Hepatic regeneration and functional recovery following partial liver resection in an experimental model of hepatic steatosis treated with omega-3 fatty acids

Marsman, Hendrik A.; Graaf, Wilmar de; Heger, Michal; Golen, Rowan F. van; Kate, Fiebo J.W. ten; Bennink, Roel J.; Gulik, Thomas M. van

doi:10.1002/bjs.9059

Cited by 46 publications

(49 citation statements)

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“…One study investigating this issue on a regenerating liver found a reduction in ROS production and an improvement in the antioxidant system [6]. Another study dealing with Ω3FAs supplementation, which did not use a regeneration model, reported that this compound did protect against oxidative stress induced DNA-damage in the liver [7]. However, there are contradicting studies reporting negative effects of long chain Ω3FAs on regenerating [26] and normal liver [27] with diverse results on oxidative stress.…”

Section: Discussionmentioning

confidence: 99%

“…Omega-3 fatty acids (Ω3FAs) and their longer chain downstream products such as eicosapentaenoic acid (EPA), docosapentaenoic acid (DPA) and docosahexaenoic acid (DHA) have been demonstrated as beneficial on the liver in several different aspects [456]. However, the number of studies focusing on the effects of Ω3FAs on liver regeneration is relatively few with different results [78]. Moreover, the effects of adding these emulsions to total parenteral nutrition (TPN) on the oxidative stress, which develop in the regenerating liver, are not clear.…”

Section: Introductionmentioning

confidence: 99%

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Omega-3 fatty acids inhibit oxidative stress in a rat model of liver regeneration

et al. 2017

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PurposeLipid peroxidation and consequent reactive oxygen species in the setting of oxidative stress have crucial roles in liver regeneration, which may adversely affect the regeneration itself and lead to liver failure. The aim of the current study is to investigate whether omega-3 fatty acid supplementation inhibits oxidative stress in an experimental model of liver regeneration.MethodsForty rats were allocated to four groups. Rats in group A received a sham operation. Rats in group B were subjected to right portal vein ligation (RPVL) and saline infusion. Rats in groups C and D were subjected to RPVL and total parenteral nutrition (TPN) with an all-in-one admixture containing a soybean oil based lipid emulsion. Rats in group D were additionally supplemented with omega-3 fatty acid infusion. Oxidative stresses in the blood and liver were measured by glutathione, superoxide dismutase, catalase, glutathione peroxidase, malondialdehyde, and nitric oxide.ResultsOmega-3 supplementation to the TPN solution significantly corrected alterations in the blood and tissue concentrations of oxidants and anti-oxidants during regeneration (P < 0.05).ConclusionOmega-3 fatty acid supplementation to the TPN solution revealed promising results in removal of oxidative stress that emerges during liver regeneration.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Omega-3 fatty acids inhibit oxidative stress in a rat model of liver regeneration

et al. 2017

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“…Marine-derived food sources such as fatty fish, seaweed, shellfish, microalgae and krill are rich in u-3 [13,14]. u-3 supplements are reported to be used in hepatic injury and steatosis [15]. EPA and DHA protected against arachidonic acid produced pro-inflammatory molecules through conversion to less inflammatory mediators, so EPA and DHA have antiinflammatory effects [16].…”

Section: Introductionmentioning

confidence: 99%

Hepatoprotective effects of glycyrrhizin and omega-3 fatty acids on Nuclear Factor-kappa B pathway in thioacetamide-induced fibrosis in rats

El-Magd

El-Karef

El‐Shishtawy

et al. 2015

Egyptian Journal of Basic and Applied Sciences

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Available online xxx Keywords:Liver fibrosis Glycyrrhizin Omega-3 fatty acids NF-kB MDA a b s t r a c t Nuclear Factor kappa B (NF-kB) is a key transcriptional regulator that plays important roles in the pathogenesis of hepatic inflammation and fibrosis in chronic liver diseases.NF-kB activation leads to production of pro-inflammatory and fibrogenic cytokines.Glycyrrhizin (GL) is reported to suppress liver fibrosis and cirrhosis. Omega-3 fatty acids (u-3) play an anti-inflammatory role and they are reported to decrease hepatic injury in Thioacetamide (TAA) fibrotic model. We investigated the effects of GL and u-3 on liver inflammation and fibrosis in rats and clarified the effects of these natural compounds on NF-kB level. 50 male Wistar rats randomized to 5 groups: Control group and 4 groups received TAA 200 mg/kg i.p. twice weekly for 8 weeks: TAA group, GL group (received GL 25 mg/kg daily by oral tube), u-3 group (received u-3150 mg/kg daily by oral tube), (GL þ u-3) group (received similar combined doses of both natural compounds). GL and u-3 alone or in combination protected the liver from TAA hepatotoxic effects as they significantly decreased serum AST activity and serum total bilirubin level, they also significantly increased serum albumin and total protein levels. The hepatoprotective effects of GL and u-3 were confirmed by the histopathological analysis as they significantly reduced the necroinflammatory scores and the extent of fibrosis. GL and u-3 significantly decreased liver malondialdehyde level (P < 0.005), liver NF-ƙB level (P < 0.005) and its tissue expression as detected by immunohistochemistry. In conclusion, glycyrrhizin and omega-3 fatty acids alone or in combination have potent antiinflammatory, anti-oxidant and anti-fibrotic effects.Please cite this article in press as: Abo El-Magd NF, et al., Hepatoprotective effects of glycyrrhizin and omega-3 fatty acids on Nuclear Factor-kappa B pathway in thioacetamide-induced fibrosis in rats, Egyptian Journal of Basic and Applied Sciences (2015), http://dx.

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“…13 In addition, V3FA seem to improve recovery of lean liver from resection-induced liver failure, or of fatty liver after standard resection. 14,15 Whether such effects are indirect (eg, by protecting from injury) or direct (eg, by promoting hepatocyte proliferation) remains unclear, but the resulting benefits can also be observed in the clinic. 16 Finally, V3FA have been associated with anti-cancerous properties in a variety of neoplasms.…”

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confidence: 99%

Omega-3 Fatty Acids Protect Fatty and Lean Mouse Livers After Major Hepatectomy

et al. 2017

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Objective: The aim of this study was to assess the effect of V3 fatty acids (V3FA) on fatty and lean liver in hepatic surgery. Background: The global spread of energy-dense diets has led to an endemic rise in fatty liver disease and obesity. Besides metabolic pathologies, steatosis enhances hepatic sensitivity to ischemia reperfusion (I/R) and impedes liver regeneration (LR). Steatosis limits the application of liver surgery, still the main curative option for liver cancer. V3FA are known to reverse steatosis, but how these lipids affect key factors defining surgical outcomes-that is, I/R, LR, and liver malignancy-is less clear. Methods: We established a standardized mouse model of high fat diet (HFD)-induced steatosis followed by V3FA treatment and the subsequent assessment of V3FA effects on I/R, LR, and liver malignancy (n ¼ 5/group), the latter through a syngeneic metastasis approach. Fatty liver outcomes were compared with lean liver to assess steatosis-independent effects. Nonparametric statistics were applied. Results: V3FA reversed HFD-induced steatosis and markedly protected against I/R, improved LR, and prolonged survival of tumor-laden mice. Remarkably, these beneficial effects were also observed in lean liver, albeit at a smaller scale. Notably, mice with metastases in fatty versus lean livers were associated with improved survival. Conclusions: V3FA revealed multiple beneficial effects in fatty and lean livers in mice. The improvements in I/R injury, regenerative capacity, and oncological outcomes await confirmatory studies in humans.

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Hepatic regeneration and functional recovery following partial liver resection in an experimental model of hepatic steatosis treated with omega-3 fatty acids

Abstract: Omega-3 FAs effectively reduced severe hepatic steatosis, which was associated with improved liver regeneration and functional recovery following partial hepatectomy.

Cited by 46 publications

References 28 publications

Omega-3 fatty acids inhibit oxidative stress in a rat model of liver regeneration

Omega-3 fatty acids inhibit oxidative stress in a rat model of liver regeneration

Hepatoprotective effects of glycyrrhizin and omega-3 fatty acids on Nuclear Factor-kappa B pathway in thioacetamide-induced fibrosis in rats

Omega-3 Fatty Acids Protect Fatty and Lean Mouse Livers After Major Hepatectomy

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