Hepatic veno-occlusive disease: report of a case

Magnabosco, Elisiane Marcolin; Rivera, Michelle; Prolla, Ivo Roberto Dorneles; Verney, Yvelise; Mello, Evandro S.

doi:10.2223/jped.518

Cited by 7 publications

(5 citation statements)

References 6 publications

(10 reference statements)

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“…VOD was reported in a newborn infant whose mother drank herbal tea that contained detectable levels of the seconine PA during pregnancy (Roulet et al, 1988), as well as a preterm infant that developed VOD whose mother used an herbal mixture for cooking (Rasenack et al, 2003). In Brazil, leaves and inflorescences of S. brasiliensis are used in folk medicine to treat stomach pain (Toma et al, 2004) and has been reported to cause poisoning in children who consumed tea leaves of S. brasiliensis (Magnabosco et al, 1997).…”

Section: Introductionmentioning

confidence: 99%

Prenatal exposure to integerrimine N‐oxide impaired the maternal care and the physical and behavioral development of offspring rats

Sandini

Udo

Reis-Silva

et al. 2014

Intl J of Devlp Neuroscience

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Plants that contain pyrrolizidine alkaloids (PAs) have been reported as contaminants of pastures and food, as well as being used in herbal medicine. PAs are responsible for poisoning events in livestock and human beings. The aim of this present study was to evaluate effects of prenatal exposure to integerrimine N-oxide, the main PA found in the butanolic residue (BR) of Senecio brasiliensis, on both physical and behavioral parameters of Wistar rat offspring. The toxicity and maternal behavior were also evaluated. For this, pregnant Wistar rats received integerrimine N-oxide from the BR of Senecio brasiliensis, by gavage, on gestational days 6-20 (during organogenesis and fetal development period) at doses of 3, 6 and 9 mg/kg. During treatment, maternal body weight gain, and food and water intake were evaluated. After parturition, maternal behavior and aggressive maternal behavior were analyzed. In addition, physical development and behavioral assessments were observed in both male and female pups. Results showed that prenatal exposure to integerrimine N-oxide of S. brasiliensis induced maternal toxicity, impairment in maternal behavior and aggressive maternal behavior, mainly in the highest dose group. Between sexes comparison of pups showed loss of body weight, delayed physical development such as pinna detachment, hair growth, eruption of incisor teeth, eye and vaginal openings. These pups also showed a delay of palmar grasp, surface righting reflex, negative geotaxis and auditory startle reflexes. Thus, prenatal exposure to integerrimine N-oxide induces maternal toxicity, impairment of maternal care and delayed in physical and behavioral development of the offspring.

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Section: Introductionmentioning

confidence: 99%

Prenatal exposure to integerrimine N‐oxide impaired the maternal care and the physical and behavioral development of offspring rats

Sandini

Udo

Reis-Silva

et al. 2014

Intl J of Devlp Neuroscience

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“…No Brasil, S. brasiliensis é utilizada popularmente para diversas finalidades tais como: ferimentos da pele, vermífugo, dores estomacais e contra gripe (MAGNABOSCO et al, 1997;VISBISKI et al, 2003, TOMA, et al, 2004. No entanto, o uso indiscriminado desta planta pode causar danos à saúde humana, uma vez que foi relatado no nosso país casos de intoxicação em crianças e adultos que ingeriram chá de folhas de S. brasiliensis (MAGNABOSCO et al, 1997;TANIGUCHI et al, 2002).…”

Section: Sobre a Toxicidade Em Seres Humanosunclassified

Senecio brasiliensis e alcaloides pirrolizidínicos: toxicidade em animais e na saúde humana

2013

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ResumoNo Brasil, as plantas tóxicas são responsáveis por grande parte dos prejuízos econômicos em animais de produção, principalmente em equinos e bovinos. Nesse contexto, no Rio Grande do Sul, o gênero Senecio, especialmente S. brasiliensis Lessing, merece maior destaque por ser a principal causa de mortes de bovinos adultos. A toxicidade causada por esse gênero vegetal ocorre devido à presença dos alcaloides pirrolizidínicos, os quais sofrem biotransformação no fígado, gerando metabólitos tóxicos: os pirrois. Esses compostos tóxicos podem também ser nocivos para o homem através do consumo de produtos comestíveis, de origem animal, contaminados ou pelo uso dessa planta na medicina popular. Assim, o presente artigo traz uma revisão, em particular de S. brasiliensis com ênfase nos seus princípios ativos tóxicos e no mecanismo pelo qual se desenvolve a patogenia, além de abordar outras plantas que contêm os mesmos princípios tóxicos e que causam efeitos nocivos à saúde humana. Palavras-chave: Alcaloides pirrolizidínicos; Animais de produção; Humanos; Senecio brasiliensis; Toxicidade AbstractSenecio brasiliensis and pyrrolizidine alkaloids: toxicity to animals and human health. Most economic losses in Brazilian livestock production, especially in horses and cattle, are due to poison plants, such as those of the genus Senecio. Senecio brasiliensis Lessing is the main cause of death in cattle in the state of Rio Grande do Sul. The toxicity of this genus is attributed to their content of pyrrolizidine alkaloids, which undergo liver biotransformation creating toxic metabolites, namely pyrroles. These compounds can be transferred to humans through contaminated animal products or by the use of this plant in folk medicine. Thus, the present article is a review of the species S. brasiliensis, its toxic active principles and the mechanism by which pathogenesis occurs. Other plants with the same toxic principles that are harmful to human health are covered as well.

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“…Hepatic veno-occlusive disease (HVOD) [also known as hepatic sinusoidial obstruction syndrome (HSOS)] occurs sporadically throughout the world (1)(2)(3)(4)(5)(6)(7). Several factors cause HVOD: the intentional or unintentional intake of pyrrolizidine alkaloid (PA)-containing products (8,9).…”

Section: Introductionmentioning

confidence: 99%