Hépatite B chronique: aspects épidémiologique, diagnostique, thérapeutique et évolutif au centre hospitalier universitaire Yalgado Ouédraogo de Ouagadougou

Sombié, Roger; Bougouma, A.; Diallo, O.; Bonkoungou, G.; Cissé, Rabiou; Sangaré, Lassana; Sia, Roberto L.; Serme, K.; Ilboudo, D.

doi:10.1007/s12157-009-0137-2

Cited by 18 publications

(32 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In literature, the occult hepatitis B viral infection prevalence varies according to the detection method and the endemic level of the area [5] [10]. Burkina Faso is a high endemic area for hepatitis B with a prevalence higher than 14% [8] [9].…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Hepatitis B Surface Antigen Should Not Be the Only Sought Marker to Distinguish Blood Donors towards Hepatitis B Virus Infection in High Prevalence Area

Somda¹,

Sermé²,

Coulibaly³

et al. 2016

OJGas

Self Cite

View full text Add to dashboard Cite

Since its discovery by Blumberg in 1965, the hepatitis B surface antigen (HBsAg) is used as the fingerprint of hepatitis B infection. Occult hepatitis B infection (OBI) is defined by a viral replication (DNA detectable) in the absence of HBsAg. Burkina Faso is a high endemic area where the prevalence is higher than 14%. At the National Center for Blood Transfusion (NCBT) of Ouagadougou, HBsAg is the only sought marker used to distinguish donors towards Hepatitis B Virus (HBV). Acceptation of blood donation is based specifically on the absence of HBsAg, which exposes to the risk of HBV transmission during transfusion. The goal of this study is to evaluate this risk by determining the prevalence of OBI in blood donors. Patients and Methods: It was a five-month prospective study on blood donations collected from January to May 2016. The HBc antibody has been sought in the serums of negative HBsAg donors. The measure of B DNA by Real Time PCR (polymerase chain reaction) and that of antibodies anti-HBs have been proposed to anti-HBc positive donors. Abdominal ultrasound, the transaminases, prothrombin level, alphafeto-proteins, hepatic fibrosis have been proposed to donors who were detectable for the DNA. Sociodemographic parameters have been collected. The test costs were borne by donors who were recalled by phone to adhere to the study. Results: Among 1980 negative donors HBsAg, 872 (44%) were positive for anti-HBc. 160 on 872 donors were received for consultation, among which 76 (76/160) were able to realise DNA which was detectable in 25 donors on 76, thus a prevalence of 32.8%. The mean value of DNA was 953 IU/ml. Physical examination and hepatic ultrasounds were normal except a case where hepatic steatosis was found. The biologic standard hepatic results were in normal range. None of the patient was able to realise hepatic fibrosis evaluation. A case of co-infection HIV/OBI was noted. Conclusion: This study shows that in BurHow to cite this paper: Somda, K.S., Sermé, A.K., Coulibaly, A., Cissé, K., Sawadogo, A., Sombié, A.R. and Bougouma, A. 363kina, almost half of blood bags transfused are anti-HBc positive and around one third (32.8%) probably have HBV DNA. This poses a potential risk of contamination for non-immunized recipient. It is thus important that, in addition to HBsAg, AntiHBc should be systematically sought in order to minimize the risk.

show abstract

Section: Discussionmentioning

confidence: 99%

“…Burkina Faso is a high endemic area where the prevalence of hepatitis B viral infection is higher than 14% [8] [9]. At the National Center for Blood Transfusion (NCBT) of Ouagadougou, HBsAg is the only sought marker used to distinguish donors towards hepatitis B viral (HBV) infection.…”

Section: Introductionmentioning

confidence: 99%

Hepatitis B Surface Antigen Should Not Be the Only Sought Marker to Distinguish Blood Donors towards Hepatitis B Virus Infection in High Prevalence Area

Somda¹,

Sermé²,

Coulibaly³

et al. 2016

OJGas

Self Cite

View full text Add to dashboard Cite

show abstract

“…The World Health Organization (WHO) estimates that about 2 billion people are infected with HBV worldwide and about 350 million of them suffer from chronic hepatitis B [1]. It is also estimated that about 65 million among all people chronically infected live in Africa [2] and that hepatitis B is responsible for the deaths from 500,000 to 1.2 million people each year [1].…”

Section: Introductionmentioning

confidence: 99%

“…It is also estimated that about 65 million among all people chronically infected live in Africa [2] and that hepatitis B is responsible for the deaths from 500,000 to 1.2 million people each year [1]. Overall, the impact of chronic liver disease (including HBV) is very important, and liver cancer is the third most common cause of cancer deaths worldwide [3].…”

Section: Introductionmentioning

confidence: 99%

“…In endemic areas, perinatal transmission is the main mode of HIV transmission: no vaccination or prophylaxis within 24 hours of birth, 70% to 90% of children born to positive mothers HBs antigen (HBsAg)-main marker chronic HBV infection are infected with HBV before the age of six months [1]. Studies also show that, if a young person is infected with HBV, the risk of developing chronic infection is high: it is estimated that 15% -25% of adults who contract chronic infection in childhood will die prematurely from liver complications, cirrhosis or liver cancer [4].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Prevention of Mother-to-Child Transmission of Hepatitis B in the Urban District Health Baskuy Burkina Faso

Guingané¹,

Méda²,

Sombié³

et al. 2016

OJGas

View full text Add to dashboard Cite

Few studies have been conducted on the epidemiology in pregnancy in sub-Saharan Africa. This study aimed to improve the care of pregnant women infected with hepatitis B virus (VHB) and their newborns in the urban district health. Method: This study was conducted from 01/09/2014 to 01/09/2015. Study involved three types of data collection: a collection of data from health facilities involved in the project; repeated cross-sectional survey among health personnel; a prospective study of pregnant women identified positive for HBsAg and followed at the University Hospital Yalgado Ouédraogo (CHU-YO). Knowledge assessment was made among health staff and pregnant women using a knowledge score. Construction of the score came after a factorial analysis of multiple correspondences on population health workers surveyed in the first round (N = 119) on one hand and all pregnant women (N = 266) on the other hand. This had identified among the 79/19 questions, those that discriminated best knowledge of paramedics and pregnant women. For pregnant women, this score was then dichotomized from the center and logistic regression was performed to determine the sociodemographic, medical and obstetric characteristics that influenced it (p value < 005). Results: Health staff had been surveyed twice (N = 119/100). In general, the level of knowledge was good on targeted knowledge, both before and after training. No health worker routinely offered screening for hepatitis B among pregnant women attending antenatal clinics. Altogether 266 pregnant women HBsAg-positive were referred and followed CHU-YO. Half of the patients had a score lower than 2/17. Univariate analysis showed that variables such as education level influenced significantly the level of knowledge. Women with

show abstract

Hépatite C chronique: épidémiologie, diagnostic et traitement au CHU Yalgado-Ouédraogo de Ouagadougou

Sombié

Bougouma

Somda

et al. 2010

J Afr Hepato Gastroenterol

Self Cite

View full text Add to dashboard Cite

Notre travail a pour but d'étudier les aspects épidé-miologique, diagnostique et thérapeutique de l'hépatite C chronique. Patients et méthodes : Il s'agit d'une étude clinique prospective réalisée, d'octobre 2005 à décembre 2009, dans le service d'hépatogastroentérologie. Ont été inclus les patients anti-virus de l'hépatite C (VHC) et ARN-VHC positifs. La quantification de l'ARN-VHC a été réalisée par PCR en temps réel. Les malades ont été traités par la combinaison interféron pégylé alfa-2a et ribavirine.Résultats : Au total, 46 patients ont été inclus dont 30 hommes (65,2 %). L'âge moyen était de 47 ans. L'hépatite C a été découverte à l'occasion d'un bilan de santé (37 %), d'une cytolyse (34,8 %), d'un don de sang (15,2 %). Cinq patients (10,9 %) avaient des antécédents de transfusion sanguine. L'examen physique était normal chez 42 patients (91,3 %), quatre patients (8,7 %) avaient une cirrhose. La charge virale moyenne était de 960 978 UI/ml (5,9 log). Les géno-types 1, 2 et 5 ont été retrouvés avec une prédominance du type 2 (71,1 %). Dix-huit patients naïfs ont été traités. Tous génotypes confondus, la réponse virologique soutenue (RVS) a été de 81,2 % dont 92,3 % pour le génotype 2. Trois cas de rechute et deux arrêts de traitement à cause d'effets secondaires sévères ont été observés. La baisse du taux d'hémoglobine a été en moyenne de 3 ± 1,7 g/dl. Une neutropénie inférieure à 750/mm 3 a été observée chez six patients (33,3 %). Deux patients ont présenté une thrombopénie inférieure ou égale à 100 000/mm 3 (11,1 %). La dose d'interféron pégylé a été réduite chez huit patients (44,4 %), celle de la ribavirine chez quatre (22,2 %). Une dépression a été diagnostiquée chez trois patients (6,5 %). Pour citer cette revue : J. Afr. Hépatol. Gastroentérol. 5 (2011).Mots clés Hépatite C chronique · Épidémiologie · Diagnostic · Traitement · Burkina Faso · Afrique de l'OuestAbstract The aim of this study was to describe epidemiological, diagnosis and therapeutic aspects of chronic hepatitis C. Patients and methods: It is a clinical prospective study carried out from October 2005 to November 2009 in the Hepatogastroenterology Department of Yalgado-Ouédraogo Teaching Hospital in Ouagadougou. We included patients with HCV antibodies and HCV-RNA positive. The quantification of HCV-RNA was done in real-time PCR. Treatment regimen was a combined therapy using peginterferon alfa-2a plus ribavirin. Results: A total of 46 patients were enrolled, among whom 30 were men (65.2%). The mean age was 47 years. Circumstances of finding out chronic hepatitis C were: medical check-up (37%), increased transaminases (34.8%) and blood donation (15.2%). Five patients (10.9%) had a history of blood transfusion. Physical examination was normal in 42 cases (91.3%), and we found out cirrhosis in 4 patients (8.7%). The mean viral load was 960,978 IU/ml (5.9 log). The genotypes of HCV were 1, 2 and 5, with a predominant genotype 2 (71.1%). Eighteen patients who had not previously been treated underwent combination therapy. R. Sombie (*) 09 BP ...

show abstract

Hépatite B chronique: aspects épidémiologique, diagnostique, thérapeutique et évolutif au centre hospitalier universitaire Yalgado Ouédraogo de Ouagadougou

Cited by 18 publications

References 26 publications

Hepatitis B Surface Antigen Should Not Be the Only Sought Marker to Distinguish Blood Donors towards Hepatitis B Virus Infection in High Prevalence Area

Hepatitis B Surface Antigen Should Not Be the Only Sought Marker to Distinguish Blood Donors towards Hepatitis B Virus Infection in High Prevalence Area

Prevention of Mother-to-Child Transmission of Hepatitis B in the Urban District Health Baskuy Burkina Faso

Hépatite C chronique: épidémiologie, diagnostic et traitement au CHU Yalgado-Ouédraogo de Ouagadougou

Contact Info

Product

Resources

About