Hepatitis-a Antigen in Edinburgh

Hopkins, Robert; Scott, TA

doi:10.1016/s0140-6736(76)92386-2

Cited by 3 publications

(1 citation statement)

References 10 publications

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“…Antigen was found as early as 11 days before, and as late as 10 days after the onset of jaundice. In contrast, others, using immune electron microscopy, did not find shedding of antigen after the onset of illness (Hopkins and Scott, 1976;Flehmig et al, in preparation). However, infectivity of faeces collected after onset of jaundice has been demonstrated (Deinhardt et al, 1975;Krugman, Ward and Giles, 1962), and the Phoenix antigen, a pool of faeces collected between 3 and 10 days after onset of illness, contained 27 nm virus particles and caused infection in chimpanzees (Bradley et al, 1976).…”

Section: Discussionmentioning

confidence: 99%

Seroepidemiological investigation of patients and family contacts in an epidemic of hepatitis A

Frösner

Overby

Flehmig

et al. 1977

Journal of Medical Virology

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Serial blood and faecal samples were collected from patients and family contacts during an outbreak of hepatitis A in a village and tested by a solid-phase competitive type radioimmunoassay for hepatitis A antigen and hepatitis A antibody. The amount and duration of excretion of hepatitis A antigen was correlated with the severity of the illness. In 2 severe clinical cases, hepatitis A antigen was demonstrated in faecal extracts 11 days before the onset of jaundice and continuing for 10 days thereafter, with maximum shedding during the late incubation period. Faecal antigen was demonstrated in low concentrations for only 2 days in a patient with mild disease and in a person with subclinical infection. There was an inverse correlation between the incidence of infection and prevalence of hepatitis A antibody and age. Of 24 infections, 19 (79%) occurred in persons in the age group 0 to 20 years, a group in which only 6% of individuals had pre-existing antibody. Hepatitis A antibody was present in the serum of 3 persons in low titres of 1:20 to 1:40 on the day jaundice developed. The antibody titres increased very rapidly during the following 2 weeks of illness and slowly during the following months, reaching titres of 1:900 to 1:3500. In a separate study, a mean antibody titre of 1:591 was found in 13 patients, 12 years after clinical hepatitis A with jaundice.

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Section: Discussionmentioning

confidence: 99%

Seroepidemiological investigation of patients and family contacts in an epidemic of hepatitis A

Frösner

Overby

Flehmig

et al. 1977

Journal of Medical Virology

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Viruses of Human Hepatitis A and B

Robinson

1979

Comprehensive Virology

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Hepatitis A-virus particles in stools of patients from a natural hepatitis outbreak in Germany

Flehmig¹,

Hensel

Frösner

et al. 1977

Med Microbiol Immunol

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During a hepatitis outbreak in Southern Germany 27 nm particles were visualized by immune electron microscopy in stools of two patients. These particles were sereologically identical or similar to hepatitis A-virus particles identified in the USA. The buoyant density of these particles was 1.34 g/cm3 as shown by cesium chloride density centrifugation. The particles were first observed in small numbers in a stool obtained 11 days, and in large numbers in stools obtained 6 and 7 days before the onset of jaundice. Few particles were seen on the day of the onset of jaundice and none thereafter. In both patients a sereoconversion to hepatitis A-virus as judged by immune electron microscopy could be demonstrated.

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Hepatitis-a Antigen in Edinburgh

Cited by 3 publications

References 10 publications

Seroepidemiological investigation of patients and family contacts in an epidemic of hepatitis A

Seroepidemiological investigation of patients and family contacts in an epidemic of hepatitis A

Viruses of Human Hepatitis A and B

Hepatitis A-virus particles in stools of patients from a natural hepatitis outbreak in Germany

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