Hepatic Granulomas and Other Hepatic Lesions Associated with BCG Immunotherapy for Cancer

Bodurtha, A.; Kim, Y. H.; Laucius, J. F.; Donato, Rocco; Mastrangelo, Michael J.

doi:10.1093/ajcp/61.6.747

Cited by 41 publications

(11 citation statements)

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“…We noted one case that was caused by systemic BCG infection after an intravesicular BCG injection for a bladder tumour, which has been described previously. [33][34][35][36] We may have expected some opportunistic infections (for example, Mycobacterium avium intracellulare, toxoplasmosis) to account for some cases in human immunodeficiency virus infected patients, but these patients are exclusively cared for in a dedicated infectious diseases unit at another hospital in our city.…”

Section: Discussionmentioning

confidence: 99%

Hepatic granulomas: a 10 year single centre experience

Gaya

Thorburn²,

Oien³

et al. 2003

Journal of Clinical Pathology

169

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Section: Discussionmentioning

confidence: 99%

Hepatic granulomas: a 10 year single centre experience

Gaya

Thorburn²,

Oien³

et al. 2003

Journal of Clinical Pathology

169

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“…One subcutaneous lesion was injected with BCG but did not regress. T h e intensity of (1) stated with certainty that the apparent acceleration was treatment-related.…”

Section: Clinical Studiesmentioning

confidence: 99%

Intralesional BCG in the treatment of metastatic malignant melanoma

Mastrangelo

Sulit

Prehn

et al. 1976

Cancer

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The therapeutic efficacy of intralesional BCG (Bacillus Calmette‐Guerin; one immunizing dose every 2 weeks for a minimum of five treatments) was studied in 19 melanoma patients. Of 15 patients evaluable for response, five experienced significant objective improvement (two complete and three partial remissions). Objective improvement was limited to those patients with dermal metastatic disease. In vitro cytotoxicity in the presence of patient's serum bore, on average, a relationship to the clinical disease. In certain individual cases, serum blocking and/or lymphocyte stimulation may have had prognostic significance.

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“…BCG-CWP therapy and radical surgical procedures did not indicate granulomatous changes in any organ which would have led to the conclusion of a dissemination effect such as has been described, for example, by Hunt et al [10] and Bodurtha et al [2] for the bone marrow, liver, and lungs.…”

Section: Discussionmentioning

confidence: 60%