Hepatic multiple myelolipoma with severe coelomic edema in a red-bellied tamarin (Saguinus labiatus)

Abstract

This report describes hepatic multiple myelolipoma with severe coelomic edema in a 14-year-old, male red-bellied tamarin (Saguinus labiatus). Multiple small and large nodules were formed in all lobes of the liver. Histopathologically, the nodules comprised mature and normal adipocytes and hematopoietic elements at various ratios that were composed of granulocytic, erythrocytic, and megakaryocytic series in various phases of maturation. All nodules were encapsulated and demarcated hepatocytes around masses. Myelolipoma in the liver is rare, and there are no reports of any cases to date. To our knowledge, this is the first report of hepatic multiple myelolipoma in a red-bellied tamarin.

Hepatic myelolipoma in two Goeldi's monkeys from South America held captive

“…The monkeys in the present report lived together in the same environment for 13 years. In the rare cases that hepatic and/or adrenal myelolipomas were described in another primate species, such as common marmoset, red‐bellied tamarin, cotton‐top tamarin, and chimpanzee, little was explained about the risk factors for the disease.…”

Spontaneous retroperitoneal liposarcoma in a free‐ranging juvenile golden‐headed lion tamarin (Leontopithecus chrysomelas)

“…. Hepatic myelolipomas are frequent in common marmoset ( Callithrix jacchus ), chimpanzee, red‐bellied tamarin ( Saguinus labiatus ), and Goeldi's monkeys ( Callimico goeldii ) . Conversely, there are only few reported liposarcoma cases.…”

“…Lipomas are common in the subcutis and mesentery of captive middle-aged and geriatric chimpanzees (Pan troglodytes) and baboons (Papio spp.). 2,3 Hepatic myelolipomas are frequent in common marmoset (Callithrix jacchus), 4 chimpanzee, 5 red-bellied tamarin (Saguinus labiatus), 6…”

Hepatocellular carcinoma in a free‐living marmoset (Callithrix sp.) with concomitant biliary trematodiasis

“…Other PLNs reported in NHPs are hepatoma in sooty mangabey ( Cercocebus atys ); neuroendocrine carcinoma in baboon ( Papio sp. ); and myelolipoma in common marmoset ( Callithrix jacchus ), chimpanzee, red‐bellied tamarin ( Saguinus labiatus ), and Goeldi's monkeys ( Callimico goeldii ) …”

“…19 Other PLNs reported in NHPs are hepatoma in sooty mangabey (Cercocebus atys); 20 neuroendocrine carcinoma in baboon (Papio sp. ); 21 and myelolipoma in common marmoset (Callithrix jacchus), 22 chimpanzee, 9 red-bellied tamarin (Saguinus labiatus), 23 and Goeldi's monkeys (Callimico goeldii). [24][25][26][27] In humans, risk factors for HCC include hepatitis B (HBV) and C (HCV) virus infections; chemical carcinogens (eg, nitrosamines, aflatoxin B1 [AFB1]); 28 and causes of cirrhosis, for example, alcoholic and non-alcoholic steatohepatitis.…”