Hepatic Protection by Noni Fruit Juice Against CCl4-Induced Chronic Liver Damage in Female SD Rats

Abstract

Morinda citrifolia L. (noni) has been used throughout the Pacific, Southeast Asia, Central America, and the Caribbean for a variety of health conditions, including heart and liver ailments. In this study, we examined the hepatoprotective effects of TAHITIAN NONI Juice (TNJ) against CCl(4)-induced chronic liver damage in female Sprague Dawley (SD) rats. Twelve female SD rats were divided into control, placebo and TNJ (6 mL/rat/day) groups. On day 15, animals in the placebo and TNJ groups received 0.25 mL/kg CCl(4) in corn oil once a week for 12 successive weeks. All animals were sacrificed at week 16. Blood and liver were collected for liver function, lipid panel tests, and histological observation. Histopathological examination revealed that liver sections from the TNJ + CCl(4) appeared similar to controls, whereas typical hepatic steatosis was observed in the placebo + CCl(4) group. Serum alkaline phosphatase (ALP), aspartate aminotransferase (AST), alanine transaminase (ALT), total cholesterol (TC), triglycerides (TG), low-density lipoprotein (LDL), and very low-density lipoprotein (VLDL) levels were increased in the placebo group compared with the TNJ group. In contrast, high-density lipoprotein (HDL) was increased in the TNJ group and decreased in the placebo group. Thus, TNJ juice appears to protect the liver from chronic exogenous CCl(4) exposures. Such protective mechanisms are supportive evidence for the utility of noni in traditional medicine for liver ailments.

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“…4c) levels were elevated in EAC control cluster which indicates that EAC cells induce hepatotoxicity. Reduction in the above biochemical markers levels by dint of NJ and DNG respectively in CP challenged mice indicates that NJ and DNG correspondingly possesses the protective effect against EAC cell induced hepatotoxicity this result is correlated with Wang et al, 37 who were demonstrated that hepatoprotective activity of fermented NJ against CCl 4 induced liver injury. Exhibited above myeloprotective and hepatoprotective properties of NJ and DNG may be due to the antioxidant activity of their phenolic and flavonoids compounds.…”

Hepatoprotective Effects of Arbutin against Liver Damage Induced by Carbon Tetrachloride in Rats

“…Previous studies have demonstrated the antioxidant activities of arbutin (41). Lipid peroxidation has been involved in the pathogenesis of hepatic injury by free radical derivatives of CCl 4 and is responsible for cell membrane damage and the subsequent release of marker enzymes of hepatotoxicity (22,40,42). In the present study, significantly elevated levels of TBARS, the product of membrane lipid peroxidation observed in CCl 4 -administered rats, indicated hepatic damage.…”

“…Pretreatment with arbutin significantly improved the structure of hepatic cells. These results suggest that arbutin is effective at reversing the hepatotoxicity caused by CCl 4 . Morphometric studies have confirmed these observations.…”

“…The liver regulates hemostasis (3) and appears to have the physiological function of protecting the body from harmful drugs and chemicals (3). Considering the high prevalence of liver disease globally (2), the pathogenesis of this disease is an important public health problem (4). Despite significant scientific advancements in the field of hepatology in recent years, the incidence of liver disease is still increasing (3).…”

Male Rat Susceptibility for Liver and Kidney Injury

“…Therefore, in most experimental animal models especially inducing liver injury, the LFT is the well-known parameter to measure activity of liver enzyme (Wang, et al, 2008).…”