Hepatic metabolism of contaminants in the terapontid fish, yellowtail trumpeter (Amniataba caudavittata Richardson)

Webb, Diane; Gagnon, Marthe Monique; Rose, Tom

doi:10.1002/tox.20307

Cited by 11 publications

(5 citation statements)

References 30 publications

(40 reference statements)

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“…After incubation, we added 10 µL of NADPH (3 mM). We used a wavelength of 530 nm (excitation) and 590 nm (emission) for 10 min at 27 ° C in the analysis (Webb et al, 2008).…”

Section: Biochemical Biomarkersmentioning

confidence: 99%

Liver damage in two neotropical fish species from a polluted estuarine area

Santos¹,

Piancini²,

Osório³

et al. 2024

Ecotoxicol. Environ. Contam.

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A multi-biomarker approach was used to evaluate the liver health of two Neotropical fish species (Cathorops spixii and Atherinella brasiliensis) that inhabit two different sites of the Paranaguá bay (Paraná-Brazil) and a reference site in the Garatuba bay. Fish were sampled during summer and winter, so the variation of the responses can reflect the actual conditions of sampling sites. Data showed that fish from both sites of the Paranaguá bay are affected by the presence of pollutants from different sources. Both fish species presented adverse biomarker responses mainly in the summer, probably due to the increased human population during the period. Chronic effects in the liver related with the contamination. Thus, the results demonstrated that pollution in Paranaguá bay induce liver damage in fish that inhabit this area.

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“…After incubation, we added 10 µL of NADPH (3 mM). We used a wavelength of 530 nm (excitation) and 590 nm (emission) for 10 min at 27 ° C in the analysis (Webb et al, 2008).…”

Section: Biochemical Biomarkersmentioning

confidence: 99%

Liver damage in two neotropical fish species from a polluted estuarine area

Santos¹,

Piancini²,

Osório³

et al. 2024

Ecotoxicol. Environ. Contam.

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“…The liver in fish is susceptible to xenobiotic‐induced injury for its critical role in xenobiotic metabolism, its portal location in the circulation of blood, and its anatomic and physiologic structures [3]. Numerous chemical compounds have showed the potential to liver injury [4, 5]. Presently, a fish liver injury called “liver and gall syndrome” in China, manifested by the color change and enlargement (up to twofold or more of original size) in liver, along with the characteristics of emaciation, poor growth performance and feeding efficiency, has caused a considerable loss to aquaculture in China [6].…”

Section: Introductionmentioning

confidence: 99%

Polysaccharide derived from pomelo seed coat ameliorates APAP‐induced liver injury in hybrid grouper (Epinephelus lanceolatus♂ × Epinephelus fuscoguttatus♀)

Fang

Huang

Zhang

et al. 2021

eFood

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Ever-increasingly Citrus wastes have been generating during the industrial processing, which is troublesome to dispose them for the considerations of economic feasibility and environmental protection. Meanwhile, liver disease, which causes liver damage, is the one of the major threats for the further development of aquaculture, especially in marine fish. The present study explored the hepatoprotective effect of PSCP, a polysaccharide extracted from the pomelo seed coat, in the primary hepatocytes of hybrid grouper (Epinephelus fuscoguttatus♂ × Epinephelus lanceolatus♀). PSCP displayed considerably scavenging effect to the free radicals and strong inhibitive effect to the erythrocyte hemolysis. In vitro, we added PSCP (0, 100, 200 and 400 μg/mL) to the primary hepatocytes before incubation with Acetaminophen (APAP) (12 mM). The CKK-8 experiment displayed the administration of PSCP (100 and 200 μg/mL) substantially mitigated the reduction of hepatocyte viability inflicted by APAP. Moreover, we found that PSCP effectively alleviated APAP-induced oxidative stress, as shown by the significantly reduced level of reactive oxygen species and the elevated enzymatic activities of superoxide dismutase, catalase, and glutathione peroxidase, which indicated its anti-liver injury effect (P<0.05). The more direct signs associating with the hepatoprotection of PSCP are reflected in the results of hematoxylin and eosin staining, as evident by the morphological recovery following the addition of PSCP. In brief, these findings showed that the therapeutic potential of PSCP on APAP-induced fish liver injury, which not only provided a now prospect in treating the liver impairment in aquatic animals, but to also improve the utilization of pomelo fruitlets.

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“…Many compounds, including chlorinated solvents, alcohol, drugs, peroxidized fatty acids, fungal toxins, and industrial pollutants, can cause liver damage through their metabolic conversion to highly reactive substances and the generation of free radicals (Myers et al, 1991;Webb et al, 2008). Presently in China, a fish liver disease called "fish hepatobiliary syndrome", with the symptoms of color change and enlargements of the liver and gall bladder, characterized by liver cell necrosis, has been frequently reported and caused dramatic losses in many cultured species due to the environmental pollution and heavy use of pesticides and chemotherapeutics (Meng and Ding, 2004).…”

Section: Introductionmentioning

confidence: 99%