Hepatitis aguda tras ingestión de té verde

Martínez‐Sierra, Carmen; Unceta, Paloma Rendón; Herrera, L. Martín

doi:10.1157/13090268

Cited by 17 publications

(3 citation statements)

References 5 publications

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“…After halting consumption of the beverage the symptoms disappeared but reappeared after re-exposure. The authors point out that pulegon contained in mint leaves is also hepatotoxic but that they ascribe the liver damage observed here to the green tea portion in the starting material of the beverage (Martinez-Sierra et al, 2006).…”

Section: Afssaps (Agencementioning

confidence: 78%

ESCO report: Advice on the EFSA guidance document for the safety assessment of botanicals and botanical preparations intended for use as food supplements, based on real case studies

Dusemund¹

2009

EFS3

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SUMMARYIn June 2008, after an initial public consultation, the Scientific Committee of EFSA published a guidance document for the safety assessment of botanicals and botanical preparations intended for use as ingredients in food supplements. Recommendation was made at the same time to test the proposed approach for safety assessment with a number of examples, and consider amending the Compendia i) of botanicals reported to contain toxic, addictive or psychotropic substances and ii) of botanicals reported to have also a medicinal use.An EFSA Scientific Cooperation (ESCO) Working Group composed of experts identified by the members of the Advisory Forum, and by the Scientific Committee was created to fulfill this request, and advise on the adequacy of the proposed approach for the safety assessment of botanicals and botanical preparations for EFSA and the European Member States" needs. In addition the Working Group was asked to update the Compendia.The ESCO Working Group considered six botanical preparations to test the science-based framework described the guidance document: i) hydroalcoholic extract of dried peel of Citrus aurantium L. ssp. aurantium L., ii) dried green tea extract of Camellia sinensis (L.) Kuntze, iii) dried leaves extract of Ocimum tenuiflorum L., iv) dried fruits water extract of Foeniculum vulgare Mill. ssp. vulgare var. vulgare, v) dried ripe seeds of Linum usitatissimum L., and vi) wheat bran from Triticum aestivum L. These examples were selected in order to address various safety issues, such as misidentification / adulteration, liver toxicity, possible presence of genotoxic and carcinogenic compounds. Based on the experience acquired through the examples, the ESCO Working Group identified a number of possible amendments and additions for the guidance document of the Scientific Committee.

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Section: Afssaps (Agencementioning

confidence: 78%

ESCO report: Advice on the EFSA guidance document for the safety assessment of botanicals and botanical preparations intended for use as food supplements, based on real case studies

Dusemund¹

2009

EFS3

View full text Add to dashboard Cite

show abstract

“…En cuanto a las sustancias implicadas en reacciones adversas hepáticas de la presente serie, algunas han sido ampliamente relacionadas con este tipo de enfermedad. Hasta 2007 han sido publicados más de 30 casos de hepatotoxicidad secundaria a té verde (Camellia Sinensis) ingeridos con fines adelgazantes, uno de ellos perteneciente al presente estudio (11,(31)(32)(33)(34)(35)(36)(37)(38)(39)(40)(41)(42)(43). Es más, una especialidad farmacéutica que contenía el extracto etanólico de esta sustancia, Exolise ® , fue retirada del mercado por la Agencia Española del Medicamento y productos farmacéuticos en abril de 2003 debido a la notificación de 4 casos a la Agencia Española de Farmacovigilancia y 9 casos notificados en Francia (44).…”

Section: Resultsunclassified

“…Comúnmente se ha atribuido hepatotoxicidad a su extracto etanólico y en menor medida a la «camilina» o polvo de hojas de té trituradas (Arkocapsulas ® ). Sin embargo, desde su retirada, se han seguido comunicando casos de daño hepático secundario a otras formas de Camellia sinensis como las infusiones (33,34).…”

Section: Resultsunclassified