Hepatic protective effect of grape seed proanthocyanidin extract against Gleevec-induced apoptosis, liver Injury and Ki67 alterations in rats

Abstract

Gleevec (imatinib) is an antineoplastic chemotherapeutic agent used in the treatment of many types of cancer. The current study was conducted to examine the possible modifying effects of grape seeds proanthocyandins extract (GSPE) against apoptosis, liver injury and Ki67 alterations induced by Gleevec in male rats. 40 male albino rats were equally divided into four groups (First and second groups were control and GSPE groups; third group was Gleevec group and fourth group was treated with Gleevec and GSPE). Gleevec induced elevations in P53 and depletion of Bcl2 levels in liver tissues were compared with the control group. Liver sections in rats treated with Gleevec exhibited marked cellular infiltrations, vacuolar degeneration hepatocytes, numerous apoptotic cells, and congestion in central and portal veins, as well as a significant increase in the proliferating of Ki67 after Gleevec injection as compared with control group. In contrast, treatment with Gleevec and GSPE showed a moderate to good degree of improvement in hepatocytes with a significant increase in Ki67, a decrease in P53 and an increase in Bcl2 levels in liver tissues compared to treatment with Gleevec. Therefore, Gleevec induces apoptosis, injury and Ki67 changes in rat liver, whereas GSPE modulates these alternations.

Evaluation of the Cardiac Protection Conferred by Proanthocyanidins in Grape Seeds against Development of Ehrlich Solid Tumors in Mice

“…Many types of vegetables, seeds, and fruit contain the natural antioxidant proanthocyanidins, which comprises various phenolic compounds [12,13]. Red grape seeds have been found to contain a number of polyphenolic antioxidants, with a proportion of proanthocyanidins of around 89%, including 6.6% dimers, 5% trimers, 2.9% tetramers, and 74.8% oligomers [14,15]. e red grape seed extract known as grape seed proanthocyanidins extract (GSPE) presents various biological qualities, being effective against inflammation, apoptosis, proliferation, oxidants, and oxidative stress [14].…”

“…Red grape seeds have been found to contain a number of polyphenolic antioxidants, with a proportion of proanthocyanidins of around 89%, including 6.6% dimers, 5% trimers, 2.9% tetramers, and 74.8% oligomers [14,15]. e red grape seed extract known as grape seed proanthocyanidins extract (GSPE) presents various biological qualities, being effective against inflammation, apoptosis, proliferation, oxidants, and oxidative stress [14]. e purpose of this study was to investigate whether GSPE protected against the cardiac toxicity and oxidative stress caused by the Ehrlich solid tumor (EST).…”

Modulatory effects of Saussurea lappa root aqueous extract against ethephon‐induced kidney toxicity in male rats

“…Phytochemicals derived from herbal plants have been proved to be valuable for treatment of several ailments . Costus or Saussurea lappa is among the most widely used medicinal plants in several traditional systems of medicine for treatment of several diseases including rheumatism, cold, cough, headache, stomach ache, and throat infection .…”

“…13 Phytochemicals derived from herbal plants have been proved to be valuable for treatment of several ailments. [14][15][16][17][18] Costus or Saussurea lappa is among the most widely used medicinal plants in several traditional systems of medicine for treatment of several diseases including rheumatism, cold, cough, headache, stomach ache, and throat infection. 19 Saussurea lappa has been screened for different pharmacological activities such as antioxidant, 20 antihepatotoxic, 21 anticancerous, 22 anti-inflammatory, 23 antiulcerous, 24 antimicrobial, 25 immunomodulatory, 26 cardioprotective, 27 antiepileptic, 28 and antihyperlipidemic activities.…”

Biochemical and Molecular Studies on the Role of Rosemary (Rosmarinus officinalis) Extract in Reducing Liver and Kidney Toxicity Due to Etoposide in Male Rats

“…Today, there are many different kinds of chemotherapy that used for cancer treatments. It is therefore important to search for therapies which can reduce the side effects of anticancer treatments without altering their efficacy or increasing toxicity or damage in target organs [1][2][3][4][5][6][7][8]. Vepesid is the trade name for etoposide.…”