Hepatic volume changes after lobar selective internal radiation therapy (SIRT) of hepatocellular carcinoma

Theysohn, Jens; Ertle, Judith; Müller, Stefan; Schlaak, Joerg F.; Nensa, Felix; S, Sipilae; Bockisch, Andreas; Lauenstein, Thomas C.

doi:10.1016/j.crad.2013.09.009

Cited by 74 publications

(61 citation statements)

References 23 publications

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“…Subsequently, several groups have also published similar results from their retrospective experience [15][16][17][18][19][20][21][22] . The main limitations of these retrospective studies are that the patient cohorts were vastly heterogenous in terms of pathology treated, underlying liver disease, dosage and delivery of Y90, number of treatment sessions and time to measurement of hypertrophy.…”

Section: Y90 Radioembolizationsupporting

confidence: 60%

Contra-lateral liver lobe hypertrophy after unilobar Y90 radioembolization: An alternative to portal vein embolization?

Teo

Goh

2015

WJG

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Liver resection (LR) with negative margins confers survival advantage in many patients with hepatic malignancies. However, an adequate future liver remnant (FLR) is imperative for safe LR. Presently, in patients with an inadequate FLR; the 2 most established clinical techniques performed to induce liver hypertrophy are portal vein embolization (PVE) and portal vein ligation. More recently, it has been observed that patients who undergo treatment via Y90 radioembolization experience hypertrophy of the contra-lateral untreated liver lobe. Based on these observations, several investigators have proposed the potential use of this modality as an alternative technique for increasing the FLR prior to liver resection. Y90 radioembolization induces hypertrophy at a slower rate than PVE but has the added advantage of concomitant local disease control and tumour downstaging. Core tip: Both portal vein embolization and Y90 radioembolization induce significant hypertrophy of the contralateral lobe. Y90 radioembolization induces hypertrophy at a slower rate than PVE but has the added advantage of concomitant local disease control and tumour down-staging.Teo JY, Goh BKP. Contralateral liver lobe hypertrophy after unilobar Y90 radioembolization: An alternative to portal vein embolization? World

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Section: Y90 Radioembolizationsupporting

confidence: 60%

Contra-lateral liver lobe hypertrophy after unilobar Y90 radioembolization: An alternative to portal vein embolization?

Teo

Goh

2015

WJG

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“…20 Nine studies, published between 2008 and 2014 were identified. [11][12][13][14][15][16][17][18][19] Three studies 11,12,15 were reported from the same centre with overlapping patient cohorts. Two studies 11,12 were excluded; and only the most recent (and largest) report 15 was included.…”

Section: Data Extractionmentioning

confidence: 99%

“…The study by Teo et al 16 was the first to report that HCC patients with hepatitis B experience a significantly greater degree of hypertrophy after SIRT (44.5%) compared to those with hepatitis C or alcoholic cirrhosis (7.7%). Although acknowledging the limitation of their small sample size, the authors postulated that the difference in hypertrophy was due to differences in underlying pathogenesis, with cirrhosis being a more important factor in patients with hepatitis C or alcoholic liver disease.…”

Section: Other Findingsmentioning

confidence: 99%

A systematic review of contralateral liver lobe hypertrophy after unilobar selective internal radiation therapy with Y90

Teo

Allen

et al. 2015

HPB

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“…These effective diameters were measured in mm and defined as "volume-equivalent and area-equivalent diameters." The volume-equivalent diameter (D vol ) was calculated by inverting the sphere volume for-mula: D vol = (6 × V/π) ⅓ , whereby V = volume measurement (mm 3 ) and D vol = diameter (mm). To convert bidimensional measurements into unidimensional measurements, the surface area of a sphere was assumed.…”

Section: Data Managementmentioning

confidence: 99%

Response Evaluation of Malignant Liver Lesions After TACE/SIRT: Comparison of Manual and Semi-Automatic Measurement of Different Response Criteria in Multislice CT

Höink

Schülke

Koch

et al. 2017

Fortschr Röntgenstr

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ZUSAMMENFASSUNGZiel Vergleich von Messgenauigkeit und Interobserver-Variabilität in der computertomografischen Beurteilung von hepatozellulären Karzinomen (HCC) und Lebermetastasen vor und nach transarteriellen selektiven Therapien. Material und MethodenRetrospektive Studie an 72 Patienten mit malignen Leberläsionen (42 Metastasen, 30 HCC) vor und nach Therapie mit SIRT (n = 42) oder TACE (n = 29).Etablierte (LAD, SAD, WHO) und Vitalitäts-assoziierte Größenparameter (mRECIST, mLAD, mSAD, EASL) wurden manuell und semiautomatisch von zwei Auswertern bestimmt. Die relative Interobserverdifferenz (RID) und der Intraclass Korrelationskoeffizient (ICC) wurden berechnet.Ergebnisse Die mediane RID der Vitalitäts-assoziierten Parameter war für die semiautomatischen niedriger als für die manuellen Messverfahren, im Einzelnen: für mLAD 3,4 % gegenüber 12,5 %; für mSAD 5,7 % gegenüber 12,7 %; für This document was downloaded for personal use only. Unauthorized distribution is strictly prohibited. ABSTR AC TPurpose To compare measurement precision and interobserver variability in the evaluation of hepatocellular carcinoma (HCC) and liver metastases in MSCT before and after transarterial local ablative therapies. Materials and MethodsRetrospective study of 72 patients with malignant liver lesions (42 metastases; 30 HCCs) before and after therapy (43 SIRT procedures; 29 TACE procedures). Established (LAD; SAD; WHO) and vitality-based parameters (mRECIST; mLAD; mSAD; EASL) were assessed manually and semi-automatically by two readers. The relative interobserver difference (RID) and intraclass correlation coefficient (ICC) were calculated.Results The median RID for vitality-based parameters was lower from semi-automatic than from manual measurement of mLAD (manual 12.5 %; semi-automatic 3.4 %), mSAD (manual 12.7 %; semi-automatic 5.7 %) and EASL (manual 10.4 %; semi-automatic 1.8 %). The difference in established parameters was not statistically noticeable (p > 0.05). The ICCs of LAD (manual 0.984; semi-automatic 0.982), SAD (manual 0.975; semi-automatic 0.958) and WHO (manual 0.984; semi-automatic 0.978) are high, both in manual and semi-automatic measurements. The ICCs of manual measurements of mLAD (0.897), mSAD (0.844) and EASL (0.875) are lower. This decrease cannot be found in semi-automatic measurements of mLAD (0.997), mSAD (0.992) and EASL (0.998).Conclusion Vitality-based tumor measurements of HCC and metastases after transarterial local therapies should be performed semi-automatically due to greater measurement precision, thus increasing the reproducibility and in turn the reliability of therapeutic decisions.

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Hepatic volume changes after lobar selective internal radiation therapy (SIRT) of hepatocellular carcinoma

Cited by 74 publications

References 23 publications

Contra-lateral liver lobe hypertrophy after unilobar Y90 radioembolization: An alternative to portal vein embolization?

Contra-lateral liver lobe hypertrophy after unilobar Y90 radioembolization: An alternative to portal vein embolization?

A systematic review of contralateral liver lobe hypertrophy after unilobar selective internal radiation therapy with Y90

Response Evaluation of Malignant Liver Lesions After TACE/SIRT: Comparison of Manual and Semi-Automatic Measurement of Different Response Criteria in Multislice CT

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