Hepatite B e a superinfecção por vírus D em pacientes crônicos na Amazônia ocidental brasileira

Abstract

Exceto onde especificado diferentemente, a matéria publicada neste periódico é licenciada sob forma de uma licença Creative Commons -Atribuição 4. Method:Descriptive study based on secondary data from medical records of 208 patients. These patients were divided into two (2) groups (HBV and HBV+HDV), followed in Hepatology Clinic from Sanitary Dermatology Hospital in Cruzeiro do Sul city, Acre state, a regional reference healthcenter. Results: 42.8% -of the 208 records analyzedhave presented HBV infection, and 57.2% were diagnosed with coinfection, ie. HBV+HDV, associated hepatitis viruses infection. Both patients group were predominantly male (67.4% = HBV, and 67.2% = HBV+HDV), aged between 12 and 31 years old. Regarding the analysis of clinical, serological, biochemical and hematological, an overview have showed that, the group with associated HBV+HDV infection presented a poorer prognosis compared to the group with HBV monoinfection. Conclusion: It is possible to assert that superinfection by HDV, in the western Brazilian Amazon, is a serious health problem. It is necessary to carry out studies, especially with clinical approach, concerning chronically ill patients. RESUMO ABSTRACT

Evidências científicas sobre a hepatite Delta no Brasil: revisão integrativa da literatura

“…(5) Furthermore, studies indicate that the HDV is related to the early development of serious conditions of hepatic diseases, such as: Cirrhosis, hepatocellular carcinoma (HCC) and fulminant hepatitis. (6,7) The hepatitis cases caused by HDV associated with HBV represent a serious worldwide public health problem, generating continuous demands to health services, in addition to considerable losses in the quality of life of infected patients, also showing high mortality rates. (8) This kind of infection is distributed around the globe; HBV, the required element for HDV infection, is estimated to have already infected 2 billion individuals worldwide, of which 300 to 400 million are chronic carriers and 15 to 20 million are infected with the HDV (2.9) , with an annual number of deaths estimated between 620,000 and 1 million.…”

Chronic hepatitis B and D: prognosis according to Child-Pugh score

“…Early evolution into the more severe complications of hepatic disease has been systematically related to HDV superinfection (7,(12)(13) . This represents a serious health problem in the context of the Brazilian Occidental Amazon, principally due to the relationship between the infection and exacerbation of symptoms (14) .…”

“…Thus, considering the elevated endemic pattern of HBV infection and HDV superinfection in the Brazilian Western Amazon, as well as the exacerbation of signs and symptoms and early evolution to final stages of HDV-related chronic hepatitis (12,21) , in addition to the scarcity of scientific studies realized in the Brazilian Western Amazon on this subject (14,22) , the present study aimed to compare patients with chronic hepatitis B and those superinfected with D-virus according to the Child-Pugh score for disease severity.…”