Hepatitis A viral genotypes and clinical relevance: Clinical and molecular characterization of hepatitis A virus isolates from northern India

Hussain, Zahid; Das, Bhudev C.; Husain, Syed Akhtar; Asim, Mohammad; Chattopadhyay, Saket; Malik, Abdul; Poovorawan, Yong; Theamboonlers, Apiradee; Kar, Premashis

doi:10.1016/j.hepres.2005.01.014

Cited by 40 publications

(42 citation statements)

References 29 publications

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“…non coding region (5 0 NCR), as described previously [7]. For conventional PCR, a set of primers were used to amplify the VP1/2A junction (168 pb) [15,21,31]. RTPCRs were carried out using a Qiagen OneStep RT-PCR kit (Qiagen, hilden, germany) according to the manufacturer's instructions.…”

Section: Serological Proceduresmentioning

confidence: 99%

Seroprevalence and Molecular Characterisation of Human Hepatitis A virus in Serum Samples of Tunisian Patients with Clinical Symptoms of Viral Hepatitis

et al. 2012

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The aim of the present study was to investigate the seroprevalence of Hepatitis A virus antibodies in patients with clinical symptoms of viral hepatitis and molecular characterization of the detected isolates. The present study deals with the seroprevalence and the genetic diversity of HAV in 400 Tunisian patients presenting in dispensaries (160 patients) and in University Hospitals (240 patients) with hepatitis symptoms between 2006 and 2008. The patients with acute hepatitis were mainly from rural regions. However, the total number of patients was decreased over time. The collected samples were from patients with hepatitis symptoms occurring mainly during January-March (36.7, 26, and 35.5%) and SeptemberDecember (39.4, 43.4,and 35.5%) during the three years of study, respectively. However, HAV infection was established for only 110 among 400 patients. The detected isolates were clustered within sub-genotype IA. The present study constituted another report of the continued surveillance of HAV infection in the region of Monastir and the molecular characterisation of the detected strains.

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Section: Serological Proceduresmentioning

confidence: 99%

Seroprevalence and Molecular Characterisation of Human Hepatitis A virus in Serum Samples of Tunisian Patients with Clinical Symptoms of Viral Hepatitis

et al. 2012

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“…A study conducted in the Northern part of India in 2002-2003 revealed cocirculation of HAV subgenotype IA and IIIA. 23 Our research area, the Vanni region, is separated from south India by a very narrow stretch of sea called Palk Strait. As there is frequent illegal traveling between Sri Lanka and India, there can be similarities in circulating genotypes of HAV in these two countries, as observed here.…”

Section: Resultsmentioning

confidence: 99%

Clinical Features and Transmission Pattern of Hepatitis A: An Experience from a Hepatitis A Outbreak Caused by Two Cocirculating Genotypes in Sri Lanka

Dahanayaka

Kiyohara

Agampodi

et al. 2016

The American Journal of Tropical Medicine and Hygiene

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Abstract. Sri Lanka is one of the intermediate-endemic areas for hepatitis A virus (HAV), and concerns exist about the increasing HAV-susceptible population. In fact, Sri Lanka recorded a large hepatitis outbreak, possibly hepatitis A, around the end of the Sri Lankan war. It included more than 14,000 patients consisting of local residents, internally displaced personnel, and military personnel in the main combat zone. The outbreak had slowed down by October 2009; however, acute viral hepatitis continued to occur sequentially among military personnel. We obtained clinical information and serum samples from 222 patients with acute hepatitis who visited the Military Hospital Anuradhapura between January and September 2010. Samples were subjected to laboratory testing including HAV-immunoglobulin M and genotyping. Most patients (98.2%) were confirmed as having hepatitis A belonging to two subgenotypes: IA and IIIA. We did not observe any differences in clinical or biochemical features among patients with subgenotypes IA and IIIA except for pale stools and upper abdominal discomfort. During the investigation period, we observed a serial outbreak caused by identical HAV strains with an interval in line with that of typical HAV incubation periods. Most patients in the first outbreak were found in the training center, and patients in the second outbreak were found in multiple places where soldiers were assigned after the training center. These findings indicate that a strain of HAV diffused from one place to another along with movement of infected persons among the HAV-susceptible population. HAV vaccination for high-risk groups, such as young soldiers, is necessary.

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“…HEV isolates are divided into 4 genotypes and more than 24 subtypes [12]. HAV is divided into seven different genotypes (I-VII), which infect human (I-III) and simian (IV-V) [13]. HAV and HEV are an important public health concerns in Pakistan [14].…”

Section: Hepatitis E Virus (Hev) Infection Is Perhaps the Most Recurrmentioning

confidence: 99%

Frequency of hepatitis E and Hepatitis A virus in water sample collected from Faisalabad, Pakistan

Ahmad¹,

Anjum²,

Zaidi³

et al. 2015

Ann Agric Environ Med.

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Hepatitis E and Hepatitis A virus both are highly prevalent in Pakistan mainly present as a sporadic disease. The aim of the current study is to isolate and characterized the specific genotype of Hepatitis E virus from water bodies of Faisalabad, Pakistan. Drinking and sewage samples were qualitatively analyzed by using RT-PCR. HEV Genotype 1 strain was recovered from sewage water of Faisalabad. Prevalence of HEV and HAV in sewage water propose the possibility of gradual decline in the protection level of the circulated vaccine in the Pakistani population.

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Hepatitis A viral genotypes and clinical relevance: Clinical and molecular characterization of hepatitis A virus isolates from northern India

Cited by 40 publications

References 29 publications

Seroprevalence and Molecular Characterisation of Human Hepatitis A virus in Serum Samples of Tunisian Patients with Clinical Symptoms of Viral Hepatitis

Seroprevalence and Molecular Characterisation of Human Hepatitis A virus in Serum Samples of Tunisian Patients with Clinical Symptoms of Viral Hepatitis

Clinical Features and Transmission Pattern of Hepatitis A: An Experience from a Hepatitis A Outbreak Caused by Two Cocirculating Genotypes in Sri Lanka

Frequency of hepatitis E and Hepatitis A virus in water sample collected from Faisalabad, Pakistan

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