological disorders, including diabetes, atherosclerosis, and Alzheimer’s disease. Aberrant CHI3L1 expression is also reportedly associated with tumor migration and metastasis, as well as contributions to immune escape, playing important roles in tumor progression. However, the physiological and pathophysiological roles of CHI3L1 in the development of metabolic and neurodegenerative diseases and cancer remain unclear. Understanding the polarization relationship between CHI3L1 and macrophages is crucial for disease progression. Recent research has uncovered the complex mechanisms of CHI3L1 in different diseases, highlighting its close association with macrophage functional polarization. In this article, we review recent findings regarding the various disease types and summarize the relationship between macrophages and CHI3L1. Furthermore, this article also provides a brief overview of the various mechanisms and inhibitors employed to inhibit CHI3L1 and disrupt its interaction with receptors. These endeavors highlight the pivotal roles of CHI3L1 and suggest therapeutic approaches targeting CHI3L1 in the development of metabolic diseases, neurodegenerative diseases, and cancers.

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Section: Correlation Between Chi3l1 and Liver Diseasesmentioning

confidence: 99%

Potential Roles and Future Perspectives of Chitinase 3-like 1 in Macrophage Polarization and the Development of Diseases

Zhao,

Huang,

Jiang

2023

IJMS

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“…Drug-induced hepatotoxicity, Steatohepatitis, immunological liver disorders, chronic liver infections, alcohol dependence, and schistosomiasis are all etiological factors associated with the progression of liver fibrosis. The prevalence of liver fibrosis is primarily attributed to chronic infection with hepatitis viruses, which stands as the most prevalent identified risk factor [2]. The accumulation of extracellular matrix proteins is a consequence of chronic liver injury, leading to the degradation of the hepatic structure.…”

Section: Introductionmentioning

confidence: 99%

Assessment of Tissue inhibitor of metalloproteinase-1 and many biochemical parameters in patients with chronic hepatitis B in Tikrit city

Abdulla

2023

wjps

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Abstract— The main objective of this cross-sectional investigation was to assess biomarkers associated with liver fibrosis, namely Tissue inhibitor of metalloproteinase 1 TIMP-1, Glutamate-pyruvic transaminase GPT, glutamic-oxaloacetic transaminase GOT, and Alkaline phosphatase ALP. which conduct in Tikrit University, College of Science /Biology Department the study samples collected from patients in Dialysis Unit in Tikrit Teaching Hospital, ninty subjects where sub-divided to 60 patients of age (20– 68) years, the Ages of Patients Chronic hepatitis B Ranged From (20-67) years( 19 males and 11 females ) And The Ages Of Patients with chronic hepatitis B suffered of chronic kidney diseases (24-68) Years ( 18males and 12 females) and 30 as control group aged (20-67) years, in this investigation Enzyme linked immunosorbent assay (ELISA) kites were employed to assess serum concentrations of (TIMP-1), Whereas used Monarch-240 to detect the activity of enzymes such as GPT, GOT and ALP. The findings of the present investigation demonstrated in chronic hepatitis patients there were significant increased (P≤0.05) in the levels of TIMP-1, and activity of GPT and ALP whereas no significant rise (P≥0.05) for activity of GOT when compared with control. In patients with chronic hepatitis B (CHB) suffered of chronic kidney diseases(CKD) there were significant raised (P<0.05) in the levelsTIMP-1, ALT and ALP while no significant rised (P≥0.05) in levels of AST when compared with control. Current data suggest that TIMP-1 can be a promising biomarker of active fibrogenesis, after HBV chronic infection.

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Diagnostic Value of Serum Chitinase-3-Like Protein 1 for Liver Fibrosis: A Meta-analysis

Huang

Zhuang

Yang

et al. 2022

BioMed Research International

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Background. Serum chitinase-3-like protein 1 (CHI3L1) is a promising marker for diagnosing liver fibrosis. This meta-analysis was carried out to assess the diagnostic performance of serum CHI3L1 for the estimation of liver fibrosis. Methods. Systematic searches were performed on PubMed, Embase, Web of Science, Scopus, the Cochrane Library, Google Scholar, Sinomed, the China National Knowledge Infrastructure (CNKI), the Chinese Medical Journal Database, and the Wanfang databases for available studies. The primary studies were screened strictly according to inclusion and exclusion criteria, and sensitivity, specificity, and other measures of accuracy of serum CHI3L1 for evaluating liver fibrosis were pooled with 95% confidence intervals. I 2 was calculated to assess heterogeneity, and sources of heterogeneity were explored by subgroup analysis. Deeks’ test was used to assess for publication bias, and likelihood ratio was used to determine posttest probability. Results. Our research integrated 11 articles, accounting for 1897 patients older than 18 years old. The pooled sensitivity and specificity for significant fibrosis, advanced fibrosis, and cirrhosis were 0.79 and 0.82 with an area under the receiver operating characteristic curve (AUC) of 0.85, 0.81 and 0.83 with an AUC of 0.91, and 0.72 and 0.74 with an AUC of 0.85, respectively. Random-effects models were used to assess for significant heterogeneity, and subgroup analysis showed that age and aetiology of included patients were likely sources of heterogeneity. No potential publication bias was found for serum CHI3L1 in the diagnosis of significant fibrosis, advanced fibrosis, or cirrhosis, and posttest probability was moderate. Conclusion. Measurement of serum CHI3L1 is a feasible diagnostic tool for liver fibrosis.

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Evaluation of Chitinase 3-like 1 (CHI3L1) as a noninvasive biomarker of hepatic fibrosis in patients with Hepatitis B virus–related compensated chronic liver disease

Cited by 5 publications

References 21 publications

Potential Roles and Future Perspectives of Chitinase 3-like 1 in Macrophage Polarization and the Development of Diseases

Potential Roles and Future Perspectives of Chitinase 3-like 1 in Macrophage Polarization and the Development of Diseases

Assessment of Tissue inhibitor of metalloproteinase-1 and many biochemical parameters in patients with chronic hepatitis B in Tikrit city

Diagnostic Value of Serum Chitinase-3-Like Protein 1 for Liver Fibrosis: A Meta-analysis

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