Hepatitis associated with captopril treatment.

Vandenburg, M. J.; Parfrey, Patrick S.; Wright, P; Lazda, Edgar Janis

doi:10.1111/j.1365-2125.1981.tb01116.x

Cited by 21 publications

(2 citation statements)

References 1 publication

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“…After the first report of hepatotoxicity following treatment with captopril [27] there have been several additional reports with captopril [1,6,10,18,19,21,24,28] as well as with enalapril [12,15,17,20,26] and other ACE inhibitors [4,13]. Most of the patients in these reports were receiving other medication concurrently, though these medications are not commonly associated with hepatotoxicity.…”

Section: Angiotensin-converting-enzyme (Ace) Inhibitors and Hepatotoxmentioning

confidence: 99%

Acute Liver Failure due to Enalapril

Jeserich

Ihling²,

Allgaier³

et al. 2000

Herz

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This report presents a 46-year-old man who was treated for hypertension with the angiotensin-converting-enzyme (ACE) inhibitor enalapril. After 3 years of continuous treatment he presented with jaundice and progressive liver failure that continued despite withdrawal of the medication. The patient was taking no other medication. All known causes of acute liver failure could be excluded indicating a drug-induced liver damage after long-term treatment with enalapril. Analysis of liver biopsies revealed a pathomorphological pattern comparable to than observed in severe halothane hepatitis. Serological studies including T-cell stimulation with enalapril and a broad spectrum of tests for autoimmunity including autoantibodies against calreticulin, the major Ca2+ and Zn2+ binding protein of the endoplasmic reticulum and suggested to be involved in the pathogenesis of halothane hepatitis were negative. Thus, the mechanism of enalapril-induced liver injury remains obscure. Liver failure progressed and finally led to orthotopic liver transplantation. To our knowledge, this is the longest duration of chronic treatment with an ACE inhibitor before liver failure occurred. In addition, liver failure progressed despite withdrawal of the medication. It is concluded that even after long-term treatment with an ACE inhibitor liver failure may be induced. Therefore, regular monitoring of liver enzymes should be considered.

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Section: Angiotensin-converting-enzyme (Ace) Inhibitors and Hepatotoxmentioning

confidence: 99%

Acute Liver Failure due to Enalapril

Jeserich

Ihling²,

Allgaier³

et al. 2000

Herz

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“…Its adverse effects include agranulocytosis in 0 3%, proteinuria in 1-2%, and pruritus or dermatitis in 7 % of patients.1 Although mild increases in liver enzyme activities have been noted in a few patients,2 hepatitis is not a recognised complication of treatment with captopril and has been reported in only one patient. 3 Case report A 74 year old woman was admitted to hospital on 12 December 1982 for severe left and right sided heart failure. She had a five year history of ischaemic heart disease, including two episodes of myocardial infarction, and a pacemaker had been implanted for complete atrioventricular block.…”

Section: Commentmentioning

confidence: 99%

Moulded baby syndrome and unilateral "tight" hips.

Good¹,

Walker²

1983

BMJ

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The construction of biochemical reference ranges and the identification of possible adverse drug reactions in the elderly

Lawrence¹,

Trewin²

1991

Statistics in Medicine

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In the assessment of adverse drug reactions (ADRs) it is important to establish what is a normal range of values for a given biochemical measurement. Furthermore, such ranges need to be specific to the study population, for example, the elderly. A mixture of Gaussian distributions has been used in the construction of the reference ranges with maximum likelihood used to obtain estimates of the unknown parameters. With this approach, well-defined reference ranges have been established. Brief details are given of the numbers of ADRs identified in the study population using these ranges.

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Hepatitis associated with captopril treatment.

Cited by 21 publications

References 1 publication

Acute Liver Failure due to Enalapril

Acute Liver Failure due to Enalapril

Moulded baby syndrome and unilateral "tight" hips.

The construction of biochemical reference ranges and the identification of possible adverse drug reactions in the elderly

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